Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs)
Microbial infections are still among the major public health concerns since several yeasts and fungi, and other pathogenic microorganisms, are responsible for continuous growth of infections and drug resistance against bacteria. Antimicrobial resistance rate is fostering the need to develop new stra...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/10/3/560 |
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| author | Maria C. Teixeira Claudia Carbone Maria C. Sousa Marta Espina Maria L. Garcia Elena Sanchez-Lopez Eliana B. Souto |
| author_facet | Maria C. Teixeira Claudia Carbone Maria C. Sousa Marta Espina Maria L. Garcia Elena Sanchez-Lopez Eliana B. Souto |
| author_sort | Maria C. Teixeira |
| collection | DOAJ |
| description | Microbial infections are still among the major public health concerns since several yeasts and fungi, and other pathogenic microorganisms, are responsible for continuous growth of infections and drug resistance against bacteria. Antimicrobial resistance rate is fostering the need to develop new strategies against drug-resistant superbugs. Antimicrobial peptides (AMPs) are small peptide-based molecules of 5−100 amino acids in length, with potent and broad-spectrum antimicrobial properties. They are part of the innate immune system, which can represent a minimal risk of resistance development. These characteristics contribute to the description of these molecules as promising new molecules in the development of new antimicrobial drugs. However, efforts in developing new medicines have not resulted in any decrease of drug resistance yet. Thus, a technological approach on improving existing drugs is gaining special interest. Nanomedicine provides easy access to innovative carriers, which ultimately enable the design and development of targeted delivery systems of the most efficient drugs with increased efficacy and reduced toxicity. Based on performance, successful experiments, and considerable market prospects, nanotechnology will undoubtedly lead a breakthrough in biomedical field also for infectious diseases, as there are several nanotechnological approaches that exhibit important roles in restoring antibiotic activity against resistant bacteria. |
| first_indexed | 2024-12-20T06:13:47Z |
| format | Article |
| id | doaj.art-40ef49fb609544a191e1624790d99b4b |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-20T06:13:47Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-40ef49fb609544a191e1624790d99b4b2022-12-21T19:50:36ZengMDPI AGNanomaterials2079-49912020-03-0110356010.3390/nano10030560nano10030560Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs)Maria C. Teixeira0Claudia Carbone1Maria C. Sousa2Marta Espina3Maria L. Garcia4Elena Sanchez-Lopez5Eliana B. Souto6Laboratory of Pharmaceutical Development and Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalLaboratory of Pharmaceutical Development and Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalLaboratory of Microbiology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, SpainDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, SpainDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, SpainLaboratory of Pharmaceutical Development and Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalMicrobial infections are still among the major public health concerns since several yeasts and fungi, and other pathogenic microorganisms, are responsible for continuous growth of infections and drug resistance against bacteria. Antimicrobial resistance rate is fostering the need to develop new strategies against drug-resistant superbugs. Antimicrobial peptides (AMPs) are small peptide-based molecules of 5−100 amino acids in length, with potent and broad-spectrum antimicrobial properties. They are part of the innate immune system, which can represent a minimal risk of resistance development. These characteristics contribute to the description of these molecules as promising new molecules in the development of new antimicrobial drugs. However, efforts in developing new medicines have not resulted in any decrease of drug resistance yet. Thus, a technological approach on improving existing drugs is gaining special interest. Nanomedicine provides easy access to innovative carriers, which ultimately enable the design and development of targeted delivery systems of the most efficient drugs with increased efficacy and reduced toxicity. Based on performance, successful experiments, and considerable market prospects, nanotechnology will undoubtedly lead a breakthrough in biomedical field also for infectious diseases, as there are several nanotechnological approaches that exhibit important roles in restoring antibiotic activity against resistant bacteria.https://www.mdpi.com/2079-4991/10/3/560antimicrobial peptidesbacterial and virus infectionscoronavirusantimicrobial resistancenanomaterialsnanomedicine |
| spellingShingle | Maria C. Teixeira Claudia Carbone Maria C. Sousa Marta Espina Maria L. Garcia Elena Sanchez-Lopez Eliana B. Souto Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs) Nanomaterials antimicrobial peptides bacterial and virus infections coronavirus antimicrobial resistance nanomaterials nanomedicine |
| title | Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs) |
| title_full | Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs) |
| title_fullStr | Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs) |
| title_full_unstemmed | Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs) |
| title_short | Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs) |
| title_sort | nanomedicines for the delivery of antimicrobial peptides amps |
| topic | antimicrobial peptides bacterial and virus infections coronavirus antimicrobial resistance nanomaterials nanomedicine |
| url | https://www.mdpi.com/2079-4991/10/3/560 |
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