mRNA Vaccine Nanoplatforms and Innate Immunity
mRNA-based vaccine technology has been significantly developed and enhanced, particularly highlighted by the authorization of mRNA vaccines for addressing the COVID-19 pandemic. Various biomaterials are developed in nano-scales and applied as mRNA vaccine delivery platforms. However, how these mRNA...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/16/1/120 |
| _version_ | 1797342371508125696 |
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| author | Lai Wei Chunhong Dong Wandi Zhu Bao-Zhong Wang |
| author_facet | Lai Wei Chunhong Dong Wandi Zhu Bao-Zhong Wang |
| author_sort | Lai Wei |
| collection | DOAJ |
| description | mRNA-based vaccine technology has been significantly developed and enhanced, particularly highlighted by the authorization of mRNA vaccines for addressing the COVID-19 pandemic. Various biomaterials are developed in nano-scales and applied as mRNA vaccine delivery platforms. However, how these mRNA nanoplatforms influence immune responses has not been thoroughly studied. Hence, we have reviewed the current understanding of various mRNA vaccine platforms. We discussed the possible pathways through which these platforms moderate the host’s innate immunity and contribute to the development of adaptive immunity. We shed light on their development in reducing biotoxicity and enhancing antigen delivery efficiency. Beyond the built-in adjuvanticity of mRNA vaccines, we propose that supplementary adjuvants may be required to fine-tune and precisely control innate immunity and subsequent adaptive immune responses. |
| first_indexed | 2024-03-08T10:32:20Z |
| format | Article |
| id | doaj.art-40e591f61755413486da13e4db5986a6 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-08T10:32:20Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-40e591f61755413486da13e4db5986a62024-01-26T18:48:22ZengMDPI AGViruses1999-49152024-01-0116112010.3390/v16010120mRNA Vaccine Nanoplatforms and Innate ImmunityLai Wei0Chunhong Dong1Wandi Zhu2Bao-Zhong Wang3Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USACenter for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USACenter for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USACenter for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USAmRNA-based vaccine technology has been significantly developed and enhanced, particularly highlighted by the authorization of mRNA vaccines for addressing the COVID-19 pandemic. Various biomaterials are developed in nano-scales and applied as mRNA vaccine delivery platforms. However, how these mRNA nanoplatforms influence immune responses has not been thoroughly studied. Hence, we have reviewed the current understanding of various mRNA vaccine platforms. We discussed the possible pathways through which these platforms moderate the host’s innate immunity and contribute to the development of adaptive immunity. We shed light on their development in reducing biotoxicity and enhancing antigen delivery efficiency. Beyond the built-in adjuvanticity of mRNA vaccines, we propose that supplementary adjuvants may be required to fine-tune and precisely control innate immunity and subsequent adaptive immune responses.https://www.mdpi.com/1999-4915/16/1/120mRNA vaccineinnate immunitylipid nanoparticlespolymer nanoparticlesadjuvants |
| spellingShingle | Lai Wei Chunhong Dong Wandi Zhu Bao-Zhong Wang mRNA Vaccine Nanoplatforms and Innate Immunity Viruses mRNA vaccine innate immunity lipid nanoparticles polymer nanoparticles adjuvants |
| title | mRNA Vaccine Nanoplatforms and Innate Immunity |
| title_full | mRNA Vaccine Nanoplatforms and Innate Immunity |
| title_fullStr | mRNA Vaccine Nanoplatforms and Innate Immunity |
| title_full_unstemmed | mRNA Vaccine Nanoplatforms and Innate Immunity |
| title_short | mRNA Vaccine Nanoplatforms and Innate Immunity |
| title_sort | mrna vaccine nanoplatforms and innate immunity |
| topic | mRNA vaccine innate immunity lipid nanoparticles polymer nanoparticles adjuvants |
| url | https://www.mdpi.com/1999-4915/16/1/120 |
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