Increased Copper in Individuals with Autism Normalizes Post Zinc Therapy More Efficiently in Individuals with Concurrent GI Disease
Aim To assess plasma zinc and copper concentration in individuals with autism. Subjects and Methods Plasma from 79 autistic individuals, and 18 age and gender similar neurotypical controls, were tested for plasma zinc and copper using inductively-coupled plasma-mass spectrometry. Results Autistic in...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2011-01-01
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| Series: | Nutrition and Metabolic Insights |
| Online Access: | https://doi.org/10.4137/NMI.S6827 |
| _version_ | 1811313404819800064 |
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| author | Anthony J. Russo |
| author_facet | Anthony J. Russo |
| author_sort | Anthony J. Russo |
| collection | DOAJ |
| description | Aim To assess plasma zinc and copper concentration in individuals with autism. Subjects and Methods Plasma from 79 autistic individuals, and 18 age and gender similar neurotypical controls, were tested for plasma zinc and copper using inductively-coupled plasma-mass spectrometry. Results Autistic individuals had significantly elevated plasma levels of copper and Cu/Zn and lower, but not significantly lower, plasma Zn compared to neurotypical controls. Zn levels increased significantly in autistic individuals with and without GI disease after zinc therapy. Cu decreased significantly after zinc therapy in the GI disease group but not in the autistic group without GI disease. Autistic children significantly improved with respect to hyperactivity and stimming after zinc therapy in autistic children with GI disease. Autistic children without GI disease did not improve in these symptoms after the same therapy. Discussion These results suggest an association between zinc and copper plasma levels and autism, and they suggest that zinc therapy may be most effective at lowering copper levels in autistic children with GI disease. |
| first_indexed | 2024-04-13T10:53:12Z |
| format | Article |
| id | doaj.art-40e50e2574d7486bacee15bc8663ae30 |
| institution | Directory Open Access Journal |
| issn | 1178-6388 |
| language | English |
| last_indexed | 2024-04-13T10:53:12Z |
| publishDate | 2011-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Nutrition and Metabolic Insights |
| spelling | doaj.art-40e50e2574d7486bacee15bc8663ae302022-12-22T02:49:35ZengSAGE PublishingNutrition and Metabolic Insights1178-63882011-01-01410.4137/NMI.S6827Increased Copper in Individuals with Autism Normalizes Post Zinc Therapy More Efficiently in Individuals with Concurrent GI DiseaseAnthony J. Russo0Hartwick College, Oneonta, NY 13820. Health Research Institute/Pfeiffer Treatment Center 4575 Weaver Parkway Warrenville, Illinois 60555.Aim To assess plasma zinc and copper concentration in individuals with autism. Subjects and Methods Plasma from 79 autistic individuals, and 18 age and gender similar neurotypical controls, were tested for plasma zinc and copper using inductively-coupled plasma-mass spectrometry. Results Autistic individuals had significantly elevated plasma levels of copper and Cu/Zn and lower, but not significantly lower, plasma Zn compared to neurotypical controls. Zn levels increased significantly in autistic individuals with and without GI disease after zinc therapy. Cu decreased significantly after zinc therapy in the GI disease group but not in the autistic group without GI disease. Autistic children significantly improved with respect to hyperactivity and stimming after zinc therapy in autistic children with GI disease. Autistic children without GI disease did not improve in these symptoms after the same therapy. Discussion These results suggest an association between zinc and copper plasma levels and autism, and they suggest that zinc therapy may be most effective at lowering copper levels in autistic children with GI disease.https://doi.org/10.4137/NMI.S6827 |
| spellingShingle | Anthony J. Russo Increased Copper in Individuals with Autism Normalizes Post Zinc Therapy More Efficiently in Individuals with Concurrent GI Disease Nutrition and Metabolic Insights |
| title | Increased Copper in Individuals with Autism Normalizes Post Zinc Therapy More Efficiently in Individuals with Concurrent GI Disease |
| title_full | Increased Copper in Individuals with Autism Normalizes Post Zinc Therapy More Efficiently in Individuals with Concurrent GI Disease |
| title_fullStr | Increased Copper in Individuals with Autism Normalizes Post Zinc Therapy More Efficiently in Individuals with Concurrent GI Disease |
| title_full_unstemmed | Increased Copper in Individuals with Autism Normalizes Post Zinc Therapy More Efficiently in Individuals with Concurrent GI Disease |
| title_short | Increased Copper in Individuals with Autism Normalizes Post Zinc Therapy More Efficiently in Individuals with Concurrent GI Disease |
| title_sort | increased copper in individuals with autism normalizes post zinc therapy more efficiently in individuals with concurrent gi disease |
| url | https://doi.org/10.4137/NMI.S6827 |
| work_keys_str_mv | AT anthonyjrusso increasedcopperinindividualswithautismnormalizespostzinctherapymoreefficientlyinindividualswithconcurrentgidisease |