Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder
Idiopathic rapid eye movement sleep behavior disorder (iRBD) is often a precursor to neurodegenerative disease. However, voxel-based morphological studies evaluating structural abnormalities in the brains of iRBD patients are relatively rare. This study aimed to explore cerebral structural alteratio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Neural Regeneration Research |
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| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=5;spage=868;epage=875;aulast=Han |
| _version_ | 1828433789295001600 |
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| author | Xian-Hua Han Xiu-Ming Li Wei-Jun Tang Huan Yu Ping Wu Jing-Jie Ge Jian Wang Chuan-Tao Zuo Kuang-Yu Shi |
| author_facet | Xian-Hua Han Xiu-Ming Li Wei-Jun Tang Huan Yu Ping Wu Jing-Jie Ge Jian Wang Chuan-Tao Zuo Kuang-Yu Shi |
| author_sort | Xian-Hua Han |
| collection | DOAJ |
| description | Idiopathic rapid eye movement sleep behavior disorder (iRBD) is often a precursor to neurodegenerative disease. However, voxel-based morphological studies evaluating structural abnormalities in the brains of iRBD patients are relatively rare. This study aimed to explore cerebral structural alterations using magnetic resonance imaging and to determine their association with clinical parameters in iRBD patients. Brain structural T1-weighted MRI scans were acquired from 19 polysomnogram-confirmed iRBD patients (male:female 16:3; mean age 66.6 ± 7.0 years) and 20 age-matched healthy controls (male:female 5:15; mean age 63.7 ± 5.9 years). Gray matter volume (GMV) data were analyzed based on Statistical Parametric Mapping 8, using a voxel-based morphometry method and two-sample t-test and multiple regression analysis. Compared with controls, iRBD patients had increased GMV in the middle temporal gyrus and cerebellar posterior lobe, but decreased GMV in the Rolandic operculum, postcentral gyrus, insular lobe, cingulate gyrus, precuneus, rectus gyrus, and superior frontal gyrus. iRBD duration was positively correlated with GMV in the precuneus, cuneus, superior parietal gyrus, postcentral gyrus, posterior cingulate gyrus, hippocampus, lingual gyrus, middle occipital gyrus, middle temporal gyrus, and cerebellum posterior lobe. Furthermore, phasic chin electromyographic activity was positively correlated with GMV in the hippocampus, precuneus, fusiform gyrus, precentral gyrus, superior frontal gyrus, cuneus, inferior parietal lobule, angular gyrus, superior parietal gyrus, paracentral lobule, and cerebellar posterior lobe. There were no significant negative correlations of brain GMV with disease duration or electromyographic activity in iRBD patients. These findings expand the spectrum of known gray matter modifications in iRBD patients and provide evidence of a correlation between brain dysfunction and clinical manifestations in such patients. The protocol was approved by the Ethics Committee of Huashan Hospital (approval No. KY2013-336) on January 6, 2014. This trial was registered in the ISRCTN registry (ISRCTN18238599). |
| first_indexed | 2024-12-10T18:40:46Z |
| format | Article |
| id | doaj.art-40ee189d94434fdfa793678c328da3e5 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-10T18:40:46Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-40ee189d94434fdfa793678c328da3e52022-12-22T01:37:39ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742019-01-0114586887510.4103/1673-5374.249235Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorderXian-Hua HanXiu-Ming LiWei-Jun TangHuan YuPing WuJing-Jie GeJian WangChuan-Tao ZuoKuang-Yu ShiIdiopathic rapid eye movement sleep behavior disorder (iRBD) is often a precursor to neurodegenerative disease. However, voxel-based morphological studies evaluating structural abnormalities in the brains of iRBD patients are relatively rare. This study aimed to explore cerebral structural alterations using magnetic resonance imaging and to determine their association with clinical parameters in iRBD patients. Brain structural T1-weighted MRI scans were acquired from 19 polysomnogram-confirmed iRBD patients (male:female 16:3; mean age 66.6 ± 7.0 years) and 20 age-matched healthy controls (male:female 5:15; mean age 63.7 ± 5.9 years). Gray matter volume (GMV) data were analyzed based on Statistical Parametric Mapping 8, using a voxel-based morphometry method and two-sample t-test and multiple regression analysis. Compared with controls, iRBD patients had increased GMV in the middle temporal gyrus and cerebellar posterior lobe, but decreased GMV in the Rolandic operculum, postcentral gyrus, insular lobe, cingulate gyrus, precuneus, rectus gyrus, and superior frontal gyrus. iRBD duration was positively correlated with GMV in the precuneus, cuneus, superior parietal gyrus, postcentral gyrus, posterior cingulate gyrus, hippocampus, lingual gyrus, middle occipital gyrus, middle temporal gyrus, and cerebellum posterior lobe. Furthermore, phasic chin electromyographic activity was positively correlated with GMV in the hippocampus, precuneus, fusiform gyrus, precentral gyrus, superior frontal gyrus, cuneus, inferior parietal lobule, angular gyrus, superior parietal gyrus, paracentral lobule, and cerebellar posterior lobe. There were no significant negative correlations of brain GMV with disease duration or electromyographic activity in iRBD patients. These findings expand the spectrum of known gray matter modifications in iRBD patients and provide evidence of a correlation between brain dysfunction and clinical manifestations in such patients. The protocol was approved by the Ethics Committee of Huashan Hospital (approval No. KY2013-336) on January 6, 2014. This trial was registered in the ISRCTN registry (ISRCTN18238599).http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=5;spage=868;epage=875;aulast=Hannerve regeneration; idiopathic rapid eye movement sleep behavior disorder; synucleinopathies; magnetic resonance imaging; gray matter volume; statistic parametric mapping; voxel-based morphometry; structure; Parkinson′s disease; neurodegenerative diseases; neural regeneration |
| spellingShingle | Xian-Hua Han Xiu-Ming Li Wei-Jun Tang Huan Yu Ping Wu Jing-Jie Ge Jian Wang Chuan-Tao Zuo Kuang-Yu Shi Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder Neural Regeneration Research nerve regeneration; idiopathic rapid eye movement sleep behavior disorder; synucleinopathies; magnetic resonance imaging; gray matter volume; statistic parametric mapping; voxel-based morphometry; structure; Parkinson′s disease; neurodegenerative diseases; neural regeneration |
| title | Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder |
| title_full | Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder |
| title_fullStr | Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder |
| title_full_unstemmed | Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder |
| title_short | Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder |
| title_sort | assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder |
| topic | nerve regeneration; idiopathic rapid eye movement sleep behavior disorder; synucleinopathies; magnetic resonance imaging; gray matter volume; statistic parametric mapping; voxel-based morphometry; structure; Parkinson′s disease; neurodegenerative diseases; neural regeneration |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=5;spage=868;epage=875;aulast=Han |
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