Gastrointestinal symptoms associated with gastroesophageal reflux disease, and their relapses after treatment with proton pump inhibitors: A systematic review
Gastroesophageal reflux disease (GERD) is a common functional gastrointestinal disorder with significant effects on the quality of life. The burden of GERD is soaring in Asia. Preventing symptom relapse is a therapeutic goal in GERD patients. Since proton pump inhibitors (PPI) are the first-line t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Electronic Physician
2017-06-01
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| Series: | Electronic Physician |
| Subjects: | |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557141/ |
| _version_ | 1811228827252162560 |
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| author | Mousalreza Hosseini Roshanak Salari Somayeh Shariatmaghani Batul Birjandi, Masoumeh Salari |
| author_facet | Mousalreza Hosseini Roshanak Salari Somayeh Shariatmaghani Batul Birjandi, Masoumeh Salari |
| author_sort | Mousalreza Hosseini |
| collection | DOAJ |
| description | Gastroesophageal reflux disease (GERD) is a common functional gastrointestinal disorder with significant effects
on the quality of life. The burden of GERD is soaring in Asia. Preventing symptom relapse is a therapeutic goal
in GERD patients. Since proton pump inhibitors (PPI) are the first-line treatment of GERD, drug failure has
become a major problem in the treatment procedure. We reviewed the literature in order to find articles related to
comorbidities and symptoms affecting GERD from 1980 to 2015 via PubMed and Google Scholar using
keywords such as ‘Gastroesophageal reflux disease’, ‘Gastrointestinal symptoms’ and Boolean operators (such as
AND, OR, NOT). Due to the cost of PPI therapy and the high rate of GERD relapse after PPI therapy, demand
for continuing this type of treatment is decreasing. Thus, we need to discover new approaches to treat the disease
and also investigate the relationship between the treatment of GERD and its comorbidities and symptoms such as
functional constipation. |
| first_indexed | 2024-04-12T10:02:52Z |
| format | Article |
| id | doaj.art-40de4e8ea1044de8a0af49a0e7177b8e |
| institution | Directory Open Access Journal |
| issn | 2008-5842 2008-5842 |
| language | English |
| last_indexed | 2024-04-12T10:02:52Z |
| publishDate | 2017-06-01 |
| publisher | Electronic Physician |
| record_format | Article |
| series | Electronic Physician |
| spelling | doaj.art-40de4e8ea1044de8a0af49a0e7177b8e2022-12-22T03:37:30ZengElectronic PhysicianElectronic Physician2008-58422008-58422017-06-01964597460510.19082/4597Gastrointestinal symptoms associated with gastroesophageal reflux disease, and their relapses after treatment with proton pump inhibitors: A systematic reviewMousalreza HosseiniRoshanak Salari Somayeh ShariatmaghaniBatul Birjandi,Masoumeh SalariGastroesophageal reflux disease (GERD) is a common functional gastrointestinal disorder with significant effects on the quality of life. The burden of GERD is soaring in Asia. Preventing symptom relapse is a therapeutic goal in GERD patients. Since proton pump inhibitors (PPI) are the first-line treatment of GERD, drug failure has become a major problem in the treatment procedure. We reviewed the literature in order to find articles related to comorbidities and symptoms affecting GERD from 1980 to 2015 via PubMed and Google Scholar using keywords such as ‘Gastroesophageal reflux disease’, ‘Gastrointestinal symptoms’ and Boolean operators (such as AND, OR, NOT). Due to the cost of PPI therapy and the high rate of GERD relapse after PPI therapy, demand for continuing this type of treatment is decreasing. Thus, we need to discover new approaches to treat the disease and also investigate the relationship between the treatment of GERD and its comorbidities and symptoms such as functional constipation.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557141/Gastroesophageal reflux disease (GERD)Proton pump inhibitors (PPI)Comorbidities |
| spellingShingle | Mousalreza Hosseini Roshanak Salari Somayeh Shariatmaghani Batul Birjandi, Masoumeh Salari Gastrointestinal symptoms associated with gastroesophageal reflux disease, and their relapses after treatment with proton pump inhibitors: A systematic review Electronic Physician Gastroesophageal reflux disease (GERD) Proton pump inhibitors (PPI) Comorbidities |
| title | Gastrointestinal symptoms associated with gastroesophageal reflux disease, and their relapses after treatment with proton pump inhibitors: A systematic review |
| title_full | Gastrointestinal symptoms associated with gastroesophageal reflux disease, and their relapses after treatment with proton pump inhibitors: A systematic review |
| title_fullStr | Gastrointestinal symptoms associated with gastroesophageal reflux disease, and their relapses after treatment with proton pump inhibitors: A systematic review |
| title_full_unstemmed | Gastrointestinal symptoms associated with gastroesophageal reflux disease, and their relapses after treatment with proton pump inhibitors: A systematic review |
| title_short | Gastrointestinal symptoms associated with gastroesophageal reflux disease, and their relapses after treatment with proton pump inhibitors: A systematic review |
| title_sort | gastrointestinal symptoms associated with gastroesophageal reflux disease and their relapses after treatment with proton pump inhibitors a systematic review |
| topic | Gastroesophageal reflux disease (GERD) Proton pump inhibitors (PPI) Comorbidities |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557141/ |
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