Photoprotective nanoemulsions containing microbial carotenoids and buriti oil: Efficacy and safety study
Photoprotective nanoemulsions are able to attenuate skin damage from overexposure to the sun, thus avoiding the immediate effects caused by ultraviolet radiation. The global cosmetics market understands that there is a demand and greater acceptance by consumers for formulations containing natural pr...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-08-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535220302343 |
| _version_ | 1818211792992600064 |
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| author | Maria Cristina Pinheiro Pereira Reis Mansur Christian Campos Alane Beatriz Vermelho Jonas Nobrega Leonardo da Cunha Boldrini Luciene Balottin Claudia Lage Alexandre Soares Rosado Eduardo Ricci-Júnior Elisabete Pereira dos Santos |
| author_facet | Maria Cristina Pinheiro Pereira Reis Mansur Christian Campos Alane Beatriz Vermelho Jonas Nobrega Leonardo da Cunha Boldrini Luciene Balottin Claudia Lage Alexandre Soares Rosado Eduardo Ricci-Júnior Elisabete Pereira dos Santos |
| author_sort | Maria Cristina Pinheiro Pereira Reis Mansur |
| collection | DOAJ |
| description | Photoprotective nanoemulsions are able to attenuate skin damage from overexposure to the sun, thus avoiding the immediate effects caused by ultraviolet radiation. The global cosmetics market understands that there is a demand and greater acceptance by consumers for formulations containing natural products compatible with the skin. Consequently, there is an increasingly need to develop such products that are safe and effective. Furthermore, there is a growing interest in nanoemulsions (NE) in the pharmaceutical industry, due the versatility of incorporating lipophilic substances into cosmetic formulations. In the present work, oil-in-water photoprotective nanoemulsions containing microbial carotenoids, buriti oil and chemical filters were developed and characterized. The essential physical properties of the droplets, the transmission electronic microscopy (TEM), the sun protection factor (SPF) as well as the stability of the formulations were determined. In vitro phototoxicity was evaluated using Balb 3 T3 with relative cell viability estimated by Neutral Red Uptake, with the Photo Irritation Factor (PIF) and the Medium Photo Effect Factor (MPF) as the measurement parameters. Nanoemulsion 3 (NE3) showed spherical morphology with an average droplet size of 142.11 ± 0.92 nm and polydispersity index (PDI) of 0.198 ± 0.017. This nanoemulsion containing microbial carotenoids and buriti oil exhibited a SPF of 36 ± 1.5. Neutral Red Uptake revealed that the cells kept their viability even after irradiation and those nanoemulsions containing the microbial carotenoids and buriti oil were not phototoxic. The addition of microbial carotenoids and buriti oil in nanoemulsions was positive in increasing the mean SPF values compared to the control formulation. |
| first_indexed | 2024-12-12T05:38:08Z |
| format | Article |
| id | doaj.art-40e01df8f8b3473f98a2f0285d16184f |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-12T05:38:08Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-40e01df8f8b3473f98a2f0285d16184f2022-12-22T00:36:01ZengElsevierArabian Journal of Chemistry1878-53522020-08-0113867416752Photoprotective nanoemulsions containing microbial carotenoids and buriti oil: Efficacy and safety studyMaria Cristina Pinheiro Pereira Reis Mansur0Christian Campos1Alane Beatriz Vermelho2Jonas Nobrega3Leonardo da Cunha Boldrini4Luciene Balottin5Claudia Lage6Alexandre Soares Rosado7Eduardo Ricci-Júnior8Elisabete Pereira dos Santos9BIOINOVAR - Biocatalysis, Bioproducts and Bioenergy, Paulo de Góes Institute of Microbiology, Federal University of Rio de Janeiro, Brazil; LADEG- Galenic Development Laboratory, Faculty of Pharmacy, Federal University of Rio de Janeiro, Brazil; Correspondence author at: LADEG, Federal University of Rio de Janeiro, Brazil, Avenida Carlos Chagas Filho, 373, Centro de Ciências da Saúde – CCS, Cidade Universitária, Ilha do Fundão, CEP 21941-902, Brazil.LADEG- Galenic Development Laboratory, Faculty of Pharmacy, Federal University of Rio de Janeiro, BrazilBIOINOVAR - Biocatalysis, Bioproducts and Bioenergy, Paulo de Góes Institute of Microbiology, Federal University of Rio de Janeiro, BrazilBIOINOVAR - Biocatalysis, Bioproducts and Bioenergy, Paulo de Góes Institute of Microbiology, Federal University of Rio de Janeiro, BrazilLabio/Dimav/Inmetro – Laboratory of Tissue Bioengineering/Directorate of Metrology Applied to Life Sciences/National Institute of Metrology, Quality and Technology, Duque de Caxias, Rio de Janeiro, Brazil; Postgraduate Program in Translational Biomedicine – BIOTRANS – Unigranrio, Inmetro, Uezo, Rio de Janeiro, BrazilLabio/Dimav/Inmetro – Laboratory of Tissue Bioengineering/Directorate of Metrology Applied to Life Sciences/National Institute of Metrology, Quality and Technology, Duque de Caxias, Rio de Janeiro, BrazilLaRBio – Radiations and Biology Laboratory, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, BrazilLEMM - Laboratory of Microbial Molecular Ecology, Paulo de Góes Institute of Microbiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, BrazilLADEG- Galenic Development Laboratory, Faculty of Pharmacy, Federal University of Rio de Janeiro, BrazilLADEG- Galenic Development Laboratory, Faculty of Pharmacy, Federal University of Rio de Janeiro, BrazilPhotoprotective nanoemulsions are able to attenuate skin damage from overexposure to the sun, thus avoiding the immediate effects caused by ultraviolet radiation. The global cosmetics market understands that there is a demand and greater acceptance by consumers for formulations containing natural products compatible with the skin. Consequently, there is an increasingly need to develop such products that are safe and effective. Furthermore, there is a growing interest in nanoemulsions (NE) in the pharmaceutical industry, due the versatility of incorporating lipophilic substances into cosmetic formulations. In the present work, oil-in-water photoprotective nanoemulsions containing microbial carotenoids, buriti oil and chemical filters were developed and characterized. The essential physical properties of the droplets, the transmission electronic microscopy (TEM), the sun protection factor (SPF) as well as the stability of the formulations were determined. In vitro phototoxicity was evaluated using Balb 3 T3 with relative cell viability estimated by Neutral Red Uptake, with the Photo Irritation Factor (PIF) and the Medium Photo Effect Factor (MPF) as the measurement parameters. Nanoemulsion 3 (NE3) showed spherical morphology with an average droplet size of 142.11 ± 0.92 nm and polydispersity index (PDI) of 0.198 ± 0.017. This nanoemulsion containing microbial carotenoids and buriti oil exhibited a SPF of 36 ± 1.5. Neutral Red Uptake revealed that the cells kept their viability even after irradiation and those nanoemulsions containing the microbial carotenoids and buriti oil were not phototoxic. The addition of microbial carotenoids and buriti oil in nanoemulsions was positive in increasing the mean SPF values compared to the control formulation.http://www.sciencedirect.com/science/article/pii/S1878535220302343PhotoprotectionNanoemulsionsMicrobial-carotenoidsBuriti oilSPF |
| spellingShingle | Maria Cristina Pinheiro Pereira Reis Mansur Christian Campos Alane Beatriz Vermelho Jonas Nobrega Leonardo da Cunha Boldrini Luciene Balottin Claudia Lage Alexandre Soares Rosado Eduardo Ricci-Júnior Elisabete Pereira dos Santos Photoprotective nanoemulsions containing microbial carotenoids and buriti oil: Efficacy and safety study Arabian Journal of Chemistry Photoprotection Nanoemulsions Microbial-carotenoids Buriti oil SPF |
| title | Photoprotective nanoemulsions containing microbial carotenoids and buriti oil: Efficacy and safety study |
| title_full | Photoprotective nanoemulsions containing microbial carotenoids and buriti oil: Efficacy and safety study |
| title_fullStr | Photoprotective nanoemulsions containing microbial carotenoids and buriti oil: Efficacy and safety study |
| title_full_unstemmed | Photoprotective nanoemulsions containing microbial carotenoids and buriti oil: Efficacy and safety study |
| title_short | Photoprotective nanoemulsions containing microbial carotenoids and buriti oil: Efficacy and safety study |
| title_sort | photoprotective nanoemulsions containing microbial carotenoids and buriti oil efficacy and safety study |
| topic | Photoprotection Nanoemulsions Microbial-carotenoids Buriti oil SPF |
| url | http://www.sciencedirect.com/science/article/pii/S1878535220302343 |
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