Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
This study presents gene expression responses of cultured brain cells to hundreds of chemicals found in the environment and in food. The authors identified chemicals that induce transcriptomic profiles that overlap those seen in human brains affected with autism, aging, and neurodegeneration.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11173 |
| _version_ | 1819122498457829376 |
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| author | Brandon L. Pearson Jeremy M. Simon Eric S. McCoy Gabriela Salazar Giulia Fragola Mark J. Zylka |
| author_facet | Brandon L. Pearson Jeremy M. Simon Eric S. McCoy Gabriela Salazar Giulia Fragola Mark J. Zylka |
| author_sort | Brandon L. Pearson |
| collection | DOAJ |
| description | This study presents gene expression responses of cultured brain cells to hundreds of chemicals found in the environment and in food. The authors identified chemicals that induce transcriptomic profiles that overlap those seen in human brains affected with autism, aging, and neurodegeneration. |
| first_indexed | 2024-12-22T06:53:25Z |
| format | Article |
| id | doaj.art-40eab20cb9c14472bd55674dbc22b4f9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T06:53:25Z |
| publishDate | 2016-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-40eab20cb9c14472bd55674dbc22b4f92022-12-21T18:35:03ZengNature PortfolioNature Communications2041-17232016-03-017111210.1038/ncomms11173Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegenerationBrandon L. Pearson0Jeremy M. Simon1Eric S. McCoy2Gabriela Salazar3Giulia Fragola4Mark J. Zylka5Department of Cell Biology and Physiology, UNC Neuroscience Center, University of North Carolina at Chapel HillDepartment of Cell Biology and Physiology, UNC Neuroscience Center, University of North Carolina at Chapel HillDepartment of Cell Biology and Physiology, UNC Neuroscience Center, University of North Carolina at Chapel HillDepartment of Cell Biology and Physiology, UNC Neuroscience Center, University of North Carolina at Chapel HillDepartment of Cell Biology and Physiology, UNC Neuroscience Center, University of North Carolina at Chapel HillDepartment of Cell Biology and Physiology, UNC Neuroscience Center, University of North Carolina at Chapel HillThis study presents gene expression responses of cultured brain cells to hundreds of chemicals found in the environment and in food. The authors identified chemicals that induce transcriptomic profiles that overlap those seen in human brains affected with autism, aging, and neurodegeneration.https://doi.org/10.1038/ncomms11173 |
| spellingShingle | Brandon L. Pearson Jeremy M. Simon Eric S. McCoy Gabriela Salazar Giulia Fragola Mark J. Zylka Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration Nature Communications |
| title | Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration |
| title_full | Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration |
| title_fullStr | Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration |
| title_full_unstemmed | Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration |
| title_short | Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration |
| title_sort | identification of chemicals that mimic transcriptional changes associated with autism brain aging and neurodegeneration |
| url | https://doi.org/10.1038/ncomms11173 |
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