Glucocorticoid Nanoparticles Show Full Therapeutic Efficacy in a Mouse Model of Acute Lung Injury and Concomitantly Reduce Adverse Effects

Glucocorticoid Nanoparticles Show Full Therapeutic Efficacy in a Mouse Model of Acute Lung Injury and Concomitantly Reduce Adverse Effects

Glucocorticoids (GCs) are widely used to treat inflammatory disorders such as acute lung injury (ALI). Here, we explored inorganic–organic hybrid nanoparticles (IOH-NPs) as a new delivery vehicle for GCs in a mouse model of ALI. Betamethasone (BMZ) encapsulated into IOH-NPs (BNPs) ameliorated the ma...

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Bibliographic Details
Main Authors: Gesa J. Albers, Agathe Amouret, Katrin Ciupka, Elena Montes-Cobos, Claus Feldmann, Holger M. Reichardt
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
acute lung injury
glucocorticoids
nanoparticles
myeloid cells
alveolar type II cells
muscle atrophy
Online Access:https://www.mdpi.com/1422-0067/24/23/16843

Internet

https://www.mdpi.com/1422-0067/24/23/16843

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