Topical Chitosan-Based Thermo-Responsive Scaffold Provides Dexketoprofen Trometamol Controlled Release for 24 h Use
Chronic and non-healing wounds demand personalized and more effective therapies for treating complications and improving patient compliance. Concerning that, this work aims to develop a suitable chitosan-based thermo-responsive scaffold to provide 24 h controlled release of Dexketoprofen trometamol...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/12/2100 |
| _version_ | 1797501497880084480 |
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| author | Luis Castillo-Henríquez Pablo Sanabria-Espinoza Brayan Murillo-Castillo Gabriela Montes de Oca-Vásquez Diego Batista-Menezes Briner Calvo-Guzmán Nils Ramírez-Arguedas José Vega-Baudrit |
| author_facet | Luis Castillo-Henríquez Pablo Sanabria-Espinoza Brayan Murillo-Castillo Gabriela Montes de Oca-Vásquez Diego Batista-Menezes Briner Calvo-Guzmán Nils Ramírez-Arguedas José Vega-Baudrit |
| author_sort | Luis Castillo-Henríquez |
| collection | DOAJ |
| description | Chronic and non-healing wounds demand personalized and more effective therapies for treating complications and improving patient compliance. Concerning that, this work aims to develop a suitable chitosan-based thermo-responsive scaffold to provide 24 h controlled release of Dexketoprofen trometamol (DKT). Three formulation prototypes were developed using chitosan (F1), 2:1 chitosan: PVA (F2), and 1:1 chitosan:gelatin (F3). Compatibility tests were done by DSC, TG, and FT-IR. SEM was employed to examine the morphology of the surface and inner layers from the scaffolds. In vitro release studies were performed at 32 °C and 38 °C, and the profiles were later adjusted to different kinetic models for the best formulation. F3 showed the most controlled release of DKT at 32 °C for 24 h (77.75 ± 2.72%) and reduced the burst release in the initial 6 h (40.18 ± 1.00%). The formulation exhibited a lower critical solution temperature (LCST) at 34.96 °C, and due to this phase transition, an increased release was observed at 38 °C (88.52 ± 2.07% at 12 h). The release profile for this formulation fits with Hixson–Crowell and Korsmeyer–Peppas kinetic models at both temperatures. Therefore, the developed scaffold for DKT delivery performs adequate controlled release, thereby; it can potentially overcome adherence issues and complications in wound healing applications. |
| first_indexed | 2024-03-10T03:19:16Z |
| format | Article |
| id | doaj.art-40cec1509e814401ac8af4bfe5ecf4dd |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T03:19:16Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-40cec1509e814401ac8af4bfe5ecf4dd2023-11-23T10:05:54ZengMDPI AGPharmaceutics1999-49232021-12-011312210010.3390/pharmaceutics13122100Topical Chitosan-Based Thermo-Responsive Scaffold Provides Dexketoprofen Trometamol Controlled Release for 24 h UseLuis Castillo-Henríquez0Pablo Sanabria-Espinoza1Brayan Murillo-Castillo2Gabriela Montes de Oca-Vásquez3Diego Batista-Menezes4Briner Calvo-Guzmán5Nils Ramírez-Arguedas6José Vega-Baudrit7National Laboratory of Nanotechnology (LANOTEC), National Center for High Technology (CeNAT), San José 1174-1200, Costa RicaLaboratory of Physical Chemistry, Faculty of Pharmacy, University of Costa Rica, San José 11501-2060, Costa RicaLaboratory of Physical Chemistry, Faculty of Pharmacy, University of Costa Rica, San José 11501-2060, Costa RicaNational Laboratory of Nanotechnology (LANOTEC), National Center for High Technology (CeNAT), San José 1174-1200, Costa RicaNational Laboratory of Nanotechnology (LANOTEC), National Center for High Technology (CeNAT), San José 1174-1200, Costa RicaLaboratorios Infarma LTDA, Cartago 30801, Costa RicaLaboratory of Physical Chemistry, Faculty of Pharmacy, University of Costa Rica, San José 11501-2060, Costa RicaNational Laboratory of Nanotechnology (LANOTEC), National Center for High Technology (CeNAT), San José 1174-1200, Costa RicaChronic and non-healing wounds demand personalized and more effective therapies for treating complications and improving patient compliance. Concerning that, this work aims to develop a suitable chitosan-based thermo-responsive scaffold to provide 24 h controlled release of Dexketoprofen trometamol (DKT). Three formulation prototypes were developed using chitosan (F1), 2:1 chitosan: PVA (F2), and 1:1 chitosan:gelatin (F3). Compatibility tests were done by DSC, TG, and FT-IR. SEM was employed to examine the morphology of the surface and inner layers from the scaffolds. In vitro release studies were performed at 32 °C and 38 °C, and the profiles were later adjusted to different kinetic models for the best formulation. F3 showed the most controlled release of DKT at 32 °C for 24 h (77.75 ± 2.72%) and reduced the burst release in the initial 6 h (40.18 ± 1.00%). The formulation exhibited a lower critical solution temperature (LCST) at 34.96 °C, and due to this phase transition, an increased release was observed at 38 °C (88.52 ± 2.07% at 12 h). The release profile for this formulation fits with Hixson–Crowell and Korsmeyer–Peppas kinetic models at both temperatures. Therefore, the developed scaffold for DKT delivery performs adequate controlled release, thereby; it can potentially overcome adherence issues and complications in wound healing applications.https://www.mdpi.com/1999-4923/13/12/2100chitosandexketoprofen trometamoldrug deliverygelatinNSAIDspersonalized medicine |
| spellingShingle | Luis Castillo-Henríquez Pablo Sanabria-Espinoza Brayan Murillo-Castillo Gabriela Montes de Oca-Vásquez Diego Batista-Menezes Briner Calvo-Guzmán Nils Ramírez-Arguedas José Vega-Baudrit Topical Chitosan-Based Thermo-Responsive Scaffold Provides Dexketoprofen Trometamol Controlled Release for 24 h Use Pharmaceutics chitosan dexketoprofen trometamol drug delivery gelatin NSAIDs personalized medicine |
| title | Topical Chitosan-Based Thermo-Responsive Scaffold Provides Dexketoprofen Trometamol Controlled Release for 24 h Use |
| title_full | Topical Chitosan-Based Thermo-Responsive Scaffold Provides Dexketoprofen Trometamol Controlled Release for 24 h Use |
| title_fullStr | Topical Chitosan-Based Thermo-Responsive Scaffold Provides Dexketoprofen Trometamol Controlled Release for 24 h Use |
| title_full_unstemmed | Topical Chitosan-Based Thermo-Responsive Scaffold Provides Dexketoprofen Trometamol Controlled Release for 24 h Use |
| title_short | Topical Chitosan-Based Thermo-Responsive Scaffold Provides Dexketoprofen Trometamol Controlled Release for 24 h Use |
| title_sort | topical chitosan based thermo responsive scaffold provides dexketoprofen trometamol controlled release for 24 h use |
| topic | chitosan dexketoprofen trometamol drug delivery gelatin NSAIDs personalized medicine |
| url | https://www.mdpi.com/1999-4923/13/12/2100 |
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