Clinical and histopathological characteristics, diagnosis and treatment, and comorbidities of Bowen’s disease: a retrospective study
BackgroundBowen’s disease (BD) is a slow-growing precancerous skin condition, often concurrent with other diseases, with a high misdiagnosis rate. Previous studies show that patients with BD in different populations have differentiated characteristics.Materials and methodsA retrospective study was c...
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1281540/full |
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| author | Cheng Zhou Cheng Zhou Bin Jiang Bin Jiang Kaoyuan Zhang Kaoyuan Zhang Jingwen Wu Jingwen Wu Cong Huang Cong Huang Ning Xu Ning Xu Tinglu Ye Tinglu Ye Bancheng Chen Bancheng Chen Bo Yu Bo Yu Yanfen Zou Yanfen Zou Changbing Shen Changbing Shen |
| author_facet | Cheng Zhou Cheng Zhou Bin Jiang Bin Jiang Kaoyuan Zhang Kaoyuan Zhang Jingwen Wu Jingwen Wu Cong Huang Cong Huang Ning Xu Ning Xu Tinglu Ye Tinglu Ye Bancheng Chen Bancheng Chen Bo Yu Bo Yu Yanfen Zou Yanfen Zou Changbing Shen Changbing Shen |
| author_sort | Cheng Zhou |
| collection | DOAJ |
| description | BackgroundBowen’s disease (BD) is a slow-growing precancerous skin condition, often concurrent with other diseases, with a high misdiagnosis rate. Previous studies show that patients with BD in different populations have differentiated characteristics.Materials and methodsA retrospective study was conducted in a tertiary hospital in Shenzhen, China. Data about demographic information, diagnosis and treatment, clinical and pathological characteristics, and comorbidities of 50 patients with BD were collected and analyzed.ResultsClinical data of onset age and disease course of 43 patients with BD were available, the average onset age of male and female patients are 55.1 (standard deviation (SD) = 15.29) and 58.2 (SD = 15.59) years old, respectively; the average disease course of male and female patients are 25.3 (SD = 28.63) and 33.9 (SD = 49.65) months, respectively. The onset age (p = 0.52) and disease course (p = 0.49) between male and female patients are not significantly different. Interestingly, there is a negative correlation between onset age and disease course (r = −0.245, p = 0.11). The correct rate of clinical diagnosis is relatively low (54.00%); Some patients with BD are misdiagnosed as Bowenoid papulosis (10.00%), actinic keratosis (8.00%), basal cell carcinoma (8.00%), seborrheic keratosis (6.00%), and pigmented naevus (4.00%). Trunk and limbs are the most common distribution sites of BD lesions, and 94.00% patients with BD are treated with surgical resection; 66.00% patients with BD had comorbidities, including skin diseases (48.48%), cardiovascular diseases (39.39%), gastrointestinal diseases (30.30%), respiratory diseases (27.27%), and tumors (18.18%). The most commonly observed histopathological characteristics of BD are squamous-cell hyperplasia (86.00%), disordered maturation with atypical keratinocytes (74.00%), atypical mitoses (60.00%), hyperkeratosis with hypokeratosis (48.00%), dermal inflammatory cell infiltration (36.00%), and koilocytosis (22.00%).ConclusionBD often occurs in middle-aged and elderly people and is easily misdiagnosed. The onset age and disease course of patients with BD are not significantly different between males and females, whereas there is a negative correlation between the onset age and disease course. BD is more likely to occur in trunk and limbs in the Chinese population, and most patients with BD are concurrent with comorbidities. |
| first_indexed | 2024-03-11T07:05:24Z |
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| last_indexed | 2024-03-11T07:05:24Z |
| publishDate | 2023-11-01 |
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| spelling | doaj.art-40d40ce1a3c947c3a00a3937221ec6582023-11-17T08:56:14ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-11-011010.3389/fmed.2023.12815401281540Clinical and histopathological characteristics, diagnosis and treatment, and comorbidities of Bowen’s disease: a retrospective studyCheng Zhou0Cheng Zhou1Bin Jiang2Bin Jiang3Kaoyuan Zhang4Kaoyuan Zhang5Jingwen Wu6Jingwen Wu7Cong Huang8Cong Huang9Ning Xu10Ning Xu11Tinglu Ye12Tinglu Ye13Bancheng Chen14Bancheng Chen15Bo Yu16Bo Yu17Yanfen Zou18Yanfen Zou19Changbing Shen20Changbing Shen21Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Institute of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, ChinaDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Institute of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, ChinaDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Institute of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, ChinaDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Institute of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, ChinaDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Institute of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, ChinaDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Institute of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, ChinaDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Institute of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, ChinaDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Institute of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, ChinaDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Institute of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, ChinaDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Institute of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, ChinaDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory for Translational Medicine of Dermatology, Institute of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, ChinaBackgroundBowen’s disease (BD) is a slow-growing precancerous skin condition, often concurrent with other diseases, with a high misdiagnosis rate. Previous studies show that patients with BD in different populations have differentiated characteristics.Materials and methodsA retrospective study was conducted in a tertiary hospital in Shenzhen, China. Data about demographic information, diagnosis and treatment, clinical and pathological characteristics, and comorbidities of 50 patients with BD were collected and analyzed.ResultsClinical data of onset age and disease course of 43 patients with BD were available, the average onset age of male and female patients are 55.1 (standard deviation (SD) = 15.29) and 58.2 (SD = 15.59) years old, respectively; the average disease course of male and female patients are 25.3 (SD = 28.63) and 33.9 (SD = 49.65) months, respectively. The onset age (p = 0.52) and disease course (p = 0.49) between male and female patients are not significantly different. Interestingly, there is a negative correlation between onset age and disease course (r = −0.245, p = 0.11). The correct rate of clinical diagnosis is relatively low (54.00%); Some patients with BD are misdiagnosed as Bowenoid papulosis (10.00%), actinic keratosis (8.00%), basal cell carcinoma (8.00%), seborrheic keratosis (6.00%), and pigmented naevus (4.00%). Trunk and limbs are the most common distribution sites of BD lesions, and 94.00% patients with BD are treated with surgical resection; 66.00% patients with BD had comorbidities, including skin diseases (48.48%), cardiovascular diseases (39.39%), gastrointestinal diseases (30.30%), respiratory diseases (27.27%), and tumors (18.18%). The most commonly observed histopathological characteristics of BD are squamous-cell hyperplasia (86.00%), disordered maturation with atypical keratinocytes (74.00%), atypical mitoses (60.00%), hyperkeratosis with hypokeratosis (48.00%), dermal inflammatory cell infiltration (36.00%), and koilocytosis (22.00%).ConclusionBD often occurs in middle-aged and elderly people and is easily misdiagnosed. The onset age and disease course of patients with BD are not significantly different between males and females, whereas there is a negative correlation between the onset age and disease course. BD is more likely to occur in trunk and limbs in the Chinese population, and most patients with BD are concurrent with comorbidities.https://www.frontiersin.org/articles/10.3389/fmed.2023.1281540/fullBowen’s diseasecharacteristicdiagnosistreatmentcomorbidityretrospective study |
| spellingShingle | Cheng Zhou Cheng Zhou Bin Jiang Bin Jiang Kaoyuan Zhang Kaoyuan Zhang Jingwen Wu Jingwen Wu Cong Huang Cong Huang Ning Xu Ning Xu Tinglu Ye Tinglu Ye Bancheng Chen Bancheng Chen Bo Yu Bo Yu Yanfen Zou Yanfen Zou Changbing Shen Changbing Shen Clinical and histopathological characteristics, diagnosis and treatment, and comorbidities of Bowen’s disease: a retrospective study Frontiers in Medicine Bowen’s disease characteristic diagnosis treatment comorbidity retrospective study |
| title | Clinical and histopathological characteristics, diagnosis and treatment, and comorbidities of Bowen’s disease: a retrospective study |
| title_full | Clinical and histopathological characteristics, diagnosis and treatment, and comorbidities of Bowen’s disease: a retrospective study |
| title_fullStr | Clinical and histopathological characteristics, diagnosis and treatment, and comorbidities of Bowen’s disease: a retrospective study |
| title_full_unstemmed | Clinical and histopathological characteristics, diagnosis and treatment, and comorbidities of Bowen’s disease: a retrospective study |
| title_short | Clinical and histopathological characteristics, diagnosis and treatment, and comorbidities of Bowen’s disease: a retrospective study |
| title_sort | clinical and histopathological characteristics diagnosis and treatment and comorbidities of bowen s disease a retrospective study |
| topic | Bowen’s disease characteristic diagnosis treatment comorbidity retrospective study |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1281540/full |
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