A novel rhesus macaque model of Huntington’s disease recapitulates key neuropathological changes along with motor and cognitive decline
We created a new nonhuman primate model of the genetic neurodegenerative disorder Huntington’s disease (HD) by injecting a mixture of recombinant adeno-associated viral vectors, serotypes AAV2 and AAV2.retro, each expressing a fragment of human mutant HTT (mHTT) into the caudate and putamen of adult...
Main Authors: | Alison R Weiss, William A Liguore, Kristin Brandon, Xiaojie Wang, Zheng Liu, Jacqueline S Domire, Dana Button, Sathya Srinivasan, Christopher D Kroenke, Jodi L McBride |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2022-10-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/77568 |
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