Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status
Cell competition causes the removal of less fit cells (‘losers’) but why some gene mutations turn cells into losers is unclear. Here, the authors show that Drosophila wing disc cells carrying some loser mutations activate Nrf2 and JNK signalling, which contribute to the loser status.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00145-y |
| _version_ | 1818851193430999040 |
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| author | Iwo Kucinski Michael Dinan Golnar Kolahgar Eugenia Piddini |
| author_facet | Iwo Kucinski Michael Dinan Golnar Kolahgar Eugenia Piddini |
| author_sort | Iwo Kucinski |
| collection | DOAJ |
| description | Cell competition causes the removal of less fit cells (‘losers’) but why some gene mutations turn cells into losers is unclear. Here, the authors show that Drosophila wing disc cells carrying some loser mutations activate Nrf2 and JNK signalling, which contribute to the loser status. |
| first_indexed | 2024-12-19T07:01:08Z |
| format | Article |
| id | doaj.art-40e708fdafc0405db4f51bc1e5a3c199 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T07:01:08Z |
| publishDate | 2017-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-40e708fdafc0405db4f51bc1e5a3c1992022-12-21T20:31:24ZengNature PortfolioNature Communications2041-17232017-07-018111310.1038/s41467-017-00145-yChronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell statusIwo Kucinski0Michael Dinan1Golnar Kolahgar2Eugenia Piddini3The Wellcome Trust/Cancer Research UK Gurdon Institute and Zoology Department, University of CambridgeThe Wellcome Trust/Cancer Research UK Gurdon Institute and Zoology Department, University of CambridgeThe Wellcome Trust/Cancer Research UK Gurdon Institute and Zoology Department, University of CambridgeThe Wellcome Trust/Cancer Research UK Gurdon Institute and Zoology Department, University of CambridgeCell competition causes the removal of less fit cells (‘losers’) but why some gene mutations turn cells into losers is unclear. Here, the authors show that Drosophila wing disc cells carrying some loser mutations activate Nrf2 and JNK signalling, which contribute to the loser status.https://doi.org/10.1038/s41467-017-00145-y |
| spellingShingle | Iwo Kucinski Michael Dinan Golnar Kolahgar Eugenia Piddini Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status Nature Communications |
| title | Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status |
| title_full | Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status |
| title_fullStr | Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status |
| title_full_unstemmed | Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status |
| title_short | Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status |
| title_sort | chronic activation of jnk jak stat and oxidative stress signalling causes the loser cell status |
| url | https://doi.org/10.1038/s41467-017-00145-y |
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