Resveratrol and liver: A systematic review
Background: Recent studies demonstrated that resveratrol has many therapeutic effects on liver disorders. Resveratrol significantly increased survival after liver transplantation, decreased fat deposition, necrosis, and apoptosis which induced by ischemia in Wistar rats. It provided liver protection...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-01-01
|
| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2015;volume=20;issue=8;spage=797;epage=810;aulast=Faghihzadeh |
| _version_ | 1818390580953088000 |
|---|---|
| author | Forouzan Faghihzadeh Azita Hekmatdoost Payman Adibi |
| author_facet | Forouzan Faghihzadeh Azita Hekmatdoost Payman Adibi |
| author_sort | Forouzan Faghihzadeh |
| collection | DOAJ |
| description | Background: Recent studies demonstrated that resveratrol has many therapeutic effects on liver disorders. Resveratrol significantly increased survival after liver transplantation, decreased fat deposition, necrosis, and apoptosis which induced by ischemia in Wistar rats. It provided liver protection against chemical, cholestatic, and alcohol injury. Resveratrol can improve glucose metabolism and lipid profile and decrease liver fibrosis and steatosis. Furthermore, it was able to alter hepatic cell fatty acid composition. According to extension of liver disease around the world and necessity of finding new threat, this review critically examines the current preclinical in vitro and in vivo studies on the preventive and therapeutic effects of resveratrol in liver disorders. Materials and Methods: A search in PubMed, Google Scholar, and Scopus was undertaken to identify relevant literature using search terms, including "liver," "hepatic," and "Resveratrol." Both in vivo and in vitro studies were included. No time limiting considered for this search. Results: A total of 76 articles were eligible for this review. In these articles, resveratrol shows antioxidative properties in different models of hepatitis resulting in reducing of hepatic fibrosis. Conclusion: Resveratrol could reduce hepatic steatosis through modulating the insulin resistance and lipid profile in animals. These high quality preclinical studies propose the potential therapeutic implication of resveratrol in liver disorders especially those with hepatic steatosis. Resveratrol can play a pivotal role in prevention and treatment of liver disorders by reducing hepatic fibrosis. |
| first_indexed | 2024-12-14T04:59:54Z |
| format | Article |
| id | doaj.art-40e7e0b08bc54ae782cbe4d88eea2c9a |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-14T04:59:54Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-40e7e0b08bc54ae782cbe4d88eea2c9a2022-12-21T23:16:16ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362015-01-0120879781010.4103/1735-1995.168405Resveratrol and liver: A systematic reviewForouzan FaghihzadehAzita HekmatdoostPayman AdibiBackground: Recent studies demonstrated that resveratrol has many therapeutic effects on liver disorders. Resveratrol significantly increased survival after liver transplantation, decreased fat deposition, necrosis, and apoptosis which induced by ischemia in Wistar rats. It provided liver protection against chemical, cholestatic, and alcohol injury. Resveratrol can improve glucose metabolism and lipid profile and decrease liver fibrosis and steatosis. Furthermore, it was able to alter hepatic cell fatty acid composition. According to extension of liver disease around the world and necessity of finding new threat, this review critically examines the current preclinical in vitro and in vivo studies on the preventive and therapeutic effects of resveratrol in liver disorders. Materials and Methods: A search in PubMed, Google Scholar, and Scopus was undertaken to identify relevant literature using search terms, including "liver," "hepatic," and "Resveratrol." Both in vivo and in vitro studies were included. No time limiting considered for this search. Results: A total of 76 articles were eligible for this review. In these articles, resveratrol shows antioxidative properties in different models of hepatitis resulting in reducing of hepatic fibrosis. Conclusion: Resveratrol could reduce hepatic steatosis through modulating the insulin resistance and lipid profile in animals. These high quality preclinical studies propose the potential therapeutic implication of resveratrol in liver disorders especially those with hepatic steatosis. Resveratrol can play a pivotal role in prevention and treatment of liver disorders by reducing hepatic fibrosis.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2015;volume=20;issue=8;spage=797;epage=810;aulast=FaghihzadehAntioxidantfibrosisliverliver dysfunctionliver disordersliver transplantationnonalcoholic fatty liverresveratrolsteatosis |
| spellingShingle | Forouzan Faghihzadeh Azita Hekmatdoost Payman Adibi Resveratrol and liver: A systematic review Journal of Research in Medical Sciences Antioxidant fibrosis liver liver dysfunction liver disorders liver transplantation nonalcoholic fatty liver resveratrol steatosis |
| title | Resveratrol and liver: A systematic review |
| title_full | Resveratrol and liver: A systematic review |
| title_fullStr | Resveratrol and liver: A systematic review |
| title_full_unstemmed | Resveratrol and liver: A systematic review |
| title_short | Resveratrol and liver: A systematic review |
| title_sort | resveratrol and liver a systematic review |
| topic | Antioxidant fibrosis liver liver dysfunction liver disorders liver transplantation nonalcoholic fatty liver resveratrol steatosis |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2015;volume=20;issue=8;spage=797;epage=810;aulast=Faghihzadeh |
| work_keys_str_mv | AT forouzanfaghihzadeh resveratrolandliverasystematicreview AT azitahekmatdoost resveratrolandliverasystematicreview AT paymanadibi resveratrolandliverasystematicreview |