Oral field cancerization: Genetic profiling for a prevention strategy for oral potentially malignant disorders
Background: Oral cancer therapy, such as radiation or surgical treatment, has pernicious long-term effects that patients suffer throughout their life, the disability being considerable with delayed diagnosis. It is well known that many oral cancers develop from oral potentially malignant disorders (...
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| Format: | Article |
| Language: | English |
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Universitas Airlangga
2023-09-01
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| Series: | Dental Journal |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/MKG/article/view/41075 |
| _version_ | 1797301317252677632 |
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| author | Karlina Puspasari Togu Andrie Simon Pasaribu Meircurius Dwi Condro Surboyo Nurina Febriyanti Ayuningtyas Arvind Babu Rajendra Santosh Diah Savitri Ernawati |
| author_facet | Karlina Puspasari Togu Andrie Simon Pasaribu Meircurius Dwi Condro Surboyo Nurina Febriyanti Ayuningtyas Arvind Babu Rajendra Santosh Diah Savitri Ernawati |
| author_sort | Karlina Puspasari |
| collection | DOAJ |
| description | Background: Oral cancer therapy, such as radiation or surgical treatment, has pernicious long-term effects that patients suffer throughout their life, the disability being considerable with delayed diagnosis. It is well known that many oral cancers develop from oral potentially malignant disorders (OPMDs). Patients diagnosed with OPMDs may have an increased risk of developing cancer anywhere in the oral cavity. Early detection and intervention could be essential prevention strategies to inhibit oral cancer progression. OPMDs may not immediately develop into carcinoma. However, this condition provides a “field” of specific abnormalities wherein evolving altered genetic cells can be explained with the “field cancerization” concept. Purpose: This review aims to describe the “field cancerization” concept in oral cancer and OPMD, which is expected to contribute to a better clinical management strategy for oral cancer prevention. Review: “Oral field cancerization” describes oral cancers that develop in multifocal areas of pre-cancerous changes. It can be found as histologically abnormal tissue surrounding the tumor, suggesting that oral cancer often consists of multiple independent lesions. Conclusion: The oral field cancerization concept should prompt healthcare professionals to remind their patients that frequent oral examination with histological studies and molecular testing is mandatory for those at high risk of developing malignancies. |
| first_indexed | 2024-03-07T23:19:46Z |
| format | Article |
| id | doaj.art-40c6aea4f2474946a05f596ed8db01e3 |
| institution | Directory Open Access Journal |
| issn | 1978-3728 2442-9740 |
| language | English |
| last_indexed | 2024-03-07T23:19:46Z |
| publishDate | 2023-09-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Dental Journal |
| spelling | doaj.art-40c6aea4f2474946a05f596ed8db01e32024-02-21T06:32:15ZengUniversitas AirlanggaDental Journal1978-37282442-97402023-09-0156318919610.20473/j.djmkg.v56.i3.p189-19639146Oral field cancerization: Genetic profiling for a prevention strategy for oral potentially malignant disordersKarlina Puspasari0Togu Andrie Simon Pasaribu1Meircurius Dwi Condro Surboyo2https://orcid.org/0000-0002-6052-2287Nurina Febriyanti Ayuningtyas3https://orcid.org/0000-0003-4403-6542Arvind Babu Rajendra Santosh4https://orcid.org/0000-0001-6587-8672Diah Savitri Ernawati5https://orcid.org/0000-0002-4288-3222Faculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaFaculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaFaculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaFaculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaFaculty of Medical Sciences, The University of The West Indies. Mona Campus, Kingston, JamaicaFaculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaBackground: Oral cancer therapy, such as radiation or surgical treatment, has pernicious long-term effects that patients suffer throughout their life, the disability being considerable with delayed diagnosis. It is well known that many oral cancers develop from oral potentially malignant disorders (OPMDs). Patients diagnosed with OPMDs may have an increased risk of developing cancer anywhere in the oral cavity. Early detection and intervention could be essential prevention strategies to inhibit oral cancer progression. OPMDs may not immediately develop into carcinoma. However, this condition provides a “field” of specific abnormalities wherein evolving altered genetic cells can be explained with the “field cancerization” concept. Purpose: This review aims to describe the “field cancerization” concept in oral cancer and OPMD, which is expected to contribute to a better clinical management strategy for oral cancer prevention. Review: “Oral field cancerization” describes oral cancers that develop in multifocal areas of pre-cancerous changes. It can be found as histologically abnormal tissue surrounding the tumor, suggesting that oral cancer often consists of multiple independent lesions. Conclusion: The oral field cancerization concept should prompt healthcare professionals to remind their patients that frequent oral examination with histological studies and molecular testing is mandatory for those at high risk of developing malignancies.https://e-journal.unair.ac.id/MKG/article/view/41075genetically altered fieldoral canceroral field cancerizationoral potentially malignant disorders |
| spellingShingle | Karlina Puspasari Togu Andrie Simon Pasaribu Meircurius Dwi Condro Surboyo Nurina Febriyanti Ayuningtyas Arvind Babu Rajendra Santosh Diah Savitri Ernawati Oral field cancerization: Genetic profiling for a prevention strategy for oral potentially malignant disorders Dental Journal genetically altered field oral cancer oral field cancerization oral potentially malignant disorders |
| title | Oral field cancerization: Genetic profiling for a prevention strategy for oral potentially malignant disorders |
| title_full | Oral field cancerization: Genetic profiling for a prevention strategy for oral potentially malignant disorders |
| title_fullStr | Oral field cancerization: Genetic profiling for a prevention strategy for oral potentially malignant disorders |
| title_full_unstemmed | Oral field cancerization: Genetic profiling for a prevention strategy for oral potentially malignant disorders |
| title_short | Oral field cancerization: Genetic profiling for a prevention strategy for oral potentially malignant disorders |
| title_sort | oral field cancerization genetic profiling for a prevention strategy for oral potentially malignant disorders |
| topic | genetically altered field oral cancer oral field cancerization oral potentially malignant disorders |
| url | https://e-journal.unair.ac.id/MKG/article/view/41075 |
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