Distribution difference of colostrum-derived B and T cells subsets in gilts and sows.
Piglets are highly vulnerable to infections, but colostrum provides them with some protection. The function of colostrum components is unknown, as is if the amount and subsets of leukocytes in colostrum differ between gilts and sows. This study serially characterized leukocyte populations in colostr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0249366 |
| _version_ | 1818361061292638208 |
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| author | Ricardo Forner Gabrielly Bombassaro Franciana Volpato Bellaver Shaiana Maciag Francisco Noé Fonseca Danielle Gava Leticia Lopes Mariana Groke Marques Ana Paula Bastos |
| author_facet | Ricardo Forner Gabrielly Bombassaro Franciana Volpato Bellaver Shaiana Maciag Francisco Noé Fonseca Danielle Gava Leticia Lopes Mariana Groke Marques Ana Paula Bastos |
| author_sort | Ricardo Forner |
| collection | DOAJ |
| description | Piglets are highly vulnerable to infections, but colostrum provides them with some protection. The function of colostrum components is unknown, as is if the amount and subsets of leukocytes in colostrum differ between gilts and sows. This study serially characterized leukocyte populations in colostrum for differential leukocyte counts. Differences in humoral and cellular composition of colostrum between 40 gilts and 40 sows (parities orders 3-4) from a commercial herd were examined. Flow cytometry is a useful tool to identify and quantify leukocyte subsets in sow colostrum. Overall, there were no (p ≥ 0.05) parity differences in total macrophages, granulocytes, and T and B cells. However, the sows' colostrum presented significantly higher (p ≤ 0.05) T lymphocyte subsets than gilts, such as central memory CD4+T cells, effector memory CD4+T cells, and central memory CD8+T cells. Among B-lymphocytes, percentages of SWC7+CD5+ cells were significantly higher in sow colostrum than in that of gilts. As expected, IgG concentrations were significantly higher in sows than in gilts. Colostrum from sows had significantly greater mitogenic activity than colostrum from gilts and this fact can be associated with the potential to accelerate the maturation of a newborn's gastrointestinal tract. Our findings suggest that parity order may be one among other factors influencing the cell population and, consequently, the immune adaptive response in piglets that induces neutralizing antibodies and cellular immune responses to antigens. |
| first_indexed | 2024-12-13T21:10:42Z |
| format | Article |
| id | doaj.art-40b546a2222f4439b2a6788d5350e027 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T21:10:42Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-40b546a2222f4439b2a6788d5350e0272022-12-21T23:31:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01165e024936610.1371/journal.pone.0249366Distribution difference of colostrum-derived B and T cells subsets in gilts and sows.Ricardo FornerGabrielly BombassaroFranciana Volpato BellaverShaiana MaciagFrancisco Noé FonsecaDanielle GavaLeticia LopesMariana Groke MarquesAna Paula BastosPiglets are highly vulnerable to infections, but colostrum provides them with some protection. The function of colostrum components is unknown, as is if the amount and subsets of leukocytes in colostrum differ between gilts and sows. This study serially characterized leukocyte populations in colostrum for differential leukocyte counts. Differences in humoral and cellular composition of colostrum between 40 gilts and 40 sows (parities orders 3-4) from a commercial herd were examined. Flow cytometry is a useful tool to identify and quantify leukocyte subsets in sow colostrum. Overall, there were no (p ≥ 0.05) parity differences in total macrophages, granulocytes, and T and B cells. However, the sows' colostrum presented significantly higher (p ≤ 0.05) T lymphocyte subsets than gilts, such as central memory CD4+T cells, effector memory CD4+T cells, and central memory CD8+T cells. Among B-lymphocytes, percentages of SWC7+CD5+ cells were significantly higher in sow colostrum than in that of gilts. As expected, IgG concentrations were significantly higher in sows than in gilts. Colostrum from sows had significantly greater mitogenic activity than colostrum from gilts and this fact can be associated with the potential to accelerate the maturation of a newborn's gastrointestinal tract. Our findings suggest that parity order may be one among other factors influencing the cell population and, consequently, the immune adaptive response in piglets that induces neutralizing antibodies and cellular immune responses to antigens.https://doi.org/10.1371/journal.pone.0249366 |
| spellingShingle | Ricardo Forner Gabrielly Bombassaro Franciana Volpato Bellaver Shaiana Maciag Francisco Noé Fonseca Danielle Gava Leticia Lopes Mariana Groke Marques Ana Paula Bastos Distribution difference of colostrum-derived B and T cells subsets in gilts and sows. PLoS ONE |
| title | Distribution difference of colostrum-derived B and T cells subsets in gilts and sows. |
| title_full | Distribution difference of colostrum-derived B and T cells subsets in gilts and sows. |
| title_fullStr | Distribution difference of colostrum-derived B and T cells subsets in gilts and sows. |
| title_full_unstemmed | Distribution difference of colostrum-derived B and T cells subsets in gilts and sows. |
| title_short | Distribution difference of colostrum-derived B and T cells subsets in gilts and sows. |
| title_sort | distribution difference of colostrum derived b and t cells subsets in gilts and sows |
| url | https://doi.org/10.1371/journal.pone.0249366 |
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