Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy

Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy

Abstract Activation of hypoxia‐inducible factor 1α (HIF1α) contributes to blood‐retinal barrier (BRB) breakdown and pathological neovascularization responsible for vision loss in ischemic retinal diseases. During disease progression, mitochondrial biology is altered to adapt to the ischemic environm...

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Bibliographic Details
Main Authors: So‐Yeon Kim, Nam Gu Yoon, Jin Young Im, Ji Hye Lee, Juhee Kim, Yujin Jeon, Young Jae Choi, Jong‐Hwa Lee, Akiyoshi Uemura, Dong Ho Park, Byoung Heon Kang
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Advanced Science
Subjects:
calcium
calpain‐1
hypoxia‐inducible factor 1α (HIF1α)
ischemic retinopathy
mitochondrial permeability transition pore (mPTP)
tumor necrosis factor receptor‐associated protein 1 (TRAP1)
Online Access:https://doi.org/10.1002/advs.202302776

Internet

https://doi.org/10.1002/advs.202302776

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