Associations between anxiety, depression with migraine, and migraine-related burdens
BackgroundAnxiety and depression are the most common psychiatric comorbidities in migraine, but their impact on the risk of developing migraine and their gender and age differences are unclear, and research on their associations with migraine-related burdens are limited.ObjectiveTo systematically ex...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1090878/full |
| _version_ | 1797839998870880256 |
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| author | Shaojie Duan Shaojie Duan Zhiying Ren Zhiying Ren Hui Xia Hui Xia Ziyao Wang Ziyao Wang Tao Zheng Tao Zheng Guanglu Li Guanglu Li Lei Liu Zunjing Liu |
| author_facet | Shaojie Duan Shaojie Duan Zhiying Ren Zhiying Ren Hui Xia Hui Xia Ziyao Wang Ziyao Wang Tao Zheng Tao Zheng Guanglu Li Guanglu Li Lei Liu Zunjing Liu |
| author_sort | Shaojie Duan |
| collection | DOAJ |
| description | BackgroundAnxiety and depression are the most common psychiatric comorbidities in migraine, but their impact on the risk of developing migraine and their gender and age differences are unclear, and research on their associations with migraine-related burdens are limited.ObjectiveTo systematically explore the association between anxiety and depression with migraine and migraine-related burdens, including the risk of developing migraine, as well as migraine frequency, severity, disability, headache impact, quality of life and sleep quality.MethodsA total of 170 migraineurs and 85 sex-and age-matched healthy control subjects were recruited consecutively for this study. Anxiety and depression were assessed using Zung’s Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS), respectively. Logistic regression and linear regression analyses were used to explore the associations between anxiety and depression with migraine and its burdens. The receiver operating characteristic (ROC) curve was used to evaluate the predictive value of SAS score and SDS score on migraine and its severe burdens.ResultsAfter adjusting for confounders, anxiety and depression remained significantly associated with an increased risk of developing migraine, with odds ratios of 5.186 (95% CI:1.755–15.322) and 3.147 (95% CI:1.387–7.141), respectively. Meanwhile, there were significant additive interactions between the association of anxiety and depression with the risk of developing migraine in gender and age (P for interaction <0.05), and the stronger correlations were found in participants with an age ≤ 36 years old and females. In addition, anxiety and depression were significantly independently associated with the migraine frequency, severity, disability, headache impact, quality of life, and sleep quality in migraine patients (P trend <0.05). The area under the ROC curve (AUC) of SAS score in predicting developing migraine was significantly higher than that of SDS score [0.749 (95% CI: 0.691–0.801) vs. 0.633 (95% CI: 0.571–0.692), p < 0.0001].ConclusionAnxiety and depression were significantly independently associated with the increased risk of migraine and migraine-related burdens. Enhanced assessment of SAS score and SDS score is of great clinical value for the early prevention and treatment of migraine and its burdens. |
| first_indexed | 2024-04-09T16:07:16Z |
| format | Article |
| id | doaj.art-40c8372180dc4665a13879abf3ed602b |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T16:07:16Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-40c8372180dc4665a13879abf3ed602b2023-04-25T04:28:25ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-04-011410.3389/fneur.2023.10908781090878Associations between anxiety, depression with migraine, and migraine-related burdensShaojie Duan0Shaojie Duan1Zhiying Ren2Zhiying Ren3Hui Xia4Hui Xia5Ziyao Wang6Ziyao Wang7Tao Zheng8Tao Zheng9Guanglu Li10Guanglu Li11Lei Liu12Zunjing Liu13Department of Geriatrics, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, ChinaGraduate School of Beijing University of Chinese Medicine, Beijing, ChinaGraduate School of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, China-Japan Friendship Hospital, Beijing, ChinaGraduate School of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, China-Japan Friendship Hospital, Beijing, ChinaGraduate School of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, China-Japan Friendship Hospital, Beijing, ChinaGraduate School of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, China-Japan Friendship Hospital, Beijing, ChinaGraduate School of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Neurology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Neurology, Peking University People’s Hospital, Beijing, ChinaBackgroundAnxiety and depression are the most common psychiatric comorbidities in migraine, but their impact on the risk of developing migraine and their gender and age differences are unclear, and research on their associations with migraine-related burdens are limited.ObjectiveTo systematically explore the association between anxiety and depression with migraine and migraine-related burdens, including the risk of developing migraine, as well as migraine frequency, severity, disability, headache impact, quality of life and sleep quality.MethodsA total of 170 migraineurs and 85 sex-and age-matched healthy control subjects were recruited consecutively for this study. Anxiety and depression were assessed using Zung’s Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS), respectively. Logistic regression and linear regression analyses were used to explore the associations between anxiety and depression with migraine and its burdens. The receiver operating characteristic (ROC) curve was used to evaluate the predictive value of SAS score and SDS score on migraine and its severe burdens.ResultsAfter adjusting for confounders, anxiety and depression remained significantly associated with an increased risk of developing migraine, with odds ratios of 5.186 (95% CI:1.755–15.322) and 3.147 (95% CI:1.387–7.141), respectively. Meanwhile, there were significant additive interactions between the association of anxiety and depression with the risk of developing migraine in gender and age (P for interaction <0.05), and the stronger correlations were found in participants with an age ≤ 36 years old and females. In addition, anxiety and depression were significantly independently associated with the migraine frequency, severity, disability, headache impact, quality of life, and sleep quality in migraine patients (P trend <0.05). The area under the ROC curve (AUC) of SAS score in predicting developing migraine was significantly higher than that of SDS score [0.749 (95% CI: 0.691–0.801) vs. 0.633 (95% CI: 0.571–0.692), p < 0.0001].ConclusionAnxiety and depression were significantly independently associated with the increased risk of migraine and migraine-related burdens. Enhanced assessment of SAS score and SDS score is of great clinical value for the early prevention and treatment of migraine and its burdens.https://www.frontiersin.org/articles/10.3389/fneur.2023.1090878/fullanxietydepressionmigrainemigraine burdenassociation |
| spellingShingle | Shaojie Duan Shaojie Duan Zhiying Ren Zhiying Ren Hui Xia Hui Xia Ziyao Wang Ziyao Wang Tao Zheng Tao Zheng Guanglu Li Guanglu Li Lei Liu Zunjing Liu Associations between anxiety, depression with migraine, and migraine-related burdens Frontiers in Neurology anxiety depression migraine migraine burden association |
| title | Associations between anxiety, depression with migraine, and migraine-related burdens |
| title_full | Associations between anxiety, depression with migraine, and migraine-related burdens |
| title_fullStr | Associations between anxiety, depression with migraine, and migraine-related burdens |
| title_full_unstemmed | Associations between anxiety, depression with migraine, and migraine-related burdens |
| title_short | Associations between anxiety, depression with migraine, and migraine-related burdens |
| title_sort | associations between anxiety depression with migraine and migraine related burdens |
| topic | anxiety depression migraine migraine burden association |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1090878/full |
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