Orthogonal control of mean and variability of endogenous genes in a human cell line
Stochastic fluctuations at the transcriptional level contribute to heterogeneity in isogenic cell populations. Here, the authors engineer TuNR which modulates the variability in gene expression of endogenous human genes independent of their mean expression.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20467-8 |
| _version_ | 1818997505760690176 |
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| author | Alain R. Bonny João Pedro Fonseca Jesslyn E. Park Hana El-Samad |
| author_facet | Alain R. Bonny João Pedro Fonseca Jesslyn E. Park Hana El-Samad |
| author_sort | Alain R. Bonny |
| collection | DOAJ |
| description | Stochastic fluctuations at the transcriptional level contribute to heterogeneity in isogenic cell populations. Here, the authors engineer TuNR which modulates the variability in gene expression of endogenous human genes independent of their mean expression. |
| first_indexed | 2024-12-20T21:46:42Z |
| format | Article |
| id | doaj.art-40c72744eec947a8be9ff201dea8efdf |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:46:42Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-40c72744eec947a8be9ff201dea8efdf2022-12-21T19:25:40ZengNature PortfolioNature Communications2041-17232021-01-011211910.1038/s41467-020-20467-8Orthogonal control of mean and variability of endogenous genes in a human cell lineAlain R. Bonny0João Pedro Fonseca1Jesslyn E. Park2Hana El-Samad3Department of Biochemistry and Biophysics, University of California, San FranciscoDepartment of Biochemistry and Biophysics, University of California, San FranciscoDepartment of Biochemistry and Biophysics, University of California, San FranciscoDepartment of Biochemistry and Biophysics, University of California, San FranciscoStochastic fluctuations at the transcriptional level contribute to heterogeneity in isogenic cell populations. Here, the authors engineer TuNR which modulates the variability in gene expression of endogenous human genes independent of their mean expression.https://doi.org/10.1038/s41467-020-20467-8 |
| spellingShingle | Alain R. Bonny João Pedro Fonseca Jesslyn E. Park Hana El-Samad Orthogonal control of mean and variability of endogenous genes in a human cell line Nature Communications |
| title | Orthogonal control of mean and variability of endogenous genes in a human cell line |
| title_full | Orthogonal control of mean and variability of endogenous genes in a human cell line |
| title_fullStr | Orthogonal control of mean and variability of endogenous genes in a human cell line |
| title_full_unstemmed | Orthogonal control of mean and variability of endogenous genes in a human cell line |
| title_short | Orthogonal control of mean and variability of endogenous genes in a human cell line |
| title_sort | orthogonal control of mean and variability of endogenous genes in a human cell line |
| url | https://doi.org/10.1038/s41467-020-20467-8 |
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