Cancer Associated Fibroblasts: Naughty Neighbors That Drive Ovarian Cancer Progression
Ovarian cancer is the most lethal gynecologic malignancy, and patient prognosis has not improved significantly over the last several decades. In order to improve therapeutic approaches and patient outcomes, there is a critical need for focused research towards better understanding of the disease. Re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-10-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/10/11/406 |
| _version_ | 1797713136332046336 |
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| author | Subramanyam Dasari Yiming Fang Anirban K. Mitra |
| author_facet | Subramanyam Dasari Yiming Fang Anirban K. Mitra |
| author_sort | Subramanyam Dasari |
| collection | DOAJ |
| description | Ovarian cancer is the most lethal gynecologic malignancy, and patient prognosis has not improved significantly over the last several decades. In order to improve therapeutic approaches and patient outcomes, there is a critical need for focused research towards better understanding of the disease. Recent findings have revealed that the tumor microenvironment plays an essential role in promoting cancer progression and metastasis. The tumor microenvironment consists of cancer cells and several different types of normal cells recruited and reprogrammed by the cancer cells to produce factors beneficial to tumor growth and spread. These normal cells present within the tumor, along with the various extracellular matrix proteins and secreted factors, constitute the tumor stroma and can compose 10⁻60% of the tumor volume. Cancer associated fibroblasts (CAFs) are a major constituent of the tumor microenvironment, and play a critical role in promoting many aspects of tumor function. This review will describe the various hypotheses about the origin of CAFs, their major functions in the tumor microenvironment in ovarian cancer, and will discuss the potential of targeting CAFs as a possible therapeutic approach. |
| first_indexed | 2024-03-12T07:31:54Z |
| format | Article |
| id | doaj.art-40d2bf19adae40f7891a0b6bad8b481c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T07:31:54Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-40d2bf19adae40f7891a0b6bad8b481c2023-09-02T21:45:02ZengMDPI AGCancers2072-66942018-10-01101140610.3390/cancers10110406cancers10110406Cancer Associated Fibroblasts: Naughty Neighbors That Drive Ovarian Cancer ProgressionSubramanyam Dasari0Yiming Fang1Anirban K. Mitra2Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN 47401, USAMedical Sciences Program, Indiana University School of Medicine, Bloomington, IN 47401, USAMedical Sciences Program, Indiana University School of Medicine, Bloomington, IN 47401, USAOvarian cancer is the most lethal gynecologic malignancy, and patient prognosis has not improved significantly over the last several decades. In order to improve therapeutic approaches and patient outcomes, there is a critical need for focused research towards better understanding of the disease. Recent findings have revealed that the tumor microenvironment plays an essential role in promoting cancer progression and metastasis. The tumor microenvironment consists of cancer cells and several different types of normal cells recruited and reprogrammed by the cancer cells to produce factors beneficial to tumor growth and spread. These normal cells present within the tumor, along with the various extracellular matrix proteins and secreted factors, constitute the tumor stroma and can compose 10⁻60% of the tumor volume. Cancer associated fibroblasts (CAFs) are a major constituent of the tumor microenvironment, and play a critical role in promoting many aspects of tumor function. This review will describe the various hypotheses about the origin of CAFs, their major functions in the tumor microenvironment in ovarian cancer, and will discuss the potential of targeting CAFs as a possible therapeutic approach.https://www.mdpi.com/2072-6694/10/11/406ovarian cancertumor microenvironmentcancer associated fibroblastsfibroblastcross-talkinvasionangiogenesisECMchemoresistancetherapy |
| spellingShingle | Subramanyam Dasari Yiming Fang Anirban K. Mitra Cancer Associated Fibroblasts: Naughty Neighbors That Drive Ovarian Cancer Progression Cancers ovarian cancer tumor microenvironment cancer associated fibroblasts fibroblast cross-talk invasion angiogenesis ECM chemoresistance therapy |
| title | Cancer Associated Fibroblasts: Naughty Neighbors That Drive Ovarian Cancer Progression |
| title_full | Cancer Associated Fibroblasts: Naughty Neighbors That Drive Ovarian Cancer Progression |
| title_fullStr | Cancer Associated Fibroblasts: Naughty Neighbors That Drive Ovarian Cancer Progression |
| title_full_unstemmed | Cancer Associated Fibroblasts: Naughty Neighbors That Drive Ovarian Cancer Progression |
| title_short | Cancer Associated Fibroblasts: Naughty Neighbors That Drive Ovarian Cancer Progression |
| title_sort | cancer associated fibroblasts naughty neighbors that drive ovarian cancer progression |
| topic | ovarian cancer tumor microenvironment cancer associated fibroblasts fibroblast cross-talk invasion angiogenesis ECM chemoresistance therapy |
| url | https://www.mdpi.com/2072-6694/10/11/406 |
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