Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients
Abstract In a recent report, Ascuntar et al. describes the impossibility to demonstrate a significant association between early antibiotic therapy administration and mortality in sepsis patients. Nevertheless, we believe that some methodological issues deserve their conclusions. First, the objective...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | Journal of Intensive Care |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40560-020-00471-2 |
| _version_ | 1818282667394727936 |
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| author | Romain Jouffroy Benoît Vivien |
| author_facet | Romain Jouffroy Benoît Vivien |
| author_sort | Romain Jouffroy |
| collection | DOAJ |
| description | Abstract In a recent report, Ascuntar et al. describes the impossibility to demonstrate a significant association between early antibiotic therapy administration and mortality in sepsis patients. Nevertheless, we believe that some methodological issues deserve their conclusions. First, the objective of the authors of an early antibiotic therapy may be ambitious considering practical daily emergency department limitation. Second, most of patients included in the study appear to suffer from sepsis and not from septic shock, which limits the impact of an early and aggressive management. At last, more than a single intervention such as antibiotic therapy, sepsis treatment is now considered as based on a “bundle of care.” |
| first_indexed | 2024-12-13T00:24:39Z |
| format | Article |
| id | doaj.art-40b0d857dbe540b591f32236aa10f896 |
| institution | Directory Open Access Journal |
| issn | 2052-0492 |
| language | English |
| last_indexed | 2024-12-13T00:24:39Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Intensive Care |
| spelling | doaj.art-40b0d857dbe540b591f32236aa10f8962022-12-22T00:05:28ZengBMCJournal of Intensive Care2052-04922020-07-01811210.1186/s40560-020-00471-2Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patientsRomain Jouffroy0Benoît Vivien1SAMU de Paris, Service d’Anesthésie Réanimation, Hôpital Universitaire Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris, AP-HP.Centre and Université de ParisSAMU de Paris, Service d’Anesthésie Réanimation, Hôpital Universitaire Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris, AP-HP.Centre and Université de ParisAbstract In a recent report, Ascuntar et al. describes the impossibility to demonstrate a significant association between early antibiotic therapy administration and mortality in sepsis patients. Nevertheless, we believe that some methodological issues deserve their conclusions. First, the objective of the authors of an early antibiotic therapy may be ambitious considering practical daily emergency department limitation. Second, most of patients included in the study appear to suffer from sepsis and not from septic shock, which limits the impact of an early and aggressive management. At last, more than a single intervention such as antibiotic therapy, sepsis treatment is now considered as based on a “bundle of care.”http://link.springer.com/article/10.1186/s40560-020-00471-2Antibiotic therapySepsisEarlyMortalityConfounderMethodological issue |
| spellingShingle | Romain Jouffroy Benoît Vivien Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients Journal of Intensive Care Antibiotic therapy Sepsis Early Mortality Confounder Methodological issue |
| title | Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients |
| title_full | Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients |
| title_fullStr | Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients |
| title_full_unstemmed | Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients |
| title_short | Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients |
| title_sort | antimicrobials administration time in patients with suspected sepsis faster is better for severe patients |
| topic | Antibiotic therapy Sepsis Early Mortality Confounder Methodological issue |
| url | http://link.springer.com/article/10.1186/s40560-020-00471-2 |
| work_keys_str_mv | AT romainjouffroy antimicrobialsadministrationtimeinpatientswithsuspectedsepsisfasterisbetterforseverepatients AT benoitvivien antimicrobialsadministrationtimeinpatientswithsuspectedsepsisfasterisbetterforseverepatients |