IGF Signaling in Intervertebral Disc Health and Disease
Low back pain (LBP) is a common musculoskeletal symptom, which brings a lot of pain and economic loss to patients. One of the most common causes of LBP is intervertebral disc degeneration (IVDD). However, pathogenesis is still debated, and therapeutic options are limited. Insulin-like growth factor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.817099/full |
| _version_ | 1819280527385952256 |
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| author | Hui Lin Shuo Tian Yizhong Peng Ling Wu Yan Xiao Xiangcheng Qing Zengwu Shao |
| author_facet | Hui Lin Shuo Tian Yizhong Peng Ling Wu Yan Xiao Xiangcheng Qing Zengwu Shao |
| author_sort | Hui Lin |
| collection | DOAJ |
| description | Low back pain (LBP) is a common musculoskeletal symptom, which brings a lot of pain and economic loss to patients. One of the most common causes of LBP is intervertebral disc degeneration (IVDD). However, pathogenesis is still debated, and therapeutic options are limited. Insulin-like growth factor (IGF) signaling pathways play an important role in regulating different cell processes, including proliferation, differentiation, migration, or cell death, which are critical to the homeostasis of tissues and organs. The IGF signaling is crucial in the occurrence and progression of IVDD. The activation of IGF signaling retards IVDD by increasing cell proliferation, promoting extracellular matrix (ECM) synthesis, inhibiting ECM decomposition, and preventing apoptosis and senescence of disc cells. However, abnormal activation of IGF signaling may promote the process of IVDD. IGF signaling is currently considered to have a promising treatment prospect for IVDD. An in-depth understanding of the role of IGF signaling in IVDD may help find a novel approach for IVDD treatment. |
| first_indexed | 2024-12-24T00:45:13Z |
| format | Article |
| id | doaj.art-40dbe3505b744d119793839fd614b3df |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-24T00:45:13Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-40dbe3505b744d119793839fd614b3df2022-12-21T17:23:50ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-02-01910.3389/fcell.2021.817099817099IGF Signaling in Intervertebral Disc Health and DiseaseHui Lin0Shuo Tian1Yizhong Peng2Ling Wu3Yan Xiao4Xiangcheng Qing5Zengwu Shao6Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaLow back pain (LBP) is a common musculoskeletal symptom, which brings a lot of pain and economic loss to patients. One of the most common causes of LBP is intervertebral disc degeneration (IVDD). However, pathogenesis is still debated, and therapeutic options are limited. Insulin-like growth factor (IGF) signaling pathways play an important role in regulating different cell processes, including proliferation, differentiation, migration, or cell death, which are critical to the homeostasis of tissues and organs. The IGF signaling is crucial in the occurrence and progression of IVDD. The activation of IGF signaling retards IVDD by increasing cell proliferation, promoting extracellular matrix (ECM) synthesis, inhibiting ECM decomposition, and preventing apoptosis and senescence of disc cells. However, abnormal activation of IGF signaling may promote the process of IVDD. IGF signaling is currently considered to have a promising treatment prospect for IVDD. An in-depth understanding of the role of IGF signaling in IVDD may help find a novel approach for IVDD treatment.https://www.frontiersin.org/articles/10.3389/fcell.2021.817099/fullinsulin-like growth factorintervertebral discnucleus pulposusdegenerationlow back pain |
| spellingShingle | Hui Lin Shuo Tian Yizhong Peng Ling Wu Yan Xiao Xiangcheng Qing Zengwu Shao IGF Signaling in Intervertebral Disc Health and Disease Frontiers in Cell and Developmental Biology insulin-like growth factor intervertebral disc nucleus pulposus degeneration low back pain |
| title | IGF Signaling in Intervertebral Disc Health and Disease |
| title_full | IGF Signaling in Intervertebral Disc Health and Disease |
| title_fullStr | IGF Signaling in Intervertebral Disc Health and Disease |
| title_full_unstemmed | IGF Signaling in Intervertebral Disc Health and Disease |
| title_short | IGF Signaling in Intervertebral Disc Health and Disease |
| title_sort | igf signaling in intervertebral disc health and disease |
| topic | insulin-like growth factor intervertebral disc nucleus pulposus degeneration low back pain |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.817099/full |
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