Structure-guided design of a potent Clostridioides difficile toxin A inhibitor

Structure-guided design of a potent Clostridioides difficile toxin A inhibitor

Crystal structures of camelid heavy-chain antibody variable domains (VHHs) bound to fragments of the combined repetitive oligopeptides domain of Clostridioides difficile toxin A (TcdA) reveal that the C-terminus of VHH A20 was located 30 Å away from the N-terminus of VHH A26. Based on this observati...

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Bibliographic Details
Main Authors: Greg Hussack, Martin A. Rossotti, Henk van Faassen, Tomohiko Murase, Luiz Eugenio, Joseph D. Schrag, Kenneth K.-S. Ng, Jamshid Tanha
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Microbiology
Subjects:
biparatopic
Clostridioides difficile
inhibitor
nanobody
single-domain antibody
toxin
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1110541/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1110541/full

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