Sick Sinus Syndrome After a Single Oral Administration of Garenoxacin
This report presents the case of a 60-year-old female who demonstrated sick sinus syndrome after a single administration of Garenoxacin (GRNX). She was administered GRNX for an upper respiratory infection and 10 minutes thereafter, she suddenly felt palpitation and numbness of both arms. She was tra...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Journal of Arrhythmia |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1880427610800389 |
| _version_ | 1818960952932958208 |
|---|---|
| author | Chiyo Sugiyama, MD Yoshinobu Kojima, MD Yasumasa Hashimoto, MD Kentaro Morishita, MD Hironobu Sato, MD Hirokazu Kumada, MD Norihiko Morita, MD |
| author_facet | Chiyo Sugiyama, MD Yoshinobu Kojima, MD Yasumasa Hashimoto, MD Kentaro Morishita, MD Hironobu Sato, MD Hirokazu Kumada, MD Norihiko Morita, MD |
| author_sort | Chiyo Sugiyama, MD |
| collection | DOAJ |
| description | This report presents the case of a 60-year-old female who demonstrated sick sinus syndrome after a single administration of Garenoxacin (GRNX). She was administered GRNX for an upper respiratory infection and 10 minutes thereafter, she suddenly felt palpitation and numbness of both arms. She was transferred to the hospital 2 hours after taking GRNX. An electrocardiogram showed bradycardia with junctional escape beats and the longest sinus arrest was 4 seconds. She was treated with a temporary pacemaker and 21 hours after the administration of GRNX her sinus node function was observed to have completely improved. GRNX-induced sick sinus syndrome was suspected because her clinical course was compatible with the concentration of GRNX and her other cardiological assessments, including an electrophysiologic study (EPS) which were conducted on the 9th day of the admission, were normal. GRNX has less effect on the QT interval than other quinolone agents. However, physicians should be aware of the risk of sick sinus syndrome because GRNX is frequently prescribed in outpatient clinics. |
| first_indexed | 2024-12-20T12:05:43Z |
| format | Article |
| id | doaj.art-40d5bf49639743208f2709060e491238 |
| institution | Directory Open Access Journal |
| issn | 1880-4276 |
| language | English |
| last_indexed | 2024-12-20T12:05:43Z |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Arrhythmia |
| spelling | doaj.art-40d5bf49639743208f2709060e4912382022-12-21T19:41:23ZengWileyJournal of Arrhythmia1880-42762010-01-01261626610.1016/S1880-4276(10)80038-9Sick Sinus Syndrome After a Single Oral Administration of GarenoxacinChiyo Sugiyama, MDYoshinobu Kojima, MDYasumasa Hashimoto, MDKentaro Morishita, MDHironobu Sato, MDHirokazu Kumada, MDNorihiko Morita, MDThis report presents the case of a 60-year-old female who demonstrated sick sinus syndrome after a single administration of Garenoxacin (GRNX). She was administered GRNX for an upper respiratory infection and 10 minutes thereafter, she suddenly felt palpitation and numbness of both arms. She was transferred to the hospital 2 hours after taking GRNX. An electrocardiogram showed bradycardia with junctional escape beats and the longest sinus arrest was 4 seconds. She was treated with a temporary pacemaker and 21 hours after the administration of GRNX her sinus node function was observed to have completely improved. GRNX-induced sick sinus syndrome was suspected because her clinical course was compatible with the concentration of GRNX and her other cardiological assessments, including an electrophysiologic study (EPS) which were conducted on the 9th day of the admission, were normal. GRNX has less effect on the QT interval than other quinolone agents. However, physicians should be aware of the risk of sick sinus syndrome because GRNX is frequently prescribed in outpatient clinics.http://www.sciencedirect.com/science/article/pii/S1880427610800389GarenoxacinSick sinus syndromeSinus pauseTransientDrug |
| spellingShingle | Chiyo Sugiyama, MD Yoshinobu Kojima, MD Yasumasa Hashimoto, MD Kentaro Morishita, MD Hironobu Sato, MD Hirokazu Kumada, MD Norihiko Morita, MD Sick Sinus Syndrome After a Single Oral Administration of Garenoxacin Journal of Arrhythmia Garenoxacin Sick sinus syndrome Sinus pause Transient Drug |
| title | Sick Sinus Syndrome After a Single Oral Administration of Garenoxacin |
| title_full | Sick Sinus Syndrome After a Single Oral Administration of Garenoxacin |
| title_fullStr | Sick Sinus Syndrome After a Single Oral Administration of Garenoxacin |
| title_full_unstemmed | Sick Sinus Syndrome After a Single Oral Administration of Garenoxacin |
| title_short | Sick Sinus Syndrome After a Single Oral Administration of Garenoxacin |
| title_sort | sick sinus syndrome after a single oral administration of garenoxacin |
| topic | Garenoxacin Sick sinus syndrome Sinus pause Transient Drug |
| url | http://www.sciencedirect.com/science/article/pii/S1880427610800389 |
| work_keys_str_mv | AT chiyosugiyamamd sicksinussyndromeafterasingleoraladministrationofgarenoxacin AT yoshinobukojimamd sicksinussyndromeafterasingleoraladministrationofgarenoxacin AT yasumasahashimotomd sicksinussyndromeafterasingleoraladministrationofgarenoxacin AT kentaromorishitamd sicksinussyndromeafterasingleoraladministrationofgarenoxacin AT hironobusatomd sicksinussyndromeafterasingleoraladministrationofgarenoxacin AT hirokazukumadamd sicksinussyndromeafterasingleoraladministrationofgarenoxacin AT norihikomoritamd sicksinussyndromeafterasingleoraladministrationofgarenoxacin |