Multi-objective optimization via evolutionary algorithm (MOVEA) for high-definition transcranial electrical stimulation of the human brain
Designing a transcranial electrical stimulation (tES) strategy requires considering multiple objectives, such as intensity in the target area, focality, stimulation depth, and avoidance zone. These objectives are often mutually exclusive. In this paper, we propose a general framework, called multi-o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811923004822 |
| _version_ | 1797683192925257728 |
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| author | Mo Wang Kexin Lou Zeming Liu Pengfei Wei Quanying Liu |
| author_facet | Mo Wang Kexin Lou Zeming Liu Pengfei Wei Quanying Liu |
| author_sort | Mo Wang |
| collection | DOAJ |
| description | Designing a transcranial electrical stimulation (tES) strategy requires considering multiple objectives, such as intensity in the target area, focality, stimulation depth, and avoidance zone. These objectives are often mutually exclusive. In this paper, we propose a general framework, called multi-objective optimization via evolutionary algorithm (MOVEA), which solves the non-convex optimization problem in designing tES strategies without a predefined direction. MOVEA enables simultaneous optimization of multiple targets through Pareto optimization, generating a Pareto front after a single run without manual weight adjustment and allowing easy expansion to more targets. This Pareto front consists of optimal solutions that meet various requirements while respecting trade-off relationships between conflicting objectives such as intensity and focality. MOVEA is versatile and suitable for both transcranial alternating current stimulation (tACS) and transcranial temporal interference stimulation (tTIS) based on high definition (HD) and two-pair systems. We comprehensively compared tACS and tTIS in terms of intensity, focality, and steerability for targets at different depths. Our findings reveal that tTIS enhances focality by reducing activated volume outside the target by 60%. HD-tTIS and HD-tDCS can achieve equivalent maximum intensities, surpassing those of two-pair tTIS, such as 0.51 V/m under HD-tACS/HD-tTIS and 0.42 V/m under two-pair tTIS for the motor area as a target. Analysis of variance in eight subjects highlights individual differences in both optimal stimulation policies and outcomes for tACS and tTIS, emphasizing the need for personalized stimulation protocols. These findings provide guidance for designing appropriate stimulation strategies for tACS and tTIS. MOVEA facilitates the optimization of tES based on specific objectives and constraints, advancing tTIS and tACS-based neuromodulation in understanding the causal relationship between brain regions and cognitive functions and treating diseases. The code for MOVEA is available at https://github.com/ncclabsustech/MOVEA. |
| first_indexed | 2024-03-12T00:10:59Z |
| format | Article |
| id | doaj.art-40c923e78eba4a4aa61c407d8c06d6f3 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-03-12T00:10:59Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-40c923e78eba4a4aa61c407d8c06d6f32023-09-16T05:28:55ZengElsevierNeuroImage1095-95722023-10-01280120331Multi-objective optimization via evolutionary algorithm (MOVEA) for high-definition transcranial electrical stimulation of the human brainMo Wang0Kexin Lou1Zeming Liu2Pengfei Wei3Quanying Liu4Department of Biomedical Engineering, Southern University of Science and Technology, ChinaDepartment of Biomedical Engineering, Southern University of Science and Technology, China; School of Electrical Engineering and Computer Science, University of Queensland, AustraliaDepartment of Biomedical Engineering, Southern University of Science and Technology, ChinaShenzhen Institute of Advanced Technology, Chinese Academy of Sciences, ChinaDepartment of Biomedical Engineering, Southern University of Science and Technology, China; Corresponding author.Designing a transcranial electrical stimulation (tES) strategy requires considering multiple objectives, such as intensity in the target area, focality, stimulation depth, and avoidance zone. These objectives are often mutually exclusive. In this paper, we propose a general framework, called multi-objective optimization via evolutionary algorithm (MOVEA), which solves the non-convex optimization problem in designing tES strategies without a predefined direction. MOVEA enables simultaneous optimization of multiple targets through Pareto optimization, generating a Pareto front after a single run without manual weight adjustment and allowing easy expansion to more targets. This Pareto front consists of optimal solutions that meet various requirements while respecting trade-off relationships between conflicting objectives such as intensity and focality. MOVEA is versatile and suitable for both transcranial alternating current stimulation (tACS) and transcranial temporal interference stimulation (tTIS) based on high definition (HD) and two-pair systems. We comprehensively compared tACS and tTIS in terms of intensity, focality, and steerability for targets at different depths. Our findings reveal that tTIS enhances focality by reducing activated volume outside the target by 60%. HD-tTIS and HD-tDCS can achieve equivalent maximum intensities, surpassing those of two-pair tTIS, such as 0.51 V/m under HD-tACS/HD-tTIS and 0.42 V/m under two-pair tTIS for the motor area as a target. Analysis of variance in eight subjects highlights individual differences in both optimal stimulation policies and outcomes for tACS and tTIS, emphasizing the need for personalized stimulation protocols. These findings provide guidance for designing appropriate stimulation strategies for tACS and tTIS. MOVEA facilitates the optimization of tES based on specific objectives and constraints, advancing tTIS and tACS-based neuromodulation in understanding the causal relationship between brain regions and cognitive functions and treating diseases. The code for MOVEA is available at https://github.com/ncclabsustech/MOVEA.http://www.sciencedirect.com/science/article/pii/S1053811923004822Transcranial electrical stimulation (tES)Multi-objective optimizationEvolutionary algorithmTranscranial temporal interference stimulation (tTIS)Transcranial alternating current stimulation (tACS)Personalized neuromodulation |
| spellingShingle | Mo Wang Kexin Lou Zeming Liu Pengfei Wei Quanying Liu Multi-objective optimization via evolutionary algorithm (MOVEA) for high-definition transcranial electrical stimulation of the human brain NeuroImage Transcranial electrical stimulation (tES) Multi-objective optimization Evolutionary algorithm Transcranial temporal interference stimulation (tTIS) Transcranial alternating current stimulation (tACS) Personalized neuromodulation |
| title | Multi-objective optimization via evolutionary algorithm (MOVEA) for high-definition transcranial electrical stimulation of the human brain |
| title_full | Multi-objective optimization via evolutionary algorithm (MOVEA) for high-definition transcranial electrical stimulation of the human brain |
| title_fullStr | Multi-objective optimization via evolutionary algorithm (MOVEA) for high-definition transcranial electrical stimulation of the human brain |
| title_full_unstemmed | Multi-objective optimization via evolutionary algorithm (MOVEA) for high-definition transcranial electrical stimulation of the human brain |
| title_short | Multi-objective optimization via evolutionary algorithm (MOVEA) for high-definition transcranial electrical stimulation of the human brain |
| title_sort | multi objective optimization via evolutionary algorithm movea for high definition transcranial electrical stimulation of the human brain |
| topic | Transcranial electrical stimulation (tES) Multi-objective optimization Evolutionary algorithm Transcranial temporal interference stimulation (tTIS) Transcranial alternating current stimulation (tACS) Personalized neuromodulation |
| url | http://www.sciencedirect.com/science/article/pii/S1053811923004822 |
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