AKTIVITAS DIURETIK KOMBINASI EKSTRAK BIJI PEPAYA (Carica papaya L) DAN BIJI SALAK (Salacca zalacca varietas zalacca (Gaert.)Voss) PADA TIKUS JANTAN GALUR WISTAR (Rattus norvegicus L)
Research on diuretic activity of seed extract combination of papaya (Carica papaya L) and snake fruit (Salacca zalacca (Gaert.) Voss) to male wistar strain rats (Rattus norvegicus L.) has been conducted. This study aimed to determine the diuretic effect of the seed extract combination and its effect...
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| Format: | Article |
| Language: | English |
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Universitas Tadulako
2015-10-01
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| Series: | Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) |
| Subjects: | |
| Online Access: | http://jurnal.untad.ac.id/jurnal/index.php/Galenika/article/view/6241 |
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| author | Nurihardiyanti Nurihardiyanti Yuliet Yuliet Ihwan Ihwan |
| author_facet | Nurihardiyanti Nurihardiyanti Yuliet Yuliet Ihwan Ihwan |
| author_sort | Nurihardiyanti Nurihardiyanti |
| collection | DOAJ |
| description | Research on diuretic activity of seed extract combination of papaya (Carica papaya L) and snake fruit (Salacca zalacca (Gaert.) Voss) to male wistar strain rats (Rattus norvegicus L.) has been conducted. This study aimed to determine the diuretic effect of the seed extract combination and its effective dose combination as diuretics. The extract was prepared by maceration method using ethanol 96%. Diuretic activity test was divided into 5 treatment groups. Each group consisted of 5 rats. Group 1 (negative control) was given suspension of Na-CMC 0.5%; Group 2 (positive control) was given furosemide 3.6 mg/kgBW; Group 3, 4, and 5 were given dose combination of snake fruit seed extract and papaya seed extract successively at “37.5 mg/kgBW + 7.5 mg/kgBW”; “70 mg/kgBW + 15mg/kgBW”; and “140 mg/kgBW + 30 mg/kgBW”. Each rat was then orally given warm distilled water (70°C) 10ml/100gBW as loading dose. The excreted urine volume was measured and recorded every 30 minutes for 6 hours which was continued to cumulative urine volume calculation. Furthermore, sample was taken from the cumulative urine to measure levels of sodium (Na), potassium (K), and the pH of the urine. Data were statistically analyzed using ANOVA (Analysis of Variance). The results showed that the effective extract dose combination was found in Group 5’s dose (140 mg/kgBW of snake fruit seed extract and 30 mg/kgBW papaya seed extract) with diuretic activity index of 1.48; urine pH of 7.52; sodium saluretic index of 1.62; and potassium saluretik index of 1.56 |
| first_indexed | 2024-12-12T03:07:23Z |
| format | Article |
| id | doaj.art-40bf2a4e89b64469bbccfcff25feea5e |
| institution | Directory Open Access Journal |
| issn | 2442-7284 2442-8744 |
| language | English |
| last_indexed | 2024-12-12T03:07:23Z |
| publishDate | 2015-10-01 |
| publisher | Universitas Tadulako |
| record_format | Article |
| series | Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) |
| spelling | doaj.art-40bf2a4e89b64469bbccfcff25feea5e2022-12-22T00:40:29ZengUniversitas TadulakoJurnal Farmasi Galenika (Galenika Journal of Pharmacy)2442-72842442-87442015-10-011210511210.22487/j24428744.2015.v1.i2.62414994AKTIVITAS DIURETIK KOMBINASI EKSTRAK BIJI PEPAYA (Carica papaya L) DAN BIJI SALAK (Salacca zalacca varietas zalacca (Gaert.)Voss) PADA TIKUS JANTAN GALUR WISTAR (Rattus norvegicus L)Nurihardiyanti Nurihardiyanti0Yuliet Yuliet1Ihwan Ihwan2Universitas TadulakoUniversitas TadulakoUniversitas TadulakoResearch on diuretic activity of seed extract combination of papaya (Carica papaya L) and snake fruit (Salacca zalacca (Gaert.) Voss) to male wistar strain rats (Rattus norvegicus L.) has been conducted. This study aimed to determine the diuretic effect of the seed extract combination and its effective dose combination as diuretics. The extract was prepared by maceration method using ethanol 96%. Diuretic activity test was divided into 5 treatment groups. Each group consisted of 5 rats. Group 1 (negative control) was given suspension of Na-CMC 0.5%; Group 2 (positive control) was given furosemide 3.6 mg/kgBW; Group 3, 4, and 5 were given dose combination of snake fruit seed extract and papaya seed extract successively at “37.5 mg/kgBW + 7.5 mg/kgBW”; “70 mg/kgBW + 15mg/kgBW”; and “140 mg/kgBW + 30 mg/kgBW”. Each rat was then orally given warm distilled water (70°C) 10ml/100gBW as loading dose. The excreted urine volume was measured and recorded every 30 minutes for 6 hours which was continued to cumulative urine volume calculation. Furthermore, sample was taken from the cumulative urine to measure levels of sodium (Na), potassium (K), and the pH of the urine. Data were statistically analyzed using ANOVA (Analysis of Variance). The results showed that the effective extract dose combination was found in Group 5’s dose (140 mg/kgBW of snake fruit seed extract and 30 mg/kgBW papaya seed extract) with diuretic activity index of 1.48; urine pH of 7.52; sodium saluretic index of 1.62; and potassium saluretik index of 1.56http://jurnal.untad.ac.id/jurnal/index.php/Galenika/article/view/6241Snake fruit seedPapaya seedDiureticsUrine pHSodiumPotassium |
| spellingShingle | Nurihardiyanti Nurihardiyanti Yuliet Yuliet Ihwan Ihwan AKTIVITAS DIURETIK KOMBINASI EKSTRAK BIJI PEPAYA (Carica papaya L) DAN BIJI SALAK (Salacca zalacca varietas zalacca (Gaert.)Voss) PADA TIKUS JANTAN GALUR WISTAR (Rattus norvegicus L) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Snake fruit seed Papaya seed Diuretics Urine pH Sodium Potassium |
| title | AKTIVITAS DIURETIK KOMBINASI EKSTRAK BIJI PEPAYA (Carica papaya L) DAN BIJI SALAK (Salacca zalacca varietas zalacca (Gaert.)Voss) PADA TIKUS JANTAN GALUR WISTAR (Rattus norvegicus L) |
| title_full | AKTIVITAS DIURETIK KOMBINASI EKSTRAK BIJI PEPAYA (Carica papaya L) DAN BIJI SALAK (Salacca zalacca varietas zalacca (Gaert.)Voss) PADA TIKUS JANTAN GALUR WISTAR (Rattus norvegicus L) |
| title_fullStr | AKTIVITAS DIURETIK KOMBINASI EKSTRAK BIJI PEPAYA (Carica papaya L) DAN BIJI SALAK (Salacca zalacca varietas zalacca (Gaert.)Voss) PADA TIKUS JANTAN GALUR WISTAR (Rattus norvegicus L) |
| title_full_unstemmed | AKTIVITAS DIURETIK KOMBINASI EKSTRAK BIJI PEPAYA (Carica papaya L) DAN BIJI SALAK (Salacca zalacca varietas zalacca (Gaert.)Voss) PADA TIKUS JANTAN GALUR WISTAR (Rattus norvegicus L) |
| title_short | AKTIVITAS DIURETIK KOMBINASI EKSTRAK BIJI PEPAYA (Carica papaya L) DAN BIJI SALAK (Salacca zalacca varietas zalacca (Gaert.)Voss) PADA TIKUS JANTAN GALUR WISTAR (Rattus norvegicus L) |
| title_sort | aktivitas diuretik kombinasi ekstrak biji pepaya carica papaya l dan biji salak salacca zalacca varietas zalacca gaert voss pada tikus jantan galur wistar rattus norvegicus l |
| topic | Snake fruit seed Papaya seed Diuretics Urine pH Sodium Potassium |
| url | http://jurnal.untad.ac.id/jurnal/index.php/Galenika/article/view/6241 |
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