Cardiac Autonomic Modulation Is Different in Terms of Clinical Variant of Multiple Sclerosis
This study evaluates whether the cardiac autonomic response to head-up tilt test (HUTT) differs between patients with relapsing-remitting multiple sclerosis (RRMS) and those with progressive MS (PMS) as compared to healthy controls (HC). Baroreflex sensitivity, cardiac parameters, heart rate (HRV) a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/10/3176 |
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| author | Monika Zawadka-Kunikowska Łukasz Rzepiński Julia L. Newton Paweł Zalewski Joanna Słomko |
| author_facet | Monika Zawadka-Kunikowska Łukasz Rzepiński Julia L. Newton Paweł Zalewski Joanna Słomko |
| author_sort | Monika Zawadka-Kunikowska |
| collection | DOAJ |
| description | This study evaluates whether the cardiac autonomic response to head-up tilt test (HUTT) differs between patients with relapsing-remitting multiple sclerosis (RRMS) and those with progressive MS (PMS) as compared to healthy controls (HC). Baroreflex sensitivity, cardiac parameters, heart rate (HRV) and blood pressure variability (BPV) were compared between 28 RRMS, 21PMS and 25 HC during HUTT. At rest, PMS patients had higher values of the sympathovagal ratio, a low-frequency band HRV (LFnu-RRI) and lower values of parasympathetic parameters (HFnu-RRI, HF-RRI) compared to RRMS and HC. Resting values of cardiac parameters were significantly lower in RRMS compared to PMS patients. No intergroup differences were observed for post-tilt cardiac and autonomic parameters, except for delta HF-RRI with lower values in the PMS group. The MS variant corrected for age, sex and Expanded Disability Status Scale (EDSS) score was an independent predictor of changes in the sympathovagal ratio as measured by HRV. Furthermore, a higher overall EDDS score was related to a higher sympathovagal ratio, lower parasympathetic parameters at rest, and decrease post-tilt changes of the sympathovagal ratio of sBP BPV. Autonomic imbalance is markedly altered in the MS patient group compared to control changes were most pronounced in the progressive variant of MS disease. The MS variant appeared to have a potential influence on cardiac autonomic imbalance at rest. |
| first_indexed | 2024-03-10T15:55:44Z |
| format | Article |
| id | doaj.art-40d839e2f03e41838901db82ba77b5e4 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T15:55:44Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-40d839e2f03e41838901db82ba77b5e42023-11-20T15:40:56ZengMDPI AGJournal of Clinical Medicine2077-03832020-09-01910317610.3390/jcm9103176Cardiac Autonomic Modulation Is Different in Terms of Clinical Variant of Multiple SclerosisMonika Zawadka-Kunikowska0Łukasz Rzepiński1Julia L. Newton2Paweł Zalewski3Joanna Słomko4Department of Hygiene, Epidemiology, Ergonomy and Postgraduate Education, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun, M. Sklodowskiej-Curie 9, 85-094 Bydgoszcz, PolandDepartment of Neurology, 10th Military Research Hospital and Polyclinic, 85-681 Bydgoszcz, PolandPopulation Health Science Institute, The Medical School, Newcastle University, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UKDepartment of Hygiene, Epidemiology, Ergonomy and Postgraduate Education, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun, M. Sklodowskiej-Curie 9, 85-094 Bydgoszcz, PolandDepartment of Hygiene, Epidemiology, Ergonomy and Postgraduate Education, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun, M. Sklodowskiej-Curie 9, 85-094 Bydgoszcz, PolandThis study evaluates whether the cardiac autonomic response to head-up tilt test (HUTT) differs between patients with relapsing-remitting multiple sclerosis (RRMS) and those with progressive MS (PMS) as compared to healthy controls (HC). Baroreflex sensitivity, cardiac parameters, heart rate (HRV) and blood pressure variability (BPV) were compared between 28 RRMS, 21PMS and 25 HC during HUTT. At rest, PMS patients had higher values of the sympathovagal ratio, a low-frequency band HRV (LFnu-RRI) and lower values of parasympathetic parameters (HFnu-RRI, HF-RRI) compared to RRMS and HC. Resting values of cardiac parameters were significantly lower in RRMS compared to PMS patients. No intergroup differences were observed for post-tilt cardiac and autonomic parameters, except for delta HF-RRI with lower values in the PMS group. The MS variant corrected for age, sex and Expanded Disability Status Scale (EDSS) score was an independent predictor of changes in the sympathovagal ratio as measured by HRV. Furthermore, a higher overall EDDS score was related to a higher sympathovagal ratio, lower parasympathetic parameters at rest, and decrease post-tilt changes of the sympathovagal ratio of sBP BPV. Autonomic imbalance is markedly altered in the MS patient group compared to control changes were most pronounced in the progressive variant of MS disease. The MS variant appeared to have a potential influence on cardiac autonomic imbalance at rest.https://www.mdpi.com/2077-0383/9/10/3176multiple sclerosisclinical variantheart rate variabilityblood pressure variabilitysympathovagal ratiocardiac autonomic imbalance |
| spellingShingle | Monika Zawadka-Kunikowska Łukasz Rzepiński Julia L. Newton Paweł Zalewski Joanna Słomko Cardiac Autonomic Modulation Is Different in Terms of Clinical Variant of Multiple Sclerosis Journal of Clinical Medicine multiple sclerosis clinical variant heart rate variability blood pressure variability sympathovagal ratio cardiac autonomic imbalance |
| title | Cardiac Autonomic Modulation Is Different in Terms of Clinical Variant of Multiple Sclerosis |
| title_full | Cardiac Autonomic Modulation Is Different in Terms of Clinical Variant of Multiple Sclerosis |
| title_fullStr | Cardiac Autonomic Modulation Is Different in Terms of Clinical Variant of Multiple Sclerosis |
| title_full_unstemmed | Cardiac Autonomic Modulation Is Different in Terms of Clinical Variant of Multiple Sclerosis |
| title_short | Cardiac Autonomic Modulation Is Different in Terms of Clinical Variant of Multiple Sclerosis |
| title_sort | cardiac autonomic modulation is different in terms of clinical variant of multiple sclerosis |
| topic | multiple sclerosis clinical variant heart rate variability blood pressure variability sympathovagal ratio cardiac autonomic imbalance |
| url | https://www.mdpi.com/2077-0383/9/10/3176 |
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