HDL Cholesterol Efflux and the Complement System Are Linked in Systemic Lupus Erythematosus
Cholesterol efflux capacity (CEC), the ability of high-density lipoprotein (HDL) cholesterol to accept cholesterol from macrophages, has been linked to cardiovascular events. Systemic lupus erythematosus (SLE) is characterized by the consumption of complement (C) proteins and has been associated wit...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/16/5405 |
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| author | María García-González Fuensanta Gómez-Bernal Juan C. Quevedo-Abeledo Yolanda Fernández-Cladera Agustín F. González-Rivero Raquel López-Mejías Federico Díaz-González Miguel Á. González-Gay Iván Ferraz-Amaro |
| author_facet | María García-González Fuensanta Gómez-Bernal Juan C. Quevedo-Abeledo Yolanda Fernández-Cladera Agustín F. González-Rivero Raquel López-Mejías Federico Díaz-González Miguel Á. González-Gay Iván Ferraz-Amaro |
| author_sort | María García-González |
| collection | DOAJ |
| description | Cholesterol efflux capacity (CEC), the ability of high-density lipoprotein (HDL) cholesterol to accept cholesterol from macrophages, has been linked to cardiovascular events. Systemic lupus erythematosus (SLE) is characterized by the consumption of complement (C) proteins and has been associated with an increased risk of cardiovascular disease. CEC is reduced in SLE patients compared to controls. In the present work, our objective was to analyze whether the disruption of C influences CEC in patients with SLE. New-generation functional assays of the three pathways of the C system were performed in 207 patients with SLE. Additionally, serum levels of inactive (C1q, C2, C3, C4, and factor D) and activated (C3a) molecules, and regulators (C1-inhibitor and factor H) of C system were measured. CEC, using an in vitro assay, and lipoprotein serum concentrations were assessed. Multivariable linear regression analysis was performed to assess the relationship between C system and CEC. After full multivariable analysis, the alternative C cascade functional test showed a significant and negative relationship with CEC. This was also the case for C2 and C3, in which the associations were found to be positive and statistically significant, after adjustment for covariates. In conclusion, C system and CEC are interconnected in patients with SLE. |
| first_indexed | 2024-03-10T23:50:17Z |
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| id | doaj.art-40cde2d1947247fc935478716680a2e7 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T23:50:17Z |
| publishDate | 2023-08-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-40cde2d1947247fc935478716680a2e72023-11-19T01:41:49ZengMDPI AGJournal of Clinical Medicine2077-03832023-08-011216540510.3390/jcm12165405HDL Cholesterol Efflux and the Complement System Are Linked in Systemic Lupus ErythematosusMaría García-González0Fuensanta Gómez-Bernal1Juan C. Quevedo-Abeledo2Yolanda Fernández-Cladera3Agustín F. González-Rivero4Raquel López-Mejías5Federico Díaz-González6Miguel Á. González-Gay7Iván Ferraz-Amaro8Division of Rheumatology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Central Laboratory, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Rheumatology, Hospital Doctor Negrín, 35010 Las Palmas de Gran Canaria, SpainDivision of Central Laboratory, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Central Laboratory, Hospital Universitario de Canarias, 38320 Tenerife, SpainEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Instituto de Investigación sanitaria Marqués de Valdecilla (IDIVAL), 39011 Santander, SpainDivision of Rheumatology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Rheumatology, IIS-Fundación Jiménez Díaz, 28040 Madrid, SpainDivision of Rheumatology, Hospital Universitario de Canarias, 38320 Tenerife, SpainCholesterol efflux capacity (CEC), the ability of high-density lipoprotein (HDL) cholesterol to accept cholesterol from macrophages, has been linked to cardiovascular events. Systemic lupus erythematosus (SLE) is characterized by the consumption of complement (C) proteins and has been associated with an increased risk of cardiovascular disease. CEC is reduced in SLE patients compared to controls. In the present work, our objective was to analyze whether the disruption of C influences CEC in patients with SLE. New-generation functional assays of the three pathways of the C system were performed in 207 patients with SLE. Additionally, serum levels of inactive (C1q, C2, C3, C4, and factor D) and activated (C3a) molecules, and regulators (C1-inhibitor and factor H) of C system were measured. CEC, using an in vitro assay, and lipoprotein serum concentrations were assessed. Multivariable linear regression analysis was performed to assess the relationship between C system and CEC. After full multivariable analysis, the alternative C cascade functional test showed a significant and negative relationship with CEC. This was also the case for C2 and C3, in which the associations were found to be positive and statistically significant, after adjustment for covariates. In conclusion, C system and CEC are interconnected in patients with SLE.https://www.mdpi.com/2077-0383/12/16/5405cholesterol efflux capacitycomplement systemsystemic lupus erythematosus |
| spellingShingle | María García-González Fuensanta Gómez-Bernal Juan C. Quevedo-Abeledo Yolanda Fernández-Cladera Agustín F. González-Rivero Raquel López-Mejías Federico Díaz-González Miguel Á. González-Gay Iván Ferraz-Amaro HDL Cholesterol Efflux and the Complement System Are Linked in Systemic Lupus Erythematosus Journal of Clinical Medicine cholesterol efflux capacity complement system systemic lupus erythematosus |
| title | HDL Cholesterol Efflux and the Complement System Are Linked in Systemic Lupus Erythematosus |
| title_full | HDL Cholesterol Efflux and the Complement System Are Linked in Systemic Lupus Erythematosus |
| title_fullStr | HDL Cholesterol Efflux and the Complement System Are Linked in Systemic Lupus Erythematosus |
| title_full_unstemmed | HDL Cholesterol Efflux and the Complement System Are Linked in Systemic Lupus Erythematosus |
| title_short | HDL Cholesterol Efflux and the Complement System Are Linked in Systemic Lupus Erythematosus |
| title_sort | hdl cholesterol efflux and the complement system are linked in systemic lupus erythematosus |
| topic | cholesterol efflux capacity complement system systemic lupus erythematosus |
| url | https://www.mdpi.com/2077-0383/12/16/5405 |
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