Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres
Selective internal radiation therapy (SIRT) is a treatment modality for liver tumours during which radioactive microspheres are injected into the hepatic arterial tree. Holmium-166 (<sup>166</sup>Ho) microspheres used for SIRT can be visualized and quantified with MRI, potentially allowi...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/21/5462 |
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| author | Joey Roosen Mark J. Arntz Marcel J. R. Janssen Sytse F. de Jong Jurgen J. Fütterer Christiaan G. Overduin J. Frank W. Nijsen |
| author_facet | Joey Roosen Mark J. Arntz Marcel J. R. Janssen Sytse F. de Jong Jurgen J. Fütterer Christiaan G. Overduin J. Frank W. Nijsen |
| author_sort | Joey Roosen |
| collection | DOAJ |
| description | Selective internal radiation therapy (SIRT) is a treatment modality for liver tumours during which radioactive microspheres are injected into the hepatic arterial tree. Holmium-166 (<sup>166</sup>Ho) microspheres used for SIRT can be visualized and quantified with MRI, potentially allowing for MRI guidance during SIRT. The purpose of this study was to investigate the MRI compatibility of two angiography catheters and a microcatheter typically used for SIRT, and to explore the detectability of <sup>166</sup>Ho microspheres in a flow phantom using near real-time MRI. MR safety tests were performed at a 3 T MRI system according to American Society for Testing of Materials standard test methods. To assess the near real-time detectability of <sup>166</sup>Ho microspheres, a flow phantom was placed in the MRI bore and perfused using a peristaltic pump, simulating the flow in the hepatic artery. Dynamic MR imaging was performed using a 2D FLASH sequence during injection of different concentrations of <sup>166</sup>Ho microspheres. In the safety assessment, no significant heating (ΔT<sub>max</sub> 0.7 °C) was found in any catheter, and no magnetic interaction was found in two out of three of the used catheters. Near real-time MRI visualization of <sup>166</sup>Ho microsphere administration was feasible and depended on holmium concentration and vascular flow speed. Finally, we demonstrate preliminary imaging examples on the in vivo catheter visibility and near real-time imaging during <sup>166</sup>Ho microsphere administration in an initial patient case treated with SIRT in a clinical 3 T MRI. These results support additional research to establish the feasibility and safety of this procedure in vivo and enable the further development of a personalized MRI-guided approach to SIRT. |
| first_indexed | 2024-03-10T06:05:24Z |
| format | Article |
| id | doaj.art-40ccb12fd39c43ba98bf1e35ec910439 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T06:05:24Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-40ccb12fd39c43ba98bf1e35ec9104392023-11-22T20:35:38ZengMDPI AGCancers2072-66942021-10-011321546210.3390/cancers13215462Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 MicrospheresJoey Roosen0Mark J. Arntz1Marcel J. R. Janssen2Sytse F. de Jong3Jurgen J. Fütterer4Christiaan G. Overduin5J. Frank W. Nijsen6Department of Medical Imaging, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The NetherlandsDepartment of Medical Imaging, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The NetherlandsDepartment of Medical Imaging, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The NetherlandsDepartment of Cardiothoracic Surgery, Radboud University Medical Center, 6525 GA Nijmegen, The NetherlandsDepartment of Medical Imaging, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The NetherlandsDepartment of Medical Imaging, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The NetherlandsDepartment of Medical Imaging, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The NetherlandsSelective internal radiation therapy (SIRT) is a treatment modality for liver tumours during which radioactive microspheres are injected into the hepatic arterial tree. Holmium-166 (<sup>166</sup>Ho) microspheres used for SIRT can be visualized and quantified with MRI, potentially allowing for MRI guidance during SIRT. The purpose of this study was to investigate the MRI compatibility of two angiography catheters and a microcatheter typically used for SIRT, and to explore the detectability of <sup>166</sup>Ho microspheres in a flow phantom using near real-time MRI. MR safety tests were performed at a 3 T MRI system according to American Society for Testing of Materials standard test methods. To assess the near real-time detectability of <sup>166</sup>Ho microspheres, a flow phantom was placed in the MRI bore and perfused using a peristaltic pump, simulating the flow in the hepatic artery. Dynamic MR imaging was performed using a 2D FLASH sequence during injection of different concentrations of <sup>166</sup>Ho microspheres. In the safety assessment, no significant heating (ΔT<sub>max</sub> 0.7 °C) was found in any catheter, and no magnetic interaction was found in two out of three of the used catheters. Near real-time MRI visualization of <sup>166</sup>Ho microsphere administration was feasible and depended on holmium concentration and vascular flow speed. Finally, we demonstrate preliminary imaging examples on the in vivo catheter visibility and near real-time imaging during <sup>166</sup>Ho microsphere administration in an initial patient case treated with SIRT in a clinical 3 T MRI. These results support additional research to establish the feasibility and safety of this procedure in vivo and enable the further development of a personalized MRI-guided approach to SIRT.https://www.mdpi.com/2072-6694/13/21/5462SIRTradioembolizationholmiumMRIsafetycompatible |
| spellingShingle | Joey Roosen Mark J. Arntz Marcel J. R. Janssen Sytse F. de Jong Jurgen J. Fütterer Christiaan G. Overduin J. Frank W. Nijsen Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres Cancers SIRT radioembolization holmium MRI safety compatible |
| title | Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres |
| title_full | Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres |
| title_fullStr | Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres |
| title_full_unstemmed | Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres |
| title_short | Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres |
| title_sort | development of an mri guided approach to selective internal radiation therapy using holmium 166 microspheres |
| topic | SIRT radioembolization holmium MRI safety compatible |
| url | https://www.mdpi.com/2072-6694/13/21/5462 |
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