Exhaled breath condensate to discriminate individuals with different smoking habits by GC–TOF/MS
Abstract Smoking is a crucial factor in respiratory diseases and lung inflammation, which are the reasons for high mortality worldwide. Despite the negative impact that tobacco consumption causes on health, few metabolomics studies have compared the composition of biofluids from smoker and non-smoke...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-01564-z |
| _version_ | 1818429515894882304 |
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| author | A. Peralbo-Molina M. Calderón-Santiago B. Jurado-Gámez M. D. Luque de Castro F. Priego-Capote |
| author_facet | A. Peralbo-Molina M. Calderón-Santiago B. Jurado-Gámez M. D. Luque de Castro F. Priego-Capote |
| author_sort | A. Peralbo-Molina |
| collection | DOAJ |
| description | Abstract Smoking is a crucial factor in respiratory diseases and lung inflammation, which are the reasons for high mortality worldwide. Despite the negative impact that tobacco consumption causes on health, few metabolomics studies have compared the composition of biofluids from smoker and non-smoker individuals. Exhaled breath condensate (EBC) is one of the biofluids less employed for clinical studies despite its non-invasive sampling and the foreseeable relationship between its composition and respiratory diseases. EBC was used in this research as clinical sample to compare three groups of individuals: current smokers (CS), former smokers (FS) and never smokers (NS). Special attention was paid to the cumulative consumption expressed as smoked pack-year. The levels of 12 metabolites found statistically significant among the three groups of individuals were discussed to find an explanation to their altered levels. Significant compounds included monoacylglycerol derivatives, terpenes and other compounds, the presence of which could be associated to the influence of smoking on the qualitative and quantitative composition of the microbiome. |
| first_indexed | 2024-12-14T15:18:45Z |
| format | Article |
| id | doaj.art-40e80756cc5042d68733ebb7dc61e035 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T15:18:45Z |
| publishDate | 2017-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-40e80756cc5042d68733ebb7dc61e0352022-12-21T22:56:14ZengNature PortfolioScientific Reports2045-23222017-05-017111310.1038/s41598-017-01564-zExhaled breath condensate to discriminate individuals with different smoking habits by GC–TOF/MSA. Peralbo-Molina0M. Calderón-Santiago1B. Jurado-Gámez2M. D. Luque de Castro3F. Priego-Capote4Department of Analytical Chemistry, Annex Marie Curie Building, Campus of Rabanales, University of CórdobaDepartment of Analytical Chemistry, Annex Marie Curie Building, Campus of Rabanales, University of CórdobaMaimónides Institute of Biomedical Research (IMIBIC), Reina Sofía Hospital, University of CórdobaDepartment of Analytical Chemistry, Annex Marie Curie Building, Campus of Rabanales, University of CórdobaDepartment of Analytical Chemistry, Annex Marie Curie Building, Campus of Rabanales, University of CórdobaAbstract Smoking is a crucial factor in respiratory diseases and lung inflammation, which are the reasons for high mortality worldwide. Despite the negative impact that tobacco consumption causes on health, few metabolomics studies have compared the composition of biofluids from smoker and non-smoker individuals. Exhaled breath condensate (EBC) is one of the biofluids less employed for clinical studies despite its non-invasive sampling and the foreseeable relationship between its composition and respiratory diseases. EBC was used in this research as clinical sample to compare three groups of individuals: current smokers (CS), former smokers (FS) and never smokers (NS). Special attention was paid to the cumulative consumption expressed as smoked pack-year. The levels of 12 metabolites found statistically significant among the three groups of individuals were discussed to find an explanation to their altered levels. Significant compounds included monoacylglycerol derivatives, terpenes and other compounds, the presence of which could be associated to the influence of smoking on the qualitative and quantitative composition of the microbiome.https://doi.org/10.1038/s41598-017-01564-z |
| spellingShingle | A. Peralbo-Molina M. Calderón-Santiago B. Jurado-Gámez M. D. Luque de Castro F. Priego-Capote Exhaled breath condensate to discriminate individuals with different smoking habits by GC–TOF/MS Scientific Reports |
| title | Exhaled breath condensate to discriminate individuals with different smoking habits by GC–TOF/MS |
| title_full | Exhaled breath condensate to discriminate individuals with different smoking habits by GC–TOF/MS |
| title_fullStr | Exhaled breath condensate to discriminate individuals with different smoking habits by GC–TOF/MS |
| title_full_unstemmed | Exhaled breath condensate to discriminate individuals with different smoking habits by GC–TOF/MS |
| title_short | Exhaled breath condensate to discriminate individuals with different smoking habits by GC–TOF/MS |
| title_sort | exhaled breath condensate to discriminate individuals with different smoking habits by gc tof ms |
| url | https://doi.org/10.1038/s41598-017-01564-z |
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