Comparison of the effects of two different formulas of fluids in craniotomy patients
Background: Intraoperative fluid management of the patients who had undergone neurosurgery presents special challenges for the anesthesiologist. In this study, we aimed to compare the effects of two fluid combinations (half-normal + bicarbonate with saline + Ringer′s lactate) on brain relaxation, an...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Advanced Biomedical Research |
| Subjects: | |
| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=257;epage=257;aulast=Attari |
| _version_ | 1811336876660883456 |
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| author | Mohammadali Attari Shahryar Sane Akbar Bordbar |
| author_facet | Mohammadali Attari Shahryar Sane Akbar Bordbar |
| author_sort | Mohammadali Attari |
| collection | DOAJ |
| description | Background: Intraoperative fluid management of the patients who had undergone neurosurgery presents special challenges for the anesthesiologist. In this study, we aimed to compare the effects of two fluid combinations (half-normal + bicarbonate with saline + Ringer′s lactate) on brain relaxation, and acid, base, and hemodynamic balance in patients undergoing elective craniotomy surgery.
Materials and Methods: This randomized double-blind controlled clinical trial study was done on 50 patients, of age 20-60 years, undergoing craniotomy in Alzahra Hospital in 2012. They were divided in two groups of 25 patients each. In the control group, after the patients received hypertonic saline, normal saline serum and Ringer′s lactate was administered, and in the half-normal study group, 80 ml of sodium bicarbonate for every liter of it was added. Arterial blood gas (ABG) was taken before the last suture. Brain relaxation before dura opening was registered.
Results: There was no significant difference in heart rate changes (P = 0.054). No significant difference was observed in the mean arterial pressure between the two groups (P = 0.99). Changes in pH, HCO3, and BE were not significantly different (P = 0.99) between the two groups. Urine output in half-normal saline group was significantly higher than in normal saline group. The mean bleeding volume was higher in normal saline group, but was not significantly different (P = 0.54). The mean volume of injected blood was higher in half-normal group with a significant difference (P = 0.54). The injected blood volume mean in half-normal group was higher with no significant difference (P = 0.55). The mean of brain relaxation was not different (P = 0.5).
Conclusion: These two fluids did not show any significant differences in the studied variables in this research. |
| first_indexed | 2024-04-13T17:45:57Z |
| format | Article |
| id | doaj.art-40f118626d8b4bb5b9063d38aac49f5c |
| institution | Directory Open Access Journal |
| issn | 2277-9175 2277-9175 |
| language | English |
| last_indexed | 2024-04-13T17:45:57Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj.art-40f118626d8b4bb5b9063d38aac49f5c2022-12-22T02:36:58ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752277-91752014-01-013125725710.4103/2277-9175.146927Comparison of the effects of two different formulas of fluids in craniotomy patientsMohammadali AttariShahryar SaneAkbar BordbarBackground: Intraoperative fluid management of the patients who had undergone neurosurgery presents special challenges for the anesthesiologist. In this study, we aimed to compare the effects of two fluid combinations (half-normal + bicarbonate with saline + Ringer′s lactate) on brain relaxation, and acid, base, and hemodynamic balance in patients undergoing elective craniotomy surgery. Materials and Methods: This randomized double-blind controlled clinical trial study was done on 50 patients, of age 20-60 years, undergoing craniotomy in Alzahra Hospital in 2012. They were divided in two groups of 25 patients each. In the control group, after the patients received hypertonic saline, normal saline serum and Ringer′s lactate was administered, and in the half-normal study group, 80 ml of sodium bicarbonate for every liter of it was added. Arterial blood gas (ABG) was taken before the last suture. Brain relaxation before dura opening was registered. Results: There was no significant difference in heart rate changes (P = 0.054). No significant difference was observed in the mean arterial pressure between the two groups (P = 0.99). Changes in pH, HCO3, and BE were not significantly different (P = 0.99) between the two groups. Urine output in half-normal saline group was significantly higher than in normal saline group. The mean bleeding volume was higher in normal saline group, but was not significantly different (P = 0.54). The mean volume of injected blood was higher in half-normal group with a significant difference (P = 0.54). The injected blood volume mean in half-normal group was higher with no significant difference (P = 0.55). The mean of brain relaxation was not different (P = 0.5). Conclusion: These two fluids did not show any significant differences in the studied variables in this research.http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=257;epage=257;aulast=AttariAcid-base hemodynamic parametersbrain relaxationcraniotomyhalf-normal and bicarbonate with salineRinger′s lactate |
| spellingShingle | Mohammadali Attari Shahryar Sane Akbar Bordbar Comparison of the effects of two different formulas of fluids in craniotomy patients Advanced Biomedical Research Acid-base hemodynamic parameters brain relaxation craniotomy half-normal and bicarbonate with saline Ringer′s lactate |
| title | Comparison of the effects of two different formulas of fluids in craniotomy patients |
| title_full | Comparison of the effects of two different formulas of fluids in craniotomy patients |
| title_fullStr | Comparison of the effects of two different formulas of fluids in craniotomy patients |
| title_full_unstemmed | Comparison of the effects of two different formulas of fluids in craniotomy patients |
| title_short | Comparison of the effects of two different formulas of fluids in craniotomy patients |
| title_sort | comparison of the effects of two different formulas of fluids in craniotomy patients |
| topic | Acid-base hemodynamic parameters brain relaxation craniotomy half-normal and bicarbonate with saline Ringer′s lactate |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=257;epage=257;aulast=Attari |
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