CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signaling.
Hedgehog (Hh) signaling plays essential roles in various developmental processes, and its aberrant regulation results in genetic disorders or malignancies in various tissues. Hyperactivation of Hh signaling is associated with lung cancer development, and there have been extensive efforts to investig...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4219762?pdf=render |
| _version_ | 1818484064516046848 |
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| author | Young-Eun Leem Hye-Lim Ha Ju-Hyeon Bae Kwan-Hyuck Baek Jong-Sun Kang |
| author_facet | Young-Eun Leem Hye-Lim Ha Ju-Hyeon Bae Kwan-Hyuck Baek Jong-Sun Kang |
| author_sort | Young-Eun Leem |
| collection | DOAJ |
| description | Hedgehog (Hh) signaling plays essential roles in various developmental processes, and its aberrant regulation results in genetic disorders or malignancies in various tissues. Hyperactivation of Hh signaling is associated with lung cancer development, and there have been extensive efforts to investigate how to control Hh signaling pathway and regulate cancer cell proliferation. In this study we investigated a role of CDO, an Hh co-receptor, in non-small cell lung cancer (NSCLC). Inhibition of Hh signaling by SANT-1 or siCDO in lung cancer cells reduced proliferation and tumorigenicity, along with the decrease in the expression of the Hh components. Histological analysis with NSCLC mouse tissue demonstrated that CDO was expressed in advanced grade of the cancer, and precisely co-localized with GLI1. These data suggest that CDO is required for proliferation and survival of lung cancer cells via Hh signaling. |
| first_indexed | 2024-12-10T15:50:26Z |
| format | Article |
| id | doaj.art-40b291674c3a48b5a5340662480466a7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T15:50:26Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-40b291674c3a48b5a5340662480466a72022-12-22T01:42:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11170110.1371/journal.pone.0111701CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signaling.Young-Eun LeemHye-Lim HaJu-Hyeon BaeKwan-Hyuck BaekJong-Sun KangHedgehog (Hh) signaling plays essential roles in various developmental processes, and its aberrant regulation results in genetic disorders or malignancies in various tissues. Hyperactivation of Hh signaling is associated with lung cancer development, and there have been extensive efforts to investigate how to control Hh signaling pathway and regulate cancer cell proliferation. In this study we investigated a role of CDO, an Hh co-receptor, in non-small cell lung cancer (NSCLC). Inhibition of Hh signaling by SANT-1 or siCDO in lung cancer cells reduced proliferation and tumorigenicity, along with the decrease in the expression of the Hh components. Histological analysis with NSCLC mouse tissue demonstrated that CDO was expressed in advanced grade of the cancer, and precisely co-localized with GLI1. These data suggest that CDO is required for proliferation and survival of lung cancer cells via Hh signaling.http://europepmc.org/articles/PMC4219762?pdf=render |
| spellingShingle | Young-Eun Leem Hye-Lim Ha Ju-Hyeon Bae Kwan-Hyuck Baek Jong-Sun Kang CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signaling. PLoS ONE |
| title | CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signaling. |
| title_full | CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signaling. |
| title_fullStr | CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signaling. |
| title_full_unstemmed | CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signaling. |
| title_short | CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signaling. |
| title_sort | cdo an hh coreceptor mediates lung cancer cell proliferation and tumorigenicity through hedgehog signaling |
| url | http://europepmc.org/articles/PMC4219762?pdf=render |
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