Sirtuin 1 and Sirtuin 2 Plasma Concentrations in Patients with Ascending Aortic Dissection and Ascending Aortic Aneurysm
Abstract Background Previous studies explored multifactorial interactions and sirtuin expression in the aortic cells of laboratory rodents and humans. Human studies were limited due to the availability of biological material exclusively in the advanced stage of the disease. The role of sirtuins in a...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Artery Research |
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| Online Access: | https://doi.org/10.1007/s44200-023-00035-3 |
| _version_ | 1797689110407675904 |
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| author | Jan Krekora Oliwia Matuszewska-Brycht Julia Sołek Wojciech Fendler Jolanta Fryczak Piotr Stępiński Michał Krejca Agnieszka Siejka Arkadiusz Retwiński Piotr Merks Daria Kaczmarek Jarosław Drożdż |
| author_facet | Jan Krekora Oliwia Matuszewska-Brycht Julia Sołek Wojciech Fendler Jolanta Fryczak Piotr Stępiński Michał Krejca Agnieszka Siejka Arkadiusz Retwiński Piotr Merks Daria Kaczmarek Jarosław Drożdż |
| author_sort | Jan Krekora |
| collection | DOAJ |
| description | Abstract Background Previous studies explored multifactorial interactions and sirtuin expression in the aortic cells of laboratory rodents and humans. Human studies were limited due to the availability of biological material exclusively in the advanced stage of the disease. The role of sirtuins in aortic pathology has not been explained extensively therefore the aim of the study was to assess the plasma concentrations of human sirtuin 1 (SIRT1) and human sirtuin 2 (SIRT2) in patients with ascending aortic dissection and ascending aortic aneurysm. Material and methods The study group included 43 adults (34 males and 9 females) aged 44–92 years with ascending aortic dissection (n = 10) or with ascending aortic aneurysm (n = 33). The SIRT1 and SIRT2 plasma concentrations in patients’ blood samples were determined, and the differences between groups were observed (p = 0.02 for SIRT1, p = 0.04 for SIRT2). Results Levels of both SIRT1 and SIRT2 were lower in patients with ascending aortic dissection (SIRT1: median = 6.5 ng/mL; SIRT2: median = 5.7 ng/mL) than in patients with ascending aortic aneurysm (SIRT1: median = 9.2 ng/mL; SIRT2: median = 7.8 ng/mL). The SIRT1 and SIRT2 cut-off levels differentiating both groups of patients were 6.7 ng/mL and 3.2 ng/mL, respectively. Conclusions The patients with ascending aortic dissection had lower plasma concentrations of SIRT1 and SIRT2 than the patients with ascending aortic aneurysm. Calculated cut-off values for both enzymes may be helpful in laboratory differentiation of ascending aortic dissection from ascending aortic aneurysm. |
| first_indexed | 2024-03-12T01:41:18Z |
| format | Article |
| id | doaj.art-40d40c5800f4427a87e184b952b09069 |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-03-12T01:41:18Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-40d40c5800f4427a87e184b952b090692023-09-10T11:09:15ZengBMCArtery Research1876-44012023-06-01293798210.1007/s44200-023-00035-3Sirtuin 1 and Sirtuin 2 Plasma Concentrations in Patients with Ascending Aortic Dissection and Ascending Aortic AneurysmJan Krekora0Oliwia Matuszewska-Brycht1Julia Sołek2Wojciech Fendler3Jolanta Fryczak4Piotr Stępiński5Michał Krejca6Agnieszka Siejka7Arkadiusz Retwiński8Piotr Merks9Daria Kaczmarek10Jarosław Drożdż11Chair of Cardiology, Cardiac Surgery, and Vascular Diseases, II Department of Cardiology, Medical University of LodzChair of Cardiology, Cardiac Surgery, and Vascular Diseases, II Department of Cardiology, Medical University of LodzDepartment of Biostatistics and Translational Medicine, Medical University of LodzDepartment of Biostatistics and Translational Medicine, Medical University of LodzChair of Endocrinology, Department of Immunoendocrinology, Medical University of LodzChair of Cardiology, Cardiac Surgery, and Vascular Diseases, Department of Cardiac Surgery, Medical University of LodzChair of Cardiology, Cardiac Surgery, and Vascular Diseases, Department of Cardiac Surgery, Medical University of LodzChair of Endocrinology, Department of Endocrinology, Medical University of LodzChair of Cardiology, Cardiac Surgery, and Vascular Diseases, II Department of Cardiology, Medical University of LodzDepartment of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University in WarsawChair of Cardiology, Cardiac Surgery, and Vascular Diseases, II Department of Cardiology, Medical University of LodzChair of Cardiology, Cardiac Surgery, and Vascular Diseases, II Department of Cardiology, Medical University of LodzAbstract Background Previous studies explored multifactorial interactions and sirtuin expression in the aortic cells of laboratory rodents and humans. Human studies were limited due to the availability of biological material exclusively in the advanced stage of the disease. The role of sirtuins in aortic pathology has not been explained extensively therefore the aim of the study was to assess the plasma concentrations of human sirtuin 1 (SIRT1) and human sirtuin 2 (SIRT2) in patients with ascending aortic dissection and ascending aortic aneurysm. Material and methods The study group included 43 adults (34 males and 9 females) aged 44–92 years with ascending aortic dissection (n = 10) or with ascending aortic aneurysm (n = 33). The SIRT1 and SIRT2 plasma concentrations in patients’ blood samples were determined, and the differences between groups were observed (p = 0.02 for SIRT1, p = 0.04 for SIRT2). Results Levels of both SIRT1 and SIRT2 were lower in patients with ascending aortic dissection (SIRT1: median = 6.5 ng/mL; SIRT2: median = 5.7 ng/mL) than in patients with ascending aortic aneurysm (SIRT1: median = 9.2 ng/mL; SIRT2: median = 7.8 ng/mL). The SIRT1 and SIRT2 cut-off levels differentiating both groups of patients were 6.7 ng/mL and 3.2 ng/mL, respectively. Conclusions The patients with ascending aortic dissection had lower plasma concentrations of SIRT1 and SIRT2 than the patients with ascending aortic aneurysm. Calculated cut-off values for both enzymes may be helpful in laboratory differentiation of ascending aortic dissection from ascending aortic aneurysm.https://doi.org/10.1007/s44200-023-00035-3Aortic aneurysmAortic dissectionAortic pathologySirtuin 1Sirtuin 2 |
| spellingShingle | Jan Krekora Oliwia Matuszewska-Brycht Julia Sołek Wojciech Fendler Jolanta Fryczak Piotr Stępiński Michał Krejca Agnieszka Siejka Arkadiusz Retwiński Piotr Merks Daria Kaczmarek Jarosław Drożdż Sirtuin 1 and Sirtuin 2 Plasma Concentrations in Patients with Ascending Aortic Dissection and Ascending Aortic Aneurysm Artery Research Aortic aneurysm Aortic dissection Aortic pathology Sirtuin 1 Sirtuin 2 |
| title | Sirtuin 1 and Sirtuin 2 Plasma Concentrations in Patients with Ascending Aortic Dissection and Ascending Aortic Aneurysm |
| title_full | Sirtuin 1 and Sirtuin 2 Plasma Concentrations in Patients with Ascending Aortic Dissection and Ascending Aortic Aneurysm |
| title_fullStr | Sirtuin 1 and Sirtuin 2 Plasma Concentrations in Patients with Ascending Aortic Dissection and Ascending Aortic Aneurysm |
| title_full_unstemmed | Sirtuin 1 and Sirtuin 2 Plasma Concentrations in Patients with Ascending Aortic Dissection and Ascending Aortic Aneurysm |
| title_short | Sirtuin 1 and Sirtuin 2 Plasma Concentrations in Patients with Ascending Aortic Dissection and Ascending Aortic Aneurysm |
| title_sort | sirtuin 1 and sirtuin 2 plasma concentrations in patients with ascending aortic dissection and ascending aortic aneurysm |
| topic | Aortic aneurysm Aortic dissection Aortic pathology Sirtuin 1 Sirtuin 2 |
| url | https://doi.org/10.1007/s44200-023-00035-3 |
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