Applications of Lgr5-Positive Cochlear Progenitors (LCPs) to the Study of Hair Cell Differentiation

Applications of Lgr5-Positive Cochlear Progenitors (LCPs) to the Study of Hair Cell Differentiation

The mouse cochlea contains approximately 15,000 hair cells. Its dimensions and location, and the small number of hair cells, make mechanistic, developmental and cellular replacement studies difficult. We recently published a protocol to expand and differentiate murine neonatal cochlear progenitor ce...

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Bibliographic Details
Main Authors: Danielle R. Lenz, Niliksha Gunewardene, Dunia E. Abdul-Aziz, Quan Wang, Tyler M. Gibson, Albert S. B. Edge
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Lgr5
differentiation
proliferation
hair cells
supporting cells
cochlea
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00014/full

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