Pulmonary Arteriovenous Pressure Gradient and Time-Averaged Mean Velocity of Small Pulmonary Arteries Can Serve as Sensitive Biomarkers in the Diagnosis of Pulmonary Arterial Hypertension: A Preclinical Study by 4D-Flow MRI
(1) Background: Pulmonary arterial hypertension (PAH) is a serious condition that is associated with many cardiopulmonary diseases. Invasive right heart catheterization (RHC) is currently the only method for the definitive diagnosis and follow-up of PAH. In this study, we sought a non-invasive hemod...
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MDPI AG
2021-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/1/58 |
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| author | Ali Nahardani Simon Leistikow Katja Grün Martin Krämer Karl-Heinz Herrmann Andrea Schrepper Christian Jung Sara Moradi Paul Christian Schulze Lars Linsen Jürgen R. Reichenbach Verena Hoerr Marcus Franz |
| author_facet | Ali Nahardani Simon Leistikow Katja Grün Martin Krämer Karl-Heinz Herrmann Andrea Schrepper Christian Jung Sara Moradi Paul Christian Schulze Lars Linsen Jürgen R. Reichenbach Verena Hoerr Marcus Franz |
| author_sort | Ali Nahardani |
| collection | DOAJ |
| description | (1) Background: Pulmonary arterial hypertension (PAH) is a serious condition that is associated with many cardiopulmonary diseases. Invasive right heart catheterization (RHC) is currently the only method for the definitive diagnosis and follow-up of PAH. In this study, we sought a non-invasive hemodynamic biomarker for the diagnosis of PAH. (2) Methods: We applied prospectively respiratory and cardiac gated 4D-flow MRI at a 9.4T preclinical scanner on three different groups of Sprague Dawley rats: baseline (<i>n</i> = 11), moderate PAH (<i>n</i> = 8), and severe PAH (<i>n</i> = 8). The pressure gradients as well as the velocity values were analyzed from 4D-flow data and correlated with lung histology. (3) Results: The pressure gradient between the pulmonary artery and vein on the unilateral side as well as the time-averaged mean velocity values of the small pulmonary arteries were capable of distinguishing not only between baseline and severe PAH, but also between the moderate and severe stages of the disease. (4) Conclusions: The current preclinical study suggests the pulmonary arteriovenous pressure gradient and the time-averaged mean velocity as potential biomarkers to diagnose PAH. |
| first_indexed | 2024-03-10T01:39:14Z |
| format | Article |
| id | doaj.art-40eb0b4ef08843bb8ade0e202d167d7b |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T01:39:14Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-40eb0b4ef08843bb8ade0e202d167d7b2023-11-23T13:27:30ZengMDPI AGDiagnostics2075-44182021-12-011215810.3390/diagnostics12010058Pulmonary Arteriovenous Pressure Gradient and Time-Averaged Mean Velocity of Small Pulmonary Arteries Can Serve as Sensitive Biomarkers in the Diagnosis of Pulmonary Arterial Hypertension: A Preclinical Study by 4D-Flow MRIAli Nahardani0Simon Leistikow1Katja Grün2Martin Krämer3Karl-Heinz Herrmann4Andrea Schrepper5Christian Jung6Sara Moradi7Paul Christian Schulze8Lars Linsen9Jürgen R. Reichenbach10Verena Hoerr11Marcus Franz12Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich Schiller University Jena, 07747 Jena, GermanyDepartment of Mathematics and Computer Science, Institute of Computer Science, Westfälische Wilhelms-Universität Münster, 48149 Munster, GermanyDepartment of Internal Medicine I, Division of Cardiology, Angiology, Pneumology, and Intensive Medical Care, Jena University Hospital, 07747 Jena, GermanyMedical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich Schiller University Jena, 07747 Jena, GermanyMedical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich Schiller University Jena, 07747 Jena, GermanyDepartment of Cardiothoracic Surgery, Jena University Hospital, 07747 Jena, GermanyDepartment of Internal Medicine, Division of Cardiology, University Hospital Düsseldorf, 40225 Dusseldorf, GermanyHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Internal Medicine I, Division of Cardiology, Angiology, Pneumology, and Intensive Medical Care, Jena University Hospital, 07747 Jena, GermanyDepartment of Mathematics and Computer Science, Institute of Computer Science, Westfälische Wilhelms-Universität Münster, 48149 Munster, GermanyMedical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich Schiller University Jena, 07747 Jena, GermanyMedical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich Schiller University Jena, 07747 Jena, GermanyDepartment of Internal Medicine I, Division of Cardiology, Angiology, Pneumology, and Intensive Medical Care, Jena University Hospital, 07747 Jena, Germany(1) Background: Pulmonary arterial hypertension (PAH) is a serious condition that is associated with many cardiopulmonary diseases. Invasive right heart catheterization (RHC) is currently the only method for the definitive diagnosis and follow-up of PAH. In this study, we sought a non-invasive hemodynamic biomarker for the diagnosis of PAH. (2) Methods: We applied prospectively respiratory and cardiac gated 4D-flow MRI at a 9.4T preclinical scanner on three different groups of Sprague Dawley rats: baseline (<i>n</i> = 11), moderate PAH (<i>n</i> = 8), and severe PAH (<i>n</i> = 8). The pressure gradients as well as the velocity values were analyzed from 4D-flow data and correlated with lung histology. (3) Results: The pressure gradient between the pulmonary artery and vein on the unilateral side as well as the time-averaged mean velocity values of the small pulmonary arteries were capable of distinguishing not only between baseline and severe PAH, but also between the moderate and severe stages of the disease. (4) Conclusions: The current preclinical study suggests the pulmonary arteriovenous pressure gradient and the time-averaged mean velocity as potential biomarkers to diagnose PAH.https://www.mdpi.com/2075-4418/12/1/58pulmonary hypertensioncardiac magnetic resonancetreatment responsehemodynamics4D-flow |
| spellingShingle | Ali Nahardani Simon Leistikow Katja Grün Martin Krämer Karl-Heinz Herrmann Andrea Schrepper Christian Jung Sara Moradi Paul Christian Schulze Lars Linsen Jürgen R. Reichenbach Verena Hoerr Marcus Franz Pulmonary Arteriovenous Pressure Gradient and Time-Averaged Mean Velocity of Small Pulmonary Arteries Can Serve as Sensitive Biomarkers in the Diagnosis of Pulmonary Arterial Hypertension: A Preclinical Study by 4D-Flow MRI Diagnostics pulmonary hypertension cardiac magnetic resonance treatment response hemodynamics 4D-flow |
| title | Pulmonary Arteriovenous Pressure Gradient and Time-Averaged Mean Velocity of Small Pulmonary Arteries Can Serve as Sensitive Biomarkers in the Diagnosis of Pulmonary Arterial Hypertension: A Preclinical Study by 4D-Flow MRI |
| title_full | Pulmonary Arteriovenous Pressure Gradient and Time-Averaged Mean Velocity of Small Pulmonary Arteries Can Serve as Sensitive Biomarkers in the Diagnosis of Pulmonary Arterial Hypertension: A Preclinical Study by 4D-Flow MRI |
| title_fullStr | Pulmonary Arteriovenous Pressure Gradient and Time-Averaged Mean Velocity of Small Pulmonary Arteries Can Serve as Sensitive Biomarkers in the Diagnosis of Pulmonary Arterial Hypertension: A Preclinical Study by 4D-Flow MRI |
| title_full_unstemmed | Pulmonary Arteriovenous Pressure Gradient and Time-Averaged Mean Velocity of Small Pulmonary Arteries Can Serve as Sensitive Biomarkers in the Diagnosis of Pulmonary Arterial Hypertension: A Preclinical Study by 4D-Flow MRI |
| title_short | Pulmonary Arteriovenous Pressure Gradient and Time-Averaged Mean Velocity of Small Pulmonary Arteries Can Serve as Sensitive Biomarkers in the Diagnosis of Pulmonary Arterial Hypertension: A Preclinical Study by 4D-Flow MRI |
| title_sort | pulmonary arteriovenous pressure gradient and time averaged mean velocity of small pulmonary arteries can serve as sensitive biomarkers in the diagnosis of pulmonary arterial hypertension a preclinical study by 4d flow mri |
| topic | pulmonary hypertension cardiac magnetic resonance treatment response hemodynamics 4D-flow |
| url | https://www.mdpi.com/2075-4418/12/1/58 |
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