Solid-State Dewetting of Thin Au Films for Surface Functionalization of Biomedical Implants
Biomaterial-centered infections of orthopedic implants remain a significant burden in the healthcare system due to sedentary lifestyles and an aging population. One approach to combat infections and improve implant osteointegration is functionalizing the implant surface with anti-infective and osteo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/16/24/7524 |
| _version_ | 1797380187449458688 |
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| author | Aliya Sharipova Ivan Zlotver Alejandro Sosnik Eugen Rabkin |
| author_facet | Aliya Sharipova Ivan Zlotver Alejandro Sosnik Eugen Rabkin |
| author_sort | Aliya Sharipova |
| collection | DOAJ |
| description | Biomaterial-centered infections of orthopedic implants remain a significant burden in the healthcare system due to sedentary lifestyles and an aging population. One approach to combat infections and improve implant osteointegration is functionalizing the implant surface with anti-infective and osteoinductive agents. In this framework, Au nanoparticles are produced on the surface of Ti-6Al-4V medical alloy by solid-state dewetting of 5 nm Au film and used as the substrate for the conjugation of a model antibiotic vancomycin via a mono-thiolated poly(ethylene glycol) linker. Produced Au nanoparticles on Ti-6Al-4V surface are equiaxed with a mean diameter 19.8 ± 7.2 nm, which is shown by high-resolution scanning electron microscopy and atomic force microscopy. The conjugation of the antibiotic vancomycin, 18.8 ± 1.3 nm-thick film, is confirmed by high resolution-scanning transmission electron microscopy and X-ray photoelectron spectroscopy. Overall, showing a link between the solid-state dewetting process and surface functionalization, we demonstrate a novel, simple, and versatile method for functionalization of implant surfaces. |
| first_indexed | 2024-03-08T20:34:40Z |
| format | Article |
| id | doaj.art-40b372837edb429da900f82a9ab96659 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-08T20:34:40Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-40b372837edb429da900f82a9ab966592023-12-22T14:22:31ZengMDPI AGMaterials1996-19442023-12-011624752410.3390/ma16247524Solid-State Dewetting of Thin Au Films for Surface Functionalization of Biomedical ImplantsAliya Sharipova0Ivan Zlotver1Alejandro Sosnik2Eugen Rabkin3Department of Materials Science and Engineering, Technion–Israel Institute of Technology, Haifa 3200003, IsraelDepartment of Materials Science and Engineering, Technion–Israel Institute of Technology, Haifa 3200003, IsraelDepartment of Materials Science and Engineering, Technion–Israel Institute of Technology, Haifa 3200003, IsraelDepartment of Materials Science and Engineering, Technion–Israel Institute of Technology, Haifa 3200003, IsraelBiomaterial-centered infections of orthopedic implants remain a significant burden in the healthcare system due to sedentary lifestyles and an aging population. One approach to combat infections and improve implant osteointegration is functionalizing the implant surface with anti-infective and osteoinductive agents. In this framework, Au nanoparticles are produced on the surface of Ti-6Al-4V medical alloy by solid-state dewetting of 5 nm Au film and used as the substrate for the conjugation of a model antibiotic vancomycin via a mono-thiolated poly(ethylene glycol) linker. Produced Au nanoparticles on Ti-6Al-4V surface are equiaxed with a mean diameter 19.8 ± 7.2 nm, which is shown by high-resolution scanning electron microscopy and atomic force microscopy. The conjugation of the antibiotic vancomycin, 18.8 ± 1.3 nm-thick film, is confirmed by high resolution-scanning transmission electron microscopy and X-ray photoelectron spectroscopy. Overall, showing a link between the solid-state dewetting process and surface functionalization, we demonstrate a novel, simple, and versatile method for functionalization of implant surfaces.https://www.mdpi.com/1996-1944/16/24/7524biomaterialstitanium alloysthin filmswettingsurface functionalization |
| spellingShingle | Aliya Sharipova Ivan Zlotver Alejandro Sosnik Eugen Rabkin Solid-State Dewetting of Thin Au Films for Surface Functionalization of Biomedical Implants Materials biomaterials titanium alloys thin films wetting surface functionalization |
| title | Solid-State Dewetting of Thin Au Films for Surface Functionalization of Biomedical Implants |
| title_full | Solid-State Dewetting of Thin Au Films for Surface Functionalization of Biomedical Implants |
| title_fullStr | Solid-State Dewetting of Thin Au Films for Surface Functionalization of Biomedical Implants |
| title_full_unstemmed | Solid-State Dewetting of Thin Au Films for Surface Functionalization of Biomedical Implants |
| title_short | Solid-State Dewetting of Thin Au Films for Surface Functionalization of Biomedical Implants |
| title_sort | solid state dewetting of thin au films for surface functionalization of biomedical implants |
| topic | biomaterials titanium alloys thin films wetting surface functionalization |
| url | https://www.mdpi.com/1996-1944/16/24/7524 |
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