Association of Plasma Lipopolysaccharide-Binding Protein Concentration with Dietary Factors, Gut Microbiota, and Health Status in the Japanese General Adult Population: A Cross-Sectional Study
The influx of intestinal bacteria-derived lipopolysaccharide (LPS) into the blood has attracted attention as a cause of diseases. The aim of this study is investigating the associations between the influx of LPS, dietary factors, gut microbiota, and health status in the general adult population. Foo...
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MDPI AG
2023-02-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/2/250 |
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| author | Nobuo Fuke Takahiro Yamashita Sunao Shimizu Mai Matsumoto Kaori Sawada Songee Jung Itoyo Tokuda Mina Misawa Shigenori Suzuki Yusuke Ushida Tatsuya Mikami Ken Itoh Hiroyuki Suganuma |
| author_facet | Nobuo Fuke Takahiro Yamashita Sunao Shimizu Mai Matsumoto Kaori Sawada Songee Jung Itoyo Tokuda Mina Misawa Shigenori Suzuki Yusuke Ushida Tatsuya Mikami Ken Itoh Hiroyuki Suganuma |
| author_sort | Nobuo Fuke |
| collection | DOAJ |
| description | The influx of intestinal bacteria-derived lipopolysaccharide (LPS) into the blood has attracted attention as a cause of diseases. The aim of this study is investigating the associations between the influx of LPS, dietary factors, gut microbiota, and health status in the general adult population. Food/nutrient intake, gut microbiota, health status and plasma LPS-binding protein (LBP; LPS exposure indicator) were measured in 896 residents (58.1% female, mean age 54.7 years) of the rural Iwaki district of Japan, and each correlation was analyzed. As the results, plasma LBP concentration correlated with physical (right/left arms’ muscle mass [<i>β</i> = −0.02, −0.03]), renal (plasma renin activity [<i>β</i> = 0.27], urine albumin creatinine ratio [<i>β</i> = 0.50]), adrenal cortical (cortisol [<i>β</i> = 0.14]), and thyroid function (free thyroxine [<i>β</i> = 0.05]), iron metabolism (serum iron [<i>β</i> = −0.14]), and markers of lifestyle-related diseases (all <i>Q</i>s < 0.20). Plasma LBP concentration were mainly negatively correlated with vegetables/their nutrients intake (all <i>βs</i> ≤ −0.004, <i>Q</i>s < 0.20). Plasma LBP concentration was positively correlated with the proportion of <i>Prevotella</i> (<i>β</i> = 0.32), <i>Megamonas</i> (<i>β</i> = 0.56), and <i>Streptococcus</i> (<i>β</i> = 0.65); and negatively correlated with <i>Roseburia</i> (<i>β</i> = −0.57) (all <i>Q</i>s < 0.20). Dietary factors correlated with plasma LBP concentration correlated with positively (all <i>β</i>s ≥ 0.07) or negatively (all <i>β</i>s ≤ −0.07) the proportion of these bacteria (all <i>Q</i>s < 0.20). Our results suggested that plasma LBP concentration in the Japanese general adult population was associated with various health issues, and that dietary habit was associated with plasma LBP concentration in relation to the intestinal bacteria. |
| first_indexed | 2024-03-11T08:26:04Z |
| format | Article |
| id | doaj.art-40c3e851f85746109c06fc2bf224a439 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T08:26:04Z |
| publishDate | 2023-02-01 |
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| series | Metabolites |
| spelling | doaj.art-40c3e851f85746109c06fc2bf224a4392023-11-16T22:04:59ZengMDPI AGMetabolites2218-19892023-02-0113225010.3390/metabo13020250Association of Plasma Lipopolysaccharide-Binding Protein Concentration with Dietary Factors, Gut Microbiota, and Health Status in the Japanese General Adult Population: A Cross-Sectional StudyNobuo Fuke0Takahiro Yamashita1Sunao Shimizu2Mai Matsumoto3Kaori Sawada4Songee Jung5Itoyo Tokuda6Mina Misawa7Shigenori Suzuki8Yusuke Ushida9Tatsuya Mikami10Ken Itoh11Hiroyuki Suganuma12Innovation Division, KAGOME Co., Ltd., 17 Nishitomiyama, Nasushiobara 329-2762, Tochigi, JapanInnovation Division, KAGOME Co., Ltd., 17 Nishitomiyama, Nasushiobara 329-2762, Tochigi, JapanInnovation Division, KAGOME Co., Ltd., 17 Nishitomiyama, Nasushiobara 329-2762, Tochigi, JapanInnovation Division, KAGOME Co., Ltd., 17 Nishitomiyama, Nasushiobara 329-2762, Tochigi, JapanInnovation Center for Health Promotion, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Aomori, JapanInnovation Center for Health Promotion, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Aomori, JapanInnovation Center for Health Promotion, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Aomori, JapanCenter of Innovation Research Initiatives Organization, Hirosaki University, 5 Zaifu-cho, Hirosaki 036-8562, Aomori, JapanInnovation Division, KAGOME Co., Ltd., 17 Nishitomiyama, Nasushiobara 329-2762, Tochigi, JapanInnovation Division, KAGOME Co., Ltd., 17 Nishitomiyama, Nasushiobara 329-2762, Tochigi, JapanInnovation Center for Health Promotion, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Aomori, JapanDepartment of Vegetable Life Science, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Aomori, JapanInnovation Division, KAGOME Co., Ltd., 17 Nishitomiyama, Nasushiobara 329-2762, Tochigi, JapanThe influx of intestinal bacteria-derived lipopolysaccharide (LPS) into the blood has attracted attention as a cause of diseases. The aim of this study is investigating the associations between the influx of LPS, dietary factors, gut microbiota, and health status in the general adult population. Food/nutrient intake, gut microbiota, health status and plasma LPS-binding protein (LBP; LPS exposure indicator) were measured in 896 residents (58.1% female, mean age 54.7 years) of the rural Iwaki district of Japan, and each correlation was analyzed. As the results, plasma LBP concentration correlated with physical (right/left arms’ muscle mass [<i>β</i> = −0.02, −0.03]), renal (plasma renin activity [<i>β</i> = 0.27], urine albumin creatinine ratio [<i>β</i> = 0.50]), adrenal cortical (cortisol [<i>β</i> = 0.14]), and thyroid function (free thyroxine [<i>β</i> = 0.05]), iron metabolism (serum iron [<i>β</i> = −0.14]), and markers of lifestyle-related diseases (all <i>Q</i>s < 0.20). Plasma LBP concentration were mainly negatively correlated with vegetables/their nutrients intake (all <i>βs</i> ≤ −0.004, <i>Q</i>s < 0.20). Plasma LBP concentration was positively correlated with the proportion of <i>Prevotella</i> (<i>β</i> = 0.32), <i>Megamonas</i> (<i>β</i> = 0.56), and <i>Streptococcus</i> (<i>β</i> = 0.65); and negatively correlated with <i>Roseburia</i> (<i>β</i> = −0.57) (all <i>Q</i>s < 0.20). Dietary factors correlated with plasma LBP concentration correlated with positively (all <i>β</i>s ≥ 0.07) or negatively (all <i>β</i>s ≤ −0.07) the proportion of these bacteria (all <i>Q</i>s < 0.20). Our results suggested that plasma LBP concentration in the Japanese general adult population was associated with various health issues, and that dietary habit was associated with plasma LBP concentration in relation to the intestinal bacteria.https://www.mdpi.com/2218-1989/13/2/250lipopolysaccharide-binding proteinmetabolic endotoxemiadiethealth statusgut microbiotacross-sectional study |
| spellingShingle | Nobuo Fuke Takahiro Yamashita Sunao Shimizu Mai Matsumoto Kaori Sawada Songee Jung Itoyo Tokuda Mina Misawa Shigenori Suzuki Yusuke Ushida Tatsuya Mikami Ken Itoh Hiroyuki Suganuma Association of Plasma Lipopolysaccharide-Binding Protein Concentration with Dietary Factors, Gut Microbiota, and Health Status in the Japanese General Adult Population: A Cross-Sectional Study Metabolites lipopolysaccharide-binding protein metabolic endotoxemia diet health status gut microbiota cross-sectional study |
| title | Association of Plasma Lipopolysaccharide-Binding Protein Concentration with Dietary Factors, Gut Microbiota, and Health Status in the Japanese General Adult Population: A Cross-Sectional Study |
| title_full | Association of Plasma Lipopolysaccharide-Binding Protein Concentration with Dietary Factors, Gut Microbiota, and Health Status in the Japanese General Adult Population: A Cross-Sectional Study |
| title_fullStr | Association of Plasma Lipopolysaccharide-Binding Protein Concentration with Dietary Factors, Gut Microbiota, and Health Status in the Japanese General Adult Population: A Cross-Sectional Study |
| title_full_unstemmed | Association of Plasma Lipopolysaccharide-Binding Protein Concentration with Dietary Factors, Gut Microbiota, and Health Status in the Japanese General Adult Population: A Cross-Sectional Study |
| title_short | Association of Plasma Lipopolysaccharide-Binding Protein Concentration with Dietary Factors, Gut Microbiota, and Health Status in the Japanese General Adult Population: A Cross-Sectional Study |
| title_sort | association of plasma lipopolysaccharide binding protein concentration with dietary factors gut microbiota and health status in the japanese general adult population a cross sectional study |
| topic | lipopolysaccharide-binding protein metabolic endotoxemia diet health status gut microbiota cross-sectional study |
| url | https://www.mdpi.com/2218-1989/13/2/250 |
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