Translational Control of the HIV Unspliced Genomic RNA

Post-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicin...

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Main Authors: Bárbara Rojas-Araya, Théophile Ohlmann, Ricardo Soto-Rifo
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Viruses
Subjects:
Online Access:http://www.mdpi.com/1999-4915/7/8/2822
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author Bárbara Rojas-Araya
Théophile Ohlmann
Ricardo Soto-Rifo
author_facet Bárbara Rojas-Araya
Théophile Ohlmann
Ricardo Soto-Rifo
author_sort Bárbara Rojas-Araya
collection DOAJ
description Post-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicing, export, and translation. It appears increasingly obvious that all these steps are interconnected and they result in the building of a viral ribonucleoprotein complex (RNP) that must be efficiently translated in the cytosolic compartment. This review summarizes our knowledge about the genesis, localization, and expression of this viral RNP.
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spelling doaj.art-40ef3e4daf6341dba458e847e8b779c62022-12-22T01:15:24ZengMDPI AGViruses1999-49152015-08-01784326435110.3390/v7082822v7082822Translational Control of the HIV Unspliced Genomic RNABárbara Rojas-Araya0Théophile Ohlmann1Ricardo Soto-Rifo2Molecular and Cellular Virology Laboratory, Program of Virology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 834100, Santiago, ChileCIRI, International Center for Infectiology Research, Université de Lyon, Lyon 69007, FranceMolecular and Cellular Virology Laboratory, Program of Virology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 834100, Santiago, ChilePost-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicing, export, and translation. It appears increasingly obvious that all these steps are interconnected and they result in the building of a viral ribonucleoprotein complex (RNP) that must be efficiently translated in the cytosolic compartment. This review summarizes our knowledge about the genesis, localization, and expression of this viral RNP.http://www.mdpi.com/1999-4915/7/8/2822HIV-1Revnuclear exportDDX3cap-dependent translationIRES
spellingShingle Bárbara Rojas-Araya
Théophile Ohlmann
Ricardo Soto-Rifo
Translational Control of the HIV Unspliced Genomic RNA
Viruses
HIV-1
Rev
nuclear export
DDX3
cap-dependent translation
IRES
title Translational Control of the HIV Unspliced Genomic RNA
title_full Translational Control of the HIV Unspliced Genomic RNA
title_fullStr Translational Control of the HIV Unspliced Genomic RNA
title_full_unstemmed Translational Control of the HIV Unspliced Genomic RNA
title_short Translational Control of the HIV Unspliced Genomic RNA
title_sort translational control of the hiv unspliced genomic rna
topic HIV-1
Rev
nuclear export
DDX3
cap-dependent translation
IRES
url http://www.mdpi.com/1999-4915/7/8/2822
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