Translational Control of the HIV Unspliced Genomic RNA
Post-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicin...
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Format: | Article |
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MDPI AG
2015-08-01
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Series: | Viruses |
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Online Access: | http://www.mdpi.com/1999-4915/7/8/2822 |
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author | Bárbara Rojas-Araya Théophile Ohlmann Ricardo Soto-Rifo |
author_facet | Bárbara Rojas-Araya Théophile Ohlmann Ricardo Soto-Rifo |
author_sort | Bárbara Rojas-Araya |
collection | DOAJ |
description | Post-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicing, export, and translation. It appears increasingly obvious that all these steps are interconnected and they result in the building of a viral ribonucleoprotein complex (RNP) that must be efficiently translated in the cytosolic compartment. This review summarizes our knowledge about the genesis, localization, and expression of this viral RNP. |
first_indexed | 2024-12-11T07:48:06Z |
format | Article |
id | doaj.art-40ef3e4daf6341dba458e847e8b779c6 |
institution | Directory Open Access Journal |
issn | 1999-4915 |
language | English |
last_indexed | 2024-12-11T07:48:06Z |
publishDate | 2015-08-01 |
publisher | MDPI AG |
record_format | Article |
series | Viruses |
spelling | doaj.art-40ef3e4daf6341dba458e847e8b779c62022-12-22T01:15:24ZengMDPI AGViruses1999-49152015-08-01784326435110.3390/v7082822v7082822Translational Control of the HIV Unspliced Genomic RNABárbara Rojas-Araya0Théophile Ohlmann1Ricardo Soto-Rifo2Molecular and Cellular Virology Laboratory, Program of Virology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 834100, Santiago, ChileCIRI, International Center for Infectiology Research, Université de Lyon, Lyon 69007, FranceMolecular and Cellular Virology Laboratory, Program of Virology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 834100, Santiago, ChilePost-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicing, export, and translation. It appears increasingly obvious that all these steps are interconnected and they result in the building of a viral ribonucleoprotein complex (RNP) that must be efficiently translated in the cytosolic compartment. This review summarizes our knowledge about the genesis, localization, and expression of this viral RNP.http://www.mdpi.com/1999-4915/7/8/2822HIV-1Revnuclear exportDDX3cap-dependent translationIRES |
spellingShingle | Bárbara Rojas-Araya Théophile Ohlmann Ricardo Soto-Rifo Translational Control of the HIV Unspliced Genomic RNA Viruses HIV-1 Rev nuclear export DDX3 cap-dependent translation IRES |
title | Translational Control of the HIV Unspliced Genomic RNA |
title_full | Translational Control of the HIV Unspliced Genomic RNA |
title_fullStr | Translational Control of the HIV Unspliced Genomic RNA |
title_full_unstemmed | Translational Control of the HIV Unspliced Genomic RNA |
title_short | Translational Control of the HIV Unspliced Genomic RNA |
title_sort | translational control of the hiv unspliced genomic rna |
topic | HIV-1 Rev nuclear export DDX3 cap-dependent translation IRES |
url | http://www.mdpi.com/1999-4915/7/8/2822 |
work_keys_str_mv | AT barbararojasaraya translationalcontrolofthehivunsplicedgenomicrna AT theophileohlmann translationalcontrolofthehivunsplicedgenomicrna AT ricardosotorifo translationalcontrolofthehivunsplicedgenomicrna |