SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces.
Neurons store information by changing synaptic input weights. In addition, they can adjust their membrane excitability to alter spike output. Here, we demonstrate a role of such "intrinsic plasticity" in behavioral learning in a mouse model that allows us to detect specific consequences of...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3000596 |
| _version_ | 1818591864257773568 |
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| author | Giorgio Grasselli Henk-Jan Boele Heather K Titley Nora Bradford Lisa van Beers Lindsey Jay Gerco C Beekhof Silas E Busch Chris I De Zeeuw Martijn Schonewille Christian Hansel |
| author_facet | Giorgio Grasselli Henk-Jan Boele Heather K Titley Nora Bradford Lisa van Beers Lindsey Jay Gerco C Beekhof Silas E Busch Chris I De Zeeuw Martijn Schonewille Christian Hansel |
| author_sort | Giorgio Grasselli |
| collection | DOAJ |
| description | Neurons store information by changing synaptic input weights. In addition, they can adjust their membrane excitability to alter spike output. Here, we demonstrate a role of such "intrinsic plasticity" in behavioral learning in a mouse model that allows us to detect specific consequences of absent excitability modulation. Mice with a Purkinje-cell-specific knockout (KO) of the calcium-activated K+ channel SK2 (L7-SK2) show intact vestibulo-ocular reflex (VOR) gain adaptation but impaired eyeblink conditioning (EBC), which relies on the ability to establish associations between stimuli, with the eyelid closure itself depending on a transient suppression of spike firing. In these mice, the intrinsic plasticity of Purkinje cells is prevented without affecting long-term depression or potentiation at their parallel fiber (PF) input. In contrast to the typical spike pattern of EBC-supporting zebrin-negative Purkinje cells, L7-SK2 neurons show reduced background spiking but enhanced excitability. Thus, SK2 plasticity and excitability modulation are essential for specific forms of motor learning. |
| first_indexed | 2024-12-16T10:19:12Z |
| format | Article |
| id | doaj.art-40e48f6ef570448790263fe844f50d3b |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-16T10:19:12Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-40e48f6ef570448790263fe844f50d3b2022-12-21T22:35:21ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852020-01-01181e300059610.1371/journal.pbio.3000596SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces.Giorgio GrasselliHenk-Jan BoeleHeather K TitleyNora BradfordLisa van BeersLindsey JayGerco C BeekhofSilas E BuschChris I De ZeeuwMartijn SchonewilleChristian HanselNeurons store information by changing synaptic input weights. In addition, they can adjust their membrane excitability to alter spike output. Here, we demonstrate a role of such "intrinsic plasticity" in behavioral learning in a mouse model that allows us to detect specific consequences of absent excitability modulation. Mice with a Purkinje-cell-specific knockout (KO) of the calcium-activated K+ channel SK2 (L7-SK2) show intact vestibulo-ocular reflex (VOR) gain adaptation but impaired eyeblink conditioning (EBC), which relies on the ability to establish associations between stimuli, with the eyelid closure itself depending on a transient suppression of spike firing. In these mice, the intrinsic plasticity of Purkinje cells is prevented without affecting long-term depression or potentiation at their parallel fiber (PF) input. In contrast to the typical spike pattern of EBC-supporting zebrin-negative Purkinje cells, L7-SK2 neurons show reduced background spiking but enhanced excitability. Thus, SK2 plasticity and excitability modulation are essential for specific forms of motor learning.https://doi.org/10.1371/journal.pbio.3000596 |
| spellingShingle | Giorgio Grasselli Henk-Jan Boele Heather K Titley Nora Bradford Lisa van Beers Lindsey Jay Gerco C Beekhof Silas E Busch Chris I De Zeeuw Martijn Schonewille Christian Hansel SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces. PLoS Biology |
| title | SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces. |
| title_full | SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces. |
| title_fullStr | SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces. |
| title_full_unstemmed | SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces. |
| title_short | SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces. |
| title_sort | sk2 channels in cerebellar purkinje cells contribute to excitability modulation in motor learning specific memory traces |
| url | https://doi.org/10.1371/journal.pbio.3000596 |
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