Genetic Susceptibility and Viral Clearance of Hepatitis C Virus infection
The hepatitis C virus (HCV) is still one of the leading causes of chronic hepatitis in the western world. Between 15% to 40% of the people acutely infected achieve spontaneous resolution, even though the variables and factors related to the viral clearance are not yet fully established. The study of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Spanish |
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Universidad de Antioquia
2023-10-01
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| Series: | Iatreia |
| Subjects: | |
| Online Access: | https://revistas.udea.edu.co/index.php/iatreia/article/view/350322 |
| _version_ | 1797665800875671552 |
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| author | Maria Fernanda Saavedra-Chacón María Cristina Navas Neys Suárez-Díaz Jose Roberto Uribe-Delgado |
| author_facet | Maria Fernanda Saavedra-Chacón María Cristina Navas Neys Suárez-Díaz Jose Roberto Uribe-Delgado |
| author_sort | Maria Fernanda Saavedra-Chacón |
| collection | DOAJ |
| description | The hepatitis C virus (HCV) is still one of the leading causes of chronic hepatitis in the western world. Between 15% to 40% of the people acutely infected achieve spontaneous resolution, even though the variables and factors related to the viral clearance are not yet fully established. The study of the physiopathological mechanisms of the HCV is essential for the identification of the factors related either to spontaneous resolution or persistence of the viral infection. Some studies have found out variables from the host associated with this outcome, including the interleukin 28 (IL-28B) gene polymorphisms. This gene codifies the lambda 3 interferon (IFNL3). The purpose of this article is to perform a literature review of the physiopathology of HCV infection, describe the evidence of the role of the IL28 gene polymorphisms, and their impact in the spontaneous virus clearance and other aspects of the natural history and treatment of the viral infection. |
| first_indexed | 2024-03-11T19:49:15Z |
| format | Article |
| id | doaj.art-40c230f1761f4e4fb2869440b9da5081 |
| institution | Directory Open Access Journal |
| issn | 0121-0793 2011-7965 |
| language | Spanish |
| last_indexed | 2024-03-11T19:49:15Z |
| publishDate | 2023-10-01 |
| publisher | Universidad de Antioquia |
| record_format | Article |
| series | Iatreia |
| spelling | doaj.art-40c230f1761f4e4fb2869440b9da50812023-10-05T13:13:22ZspaUniversidad de AntioquiaIatreia0121-07932011-79652023-10-0136455056110.17533/udea.iatreia.213Genetic Susceptibility and Viral Clearance of Hepatitis C Virus infectionMaria Fernanda Saavedra-Chacón0https://orcid.org/0000-0003-1191-4361María Cristina Navas1https://orcid.org/0000-0003-2610-9306Neys Suárez-Díaz2https://orcid.org/0000-0002-6800-4011Jose Roberto Uribe-Delgado3https://orcid.org/0000-0001-5996-5593Universidad de Antioquia, Medellín, ColombiaUniversidad de Antioquia, Medellín, ColombiaUniversidad Industrial de Santander. Bucaramanga, ColombiaUniversidad de Antioquia, Medellín, ColombiaThe hepatitis C virus (HCV) is still one of the leading causes of chronic hepatitis in the western world. Between 15% to 40% of the people acutely infected achieve spontaneous resolution, even though the variables and factors related to the viral clearance are not yet fully established. The study of the physiopathological mechanisms of the HCV is essential for the identification of the factors related either to spontaneous resolution or persistence of the viral infection. Some studies have found out variables from the host associated with this outcome, including the interleukin 28 (IL-28B) gene polymorphisms. This gene codifies the lambda 3 interferon (IFNL3). The purpose of this article is to perform a literature review of the physiopathology of HCV infection, describe the evidence of the role of the IL28 gene polymorphisms, and their impact in the spontaneous virus clearance and other aspects of the natural history and treatment of the viral infection.https://revistas.udea.edu.co/index.php/iatreia/article/view/350322hepatitis cimmunityinnatephysiopathologypolymorphismgenetic |
| spellingShingle | Maria Fernanda Saavedra-Chacón María Cristina Navas Neys Suárez-Díaz Jose Roberto Uribe-Delgado Genetic Susceptibility and Viral Clearance of Hepatitis C Virus infection Iatreia hepatitis c immunity innate physiopathology polymorphism genetic |
| title | Genetic Susceptibility and Viral Clearance of Hepatitis C Virus infection |
| title_full | Genetic Susceptibility and Viral Clearance of Hepatitis C Virus infection |
| title_fullStr | Genetic Susceptibility and Viral Clearance of Hepatitis C Virus infection |
| title_full_unstemmed | Genetic Susceptibility and Viral Clearance of Hepatitis C Virus infection |
| title_short | Genetic Susceptibility and Viral Clearance of Hepatitis C Virus infection |
| title_sort | genetic susceptibility and viral clearance of hepatitis c virus infection |
| topic | hepatitis c immunity innate physiopathology polymorphism genetic |
| url | https://revistas.udea.edu.co/index.php/iatreia/article/view/350322 |
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