Amygdala reactivity to sad faces in preschool children: An early neural marker of persistent negative affect
Background: Elevated negative affect is a highly salient risk factor for later internalizing disorders. Very little is known about the early neurobiological correlates of negative affect and whether they associate with developmental changes in negative emotion. Such information may prove critical fo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-02-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929315300293 |
| _version_ | 1819021509915574272 |
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| author | Michael S. Gaffrey Deanna M. Barch Joan L. Luby |
| author_facet | Michael S. Gaffrey Deanna M. Barch Joan L. Luby |
| author_sort | Michael S. Gaffrey |
| collection | DOAJ |
| description | Background: Elevated negative affect is a highly salient risk factor for later internalizing disorders. Very little is known about the early neurobiological correlates of negative affect and whether they associate with developmental changes in negative emotion. Such information may prove critical for identifying children deviating from normative developmental trajectories of negative affect and at increased risk for later internalizing disorders. The current study examined the relationship between amygdala activity and negative affect measured concurrently and approximately 12 months later in preschool-age children.
Method: Amygdala activity was assessed using functional magnetic resonance imaging in 31 medication-naive preschool age children. Negative affect was measured using parent report both at the time of scan and 12 months later.
Results: Negative affect at baseline was positively correlated with right amygdala activity to sad faces, right amygdala activity to happy faces, and left amygdala activity to happy faces. Right amygdala activity to sad faces also positively predicted parent-reported negative affect 12 months later even when negative affect reported at baseline was controlled.
Conclusions: The current findings provide preliminary evidence for amygdala activity as a potential biomarker of persistent negative affect during early childhood and suggest future work examining the origins and long-term implications of this relationship is necessary. |
| first_indexed | 2024-12-21T04:08:14Z |
| format | Article |
| id | doaj.art-40c7959115534123955311b8b43df385 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 1878-9307 |
| language | English |
| last_indexed | 2024-12-21T04:08:14Z |
| publishDate | 2016-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-40c7959115534123955311b8b43df3852022-12-21T19:16:33ZengElsevierDevelopmental Cognitive Neuroscience1878-92931878-93072016-02-0117C9410010.1016/j.dcn.2015.12.015Amygdala reactivity to sad faces in preschool children: An early neural marker of persistent negative affectMichael S. Gaffrey0Deanna M. Barch1Joan L. Luby2Washington University in St. Louis, Department of Psychiatry, Campus Box: 8511, 660 South Euclid Avenue, Saint Louis, MO 63110, United StatesWashington University in St. Louis, Department of Psychiatry, Campus Box: 8511, 660 South Euclid Avenue, Saint Louis, MO 63110, United StatesWashington University in St. Louis, Department of Psychiatry, Campus Box: 8511, 660 South Euclid Avenue, Saint Louis, MO 63110, United StatesBackground: Elevated negative affect is a highly salient risk factor for later internalizing disorders. Very little is known about the early neurobiological correlates of negative affect and whether they associate with developmental changes in negative emotion. Such information may prove critical for identifying children deviating from normative developmental trajectories of negative affect and at increased risk for later internalizing disorders. The current study examined the relationship between amygdala activity and negative affect measured concurrently and approximately 12 months later in preschool-age children. Method: Amygdala activity was assessed using functional magnetic resonance imaging in 31 medication-naive preschool age children. Negative affect was measured using parent report both at the time of scan and 12 months later. Results: Negative affect at baseline was positively correlated with right amygdala activity to sad faces, right amygdala activity to happy faces, and left amygdala activity to happy faces. Right amygdala activity to sad faces also positively predicted parent-reported negative affect 12 months later even when negative affect reported at baseline was controlled. Conclusions: The current findings provide preliminary evidence for amygdala activity as a potential biomarker of persistent negative affect during early childhood and suggest future work examining the origins and long-term implications of this relationship is necessary.http://www.sciencedirect.com/science/article/pii/S1878929315300293AmygdalaNegative affectfMRIIrritabilityChildDevelopment |
| spellingShingle | Michael S. Gaffrey Deanna M. Barch Joan L. Luby Amygdala reactivity to sad faces in preschool children: An early neural marker of persistent negative affect Developmental Cognitive Neuroscience Amygdala Negative affect fMRI Irritability Child Development |
| title | Amygdala reactivity to sad faces in preschool children: An early neural marker of persistent negative affect |
| title_full | Amygdala reactivity to sad faces in preschool children: An early neural marker of persistent negative affect |
| title_fullStr | Amygdala reactivity to sad faces in preschool children: An early neural marker of persistent negative affect |
| title_full_unstemmed | Amygdala reactivity to sad faces in preschool children: An early neural marker of persistent negative affect |
| title_short | Amygdala reactivity to sad faces in preschool children: An early neural marker of persistent negative affect |
| title_sort | amygdala reactivity to sad faces in preschool children an early neural marker of persistent negative affect |
| topic | Amygdala Negative affect fMRI Irritability Child Development |
| url | http://www.sciencedirect.com/science/article/pii/S1878929315300293 |
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