<italic toggle="yes">Aspergillus</italic> Cell Wall Chitin Induces Anti- and Proinflammatory Cytokines in Human PBMCs via the Fc-γ Receptor/Syk/PI3K Pathway

<italic toggle="yes">Aspergillus</italic> Cell Wall Chitin Induces Anti- and Proinflammatory Cytokines in Human PBMCs via the Fc-γ Receptor/Syk/PI3K Pathway

ABSTRACT Chitin is an important cell wall component of Aspergillus fumigatus conidia, of which hundreds are inhaled on a daily basis. Previous studies have shown that chitin has both anti- and proinflammatory properties; however the exact mechanisms determining the inflammatory signature of chitin a...

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Main Authors: K. L. Becker, V. Aimanianda, X. Wang, M. S. Gresnigt, A. Ammerdorffer, C. W. Jacobs, R. P. Gazendam, L. A. B. Joosten, M. G. Netea, J. P. Latgé, F. L. van de Veerdonk
Format: Article
Language:English
Published: American Society for Microbiology 2016-07-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.01823-15

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