Inter-relationship of Histone Deacetylase-6 with Tau-cytoskeletal organization and remodeling
Cytoskeletal elements are the key players in cellular integrity, structure, signalling and migration. Each cytoskeletal element comprises of properties with respect to its structure and stability, which serve a specific array of functions. These structures are highly dynamic and regulated by modulat...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | European Journal of Cell Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S017193352200005X |
| _version_ | 1818248812298240000 |
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| author | Abhishek Ankur Balmik Subashchandrabose Chinnathambi |
| author_facet | Abhishek Ankur Balmik Subashchandrabose Chinnathambi |
| author_sort | Abhishek Ankur Balmik |
| collection | DOAJ |
| description | Cytoskeletal elements are the key players in cellular integrity, structure, signalling and migration. Each cytoskeletal element comprises of properties with respect to its structure and stability, which serve a specific array of functions. These structures are highly dynamic and regulated by modulation via direct interaction or post-translational modifications. HDAC6 is a cytoplasmic deacetylase known to regulate a wide range of cellular functions either through its deacetylase activity or direct interaction via its C-terminal ZnF UBP domain. HDAC6 has been widely studied for its role in aggresome formation, which acts as a protective mechanism upon protein aggregation. HDAC6 is known to play a critical role in the regulation of cytoskeletal elements-microtubules and actin filaments. This review summarizes the regulatory role of HDAC6 in cytoskeletal remodeling and dynamics of neuronal cells and its significance in neurodegenerative diseases. |
| first_indexed | 2024-12-12T15:26:33Z |
| format | Article |
| id | doaj.art-40ceef0d6f7342a09a27c47e4e36d7ae |
| institution | Directory Open Access Journal |
| issn | 0171-9335 |
| language | English |
| last_indexed | 2024-12-12T15:26:33Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Cell Biology |
| spelling | doaj.art-40ceef0d6f7342a09a27c47e4e36d7ae2022-12-22T00:20:14ZengElsevierEuropean Journal of Cell Biology0171-93352022-04-011012151202Inter-relationship of Histone Deacetylase-6 with Tau-cytoskeletal organization and remodelingAbhishek Ankur Balmik0Subashchandrabose Chinnathambi1Neurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, 411008 Pune, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, IndiaNeurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, 411008 Pune, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; Correspondence to: Neurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, 411008 Pune, India.Cytoskeletal elements are the key players in cellular integrity, structure, signalling and migration. Each cytoskeletal element comprises of properties with respect to its structure and stability, which serve a specific array of functions. These structures are highly dynamic and regulated by modulation via direct interaction or post-translational modifications. HDAC6 is a cytoplasmic deacetylase known to regulate a wide range of cellular functions either through its deacetylase activity or direct interaction via its C-terminal ZnF UBP domain. HDAC6 has been widely studied for its role in aggresome formation, which acts as a protective mechanism upon protein aggregation. HDAC6 is known to play a critical role in the regulation of cytoskeletal elements-microtubules and actin filaments. This review summarizes the regulatory role of HDAC6 in cytoskeletal remodeling and dynamics of neuronal cells and its significance in neurodegenerative diseases.http://www.sciencedirect.com/science/article/pii/S017193352200005XHDAC6ZnF UBPActinMicrotubulesCell migrationCytoskeleton remodeling |
| spellingShingle | Abhishek Ankur Balmik Subashchandrabose Chinnathambi Inter-relationship of Histone Deacetylase-6 with Tau-cytoskeletal organization and remodeling European Journal of Cell Biology HDAC6 ZnF UBP Actin Microtubules Cell migration Cytoskeleton remodeling |
| title | Inter-relationship of Histone Deacetylase-6 with Tau-cytoskeletal organization and remodeling |
| title_full | Inter-relationship of Histone Deacetylase-6 with Tau-cytoskeletal organization and remodeling |
| title_fullStr | Inter-relationship of Histone Deacetylase-6 with Tau-cytoskeletal organization and remodeling |
| title_full_unstemmed | Inter-relationship of Histone Deacetylase-6 with Tau-cytoskeletal organization and remodeling |
| title_short | Inter-relationship of Histone Deacetylase-6 with Tau-cytoskeletal organization and remodeling |
| title_sort | inter relationship of histone deacetylase 6 with tau cytoskeletal organization and remodeling |
| topic | HDAC6 ZnF UBP Actin Microtubules Cell migration Cytoskeleton remodeling |
| url | http://www.sciencedirect.com/science/article/pii/S017193352200005X |
| work_keys_str_mv | AT abhishekankurbalmik interrelationshipofhistonedeacetylase6withtaucytoskeletalorganizationandremodeling AT subashchandrabosechinnathambi interrelationshipofhistonedeacetylase6withtaucytoskeletalorganizationandremodeling |