Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias

Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias

Abstract Disrupting the methylation of telomeric silencing 1-like (DOT1L)-mediated histone H3 lysine 79 has been implicated in MLL fusion-mediated leukemogenesis. Recently, DOT1L has become an attractive therapeutic target for MLL-rearranged leukemias. Rigorous studies have been performed, and much...

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Bibliographic Details
Main Authors: Yan Yi, Shenglei Ge
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Hematology & Oncology
Subjects:
DOT1L
MLL-rearranged leukemia
Epigenetics
Histone modifications
Drug discovery
Small molecule inhibitors
Online Access:https://doi.org/10.1186/s13045-022-01251-1

Internet

https://doi.org/10.1186/s13045-022-01251-1

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