Single-cell RNA sequencing reveals recruitment of the M2-like CCL8high macrophages in Lewis lung carcinoma-bearing mice following hypofractionated radiotherapy

Single-cell RNA sequencing reveals recruitment of the M2-like CCL8high macrophages in Lewis lung carcinoma-bearing mice following hypofractionated radiotherapy

Abstract Background Tumor-associated macrophages (TAMs) play a pivotal role in reshaping the tumor microenvironment following radiotherapy. The mechanisms underlying this reprogramming process remain to be elucidated. Methods Subcutaneous Lewis lung carcinoma (LLC) murine model was treated with hypo...

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Bibliographic Details
Main Authors: Haonan Yang, Zheng Lei, Jiang He, Lu Zhang, Tangmin Lai, Liu Zhou, Nuohan Wang, Zheng Tang, Jiangdong Sui, Yongzhong Wu
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Translational Medicine
Subjects:
Hypofractionated radiotherapy
Macrophages
Chemokines
CCL8
CCL signaling pathway
Online Access:https://doi.org/10.1186/s12967-024-05118-6

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