Bronchopulmonary Dysplasia in Extremely Premature Infants: A Scoping Review for Identifying Risk Factors
Background: Over the years, bronchopulmonary dysplasia (BPD) affects the pulmonary function of infants, resulting in chronic health burdens for infants and their families. The aim of this scoping review was to screen available evidence regarding perinatal risk factors associated with the development...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/2/553 |
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| author | Masato Ito Shin Kato Makoto Saito Naoyuki Miyahara Hirokazu Arai Fumihiko Namba Erika Ota Hidehiko Nakanishi |
| author_facet | Masato Ito Shin Kato Makoto Saito Naoyuki Miyahara Hirokazu Arai Fumihiko Namba Erika Ota Hidehiko Nakanishi |
| author_sort | Masato Ito |
| collection | DOAJ |
| description | Background: Over the years, bronchopulmonary dysplasia (BPD) affects the pulmonary function of infants, resulting in chronic health burdens for infants and their families. The aim of this scoping review was to screen available evidence regarding perinatal risk factors associated with the development and severity of BPD. Methods: The eligibility criteria of the studies were year of publication between 2016 and 2021; setting of a developed country; English or Japanese as the study language; and randomized controlled, cohort, or case-control design. The titles and abstracts of the studies were screened by independent reviewers. Results: Of 8189 eligible studies, 3 were included for severe BPD and 26 were included for moderate BPD. The risk factors for severe BPD were male sex, iatrogenic preterm birth, maternal hypertensive disorders of pregnancy (HDP), low gestational age, small-for-gestational-age (SGA) birth weight, mechanical ventilation on day 1, and need for patent ductus arteriosus (PDA) management. The risk factors for moderate or severe BPD included male sex, premature rupture of membranes, clinical chorioamnionitis, maternal HDP, SGA birth weight, bubbly/cystic appearance on X-ray, and PDA management. Conclusions: We identified several risk factors for BPD. We plan to confirm the validity of the new classification using the existing dataset. |
| first_indexed | 2024-03-11T09:06:47Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T09:06:47Z |
| publishDate | 2023-02-01 |
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| series | Biomedicines |
| spelling | doaj.art-40d5f6b641794d659d7ae7166bad99fb2023-11-16T19:19:56ZengMDPI AGBiomedicines2227-90592023-02-0111255310.3390/biomedicines11020553Bronchopulmonary Dysplasia in Extremely Premature Infants: A Scoping Review for Identifying Risk FactorsMasato Ito0Shin Kato1Makoto Saito2Naoyuki Miyahara3Hirokazu Arai4Fumihiko Namba5Erika Ota6Hidehiko Nakanishi7Department of Pediatrics, Akita University Graduate School of Medicine, Akita 010-8543, JapanDepartment of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8602, JapanDepartment of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8546, JapanDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe 350-8550, JapanDepartment of Neonatology, Akita Red Cross Hospital, Akita 010-1495, JapanDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe 350-8550, JapanGlobal Health Nursing, Graduate School of Nursing Sciences, St. Luke’s International University, Chuo 104-0044, JapanResearch and Development Center for New Medical Frontiers, Department of Advanced Medicine, Division of Neonatal Intensive Care Medicine, Kitasato University School of Medicine, Sagamihara 252-0375, JapanBackground: Over the years, bronchopulmonary dysplasia (BPD) affects the pulmonary function of infants, resulting in chronic health burdens for infants and their families. The aim of this scoping review was to screen available evidence regarding perinatal risk factors associated with the development and severity of BPD. Methods: The eligibility criteria of the studies were year of publication between 2016 and 2021; setting of a developed country; English or Japanese as the study language; and randomized controlled, cohort, or case-control design. The titles and abstracts of the studies were screened by independent reviewers. Results: Of 8189 eligible studies, 3 were included for severe BPD and 26 were included for moderate BPD. The risk factors for severe BPD were male sex, iatrogenic preterm birth, maternal hypertensive disorders of pregnancy (HDP), low gestational age, small-for-gestational-age (SGA) birth weight, mechanical ventilation on day 1, and need for patent ductus arteriosus (PDA) management. The risk factors for moderate or severe BPD included male sex, premature rupture of membranes, clinical chorioamnionitis, maternal HDP, SGA birth weight, bubbly/cystic appearance on X-ray, and PDA management. Conclusions: We identified several risk factors for BPD. We plan to confirm the validity of the new classification using the existing dataset.https://www.mdpi.com/2227-9059/11/2/553bronchopulmonary dysplasiascoping reviewprematureneonates |
| spellingShingle | Masato Ito Shin Kato Makoto Saito Naoyuki Miyahara Hirokazu Arai Fumihiko Namba Erika Ota Hidehiko Nakanishi Bronchopulmonary Dysplasia in Extremely Premature Infants: A Scoping Review for Identifying Risk Factors Biomedicines bronchopulmonary dysplasia scoping review premature neonates |
| title | Bronchopulmonary Dysplasia in Extremely Premature Infants: A Scoping Review for Identifying Risk Factors |
| title_full | Bronchopulmonary Dysplasia in Extremely Premature Infants: A Scoping Review for Identifying Risk Factors |
| title_fullStr | Bronchopulmonary Dysplasia in Extremely Premature Infants: A Scoping Review for Identifying Risk Factors |
| title_full_unstemmed | Bronchopulmonary Dysplasia in Extremely Premature Infants: A Scoping Review for Identifying Risk Factors |
| title_short | Bronchopulmonary Dysplasia in Extremely Premature Infants: A Scoping Review for Identifying Risk Factors |
| title_sort | bronchopulmonary dysplasia in extremely premature infants a scoping review for identifying risk factors |
| topic | bronchopulmonary dysplasia scoping review premature neonates |
| url | https://www.mdpi.com/2227-9059/11/2/553 |
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