Serum Myoglobin in Patients with Thyroid Dysfunction
Objectives: To assess the pattern of change in serum myoglobin concentration in subjects with thyroid dysfunction. Methods: Serum samples were selected from 150 subjects with suspected thyroid disorder who were referred to the Royal Hospital, Muscat, Oman. The subjects were 35 males and 115 females,...
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| Format: | Article |
| Language: | English |
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Sultan Qaboos University
2009-04-01
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| Series: | Sultan Qaboos University Medical Journal |
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| Online Access: | https://journals.squ.edu.om/index.php/squmj/article/view/1399 |
| _version_ | 1818163446691135488 |
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| author | Waad-Allah S Mula-Abed Sawsan S Al-Sinani Huda S Al-Hashmi |
| author_facet | Waad-Allah S Mula-Abed Sawsan S Al-Sinani Huda S Al-Hashmi |
| author_sort | Waad-Allah S Mula-Abed |
| collection | DOAJ |
| description | Objectives: To assess the pattern of change in serum myoglobin concentration in subjects with thyroid dysfunction. Methods: Serum samples were selected from 150 subjects with suspected thyroid disorder who were referred to the Royal Hospital, Muscat, Oman. The subjects were 35 males and 115 females, aged 14-56 years with mean ± SD of 34.3 ± 12.7 years. They were classified on the basis of thyroid stimulating hormone (TSH) and free thyroxine (FT4) into 3 groups, each consisting of 50 subjects: hypothyroid, hyperthyroid, and euthyroid subjects. Results: The mean serum myoglobin concentration was higher in hypothyroid patients compared to hyperthyroid and euthyroid subjects (mean ± SD was 38.5 ± 23.1 µg/L in hypothyroid; 18.1 ± 7.0µg/L in hyperthyroid; 17.4 ± 5.7µg/L in euthyroid). There was a significant difference in myoglobin concentration between hypothyroid and euthyroid groups (F = 36.1, p< 0.001), however, there was no significant difference between the hyperthyroid and euthyroid groups. When the mean ± 2SD for myoglobin in euthyroid subjects was calculated, the reference range was 6-29 µg/L. Of the hypothyroid subjects, 29 (58%) had high myoglobin and 21 (42%) had normal myoglobin level. No significant correlation was noticed between TSH or FT4 and myoglobin in all studied subjects. Conclusion:Raised serum myoglobin may be observed in patients with hypothyroidism. Hence hypothyroidism should be considered in the differential diagnosis of patients with raised serum myoglobin concentration. |
| first_indexed | 2024-12-11T16:49:42Z |
| format | Article |
| id | doaj.art-40e49820ebf84482a128fa5566941124 |
| institution | Directory Open Access Journal |
| issn | 2075-051X 2075-0528 |
| language | English |
| last_indexed | 2024-12-11T16:49:42Z |
| publishDate | 2009-04-01 |
| publisher | Sultan Qaboos University |
| record_format | Article |
| series | Sultan Qaboos University Medical Journal |
| spelling | doaj.art-40e49820ebf84482a128fa55669411242022-12-22T00:58:07ZengSultan Qaboos UniversitySultan Qaboos University Medical Journal2075-051X2075-05282009-04-019137411327Serum Myoglobin in Patients with Thyroid DysfunctionWaad-Allah S Mula-Abed0Sawsan S Al-Sinani1Huda S Al-Hashmi2Department of Chemical Pathology, Royal Hospital, Muscat, Sultanate of OmanDepartment of Chemical Pathology, Royal Hospital, Muscat, Sultanate of OmanDepartment of Chemical Pathology, Royal Hospital, Muscat, Sultanate of OmanObjectives: To assess the pattern of change in serum myoglobin concentration in subjects with thyroid dysfunction. Methods: Serum samples were selected from 150 subjects with suspected thyroid disorder who were referred to the Royal Hospital, Muscat, Oman. The subjects were 35 males and 115 females, aged 14-56 years with mean ± SD of 34.3 ± 12.7 years. They were classified on the basis of thyroid stimulating hormone (TSH) and free thyroxine (FT4) into 3 groups, each consisting of 50 subjects: hypothyroid, hyperthyroid, and euthyroid subjects. Results: The mean serum myoglobin concentration was higher in hypothyroid patients compared to hyperthyroid and euthyroid subjects (mean ± SD was 38.5 ± 23.1 µg/L in hypothyroid; 18.1 ± 7.0µg/L in hyperthyroid; 17.4 ± 5.7µg/L in euthyroid). There was a significant difference in myoglobin concentration between hypothyroid and euthyroid groups (F = 36.1, p< 0.001), however, there was no significant difference between the hyperthyroid and euthyroid groups. When the mean ± 2SD for myoglobin in euthyroid subjects was calculated, the reference range was 6-29 µg/L. Of the hypothyroid subjects, 29 (58%) had high myoglobin and 21 (42%) had normal myoglobin level. No significant correlation was noticed between TSH or FT4 and myoglobin in all studied subjects. Conclusion:Raised serum myoglobin may be observed in patients with hypothyroidism. Hence hypothyroidism should be considered in the differential diagnosis of patients with raised serum myoglobin concentration.https://journals.squ.edu.om/index.php/squmj/article/view/1399myoglobinhypothyroidism. |
| spellingShingle | Waad-Allah S Mula-Abed Sawsan S Al-Sinani Huda S Al-Hashmi Serum Myoglobin in Patients with Thyroid Dysfunction Sultan Qaboos University Medical Journal myoglobin hypothyroidism. |
| title | Serum Myoglobin in Patients with Thyroid Dysfunction |
| title_full | Serum Myoglobin in Patients with Thyroid Dysfunction |
| title_fullStr | Serum Myoglobin in Patients with Thyroid Dysfunction |
| title_full_unstemmed | Serum Myoglobin in Patients with Thyroid Dysfunction |
| title_short | Serum Myoglobin in Patients with Thyroid Dysfunction |
| title_sort | serum myoglobin in patients with thyroid dysfunction |
| topic | myoglobin hypothyroidism. |
| url | https://journals.squ.edu.om/index.php/squmj/article/view/1399 |
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