The Long-Term Impact of Rotavirus Vaccines in Korea, 2008–2020; Emergence of G8P[8] Strain
This study evaluated the long-term impact of rotavirus vaccination on prevalence, seasonality, and genotype distribution in Gwangju, Korea for 13 seasons. Rotavirus was identified using ELISA and then sequenced for G and P genotypes by Reverse Transcription Polymerase Chain Reactions for diarrhoeage...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/4/406 |
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| author | Kwang gon Kim Hye-young Kee Hye jung Park Jae Keun Chung Tae sun Kim Min Ji Kim |
| author_facet | Kwang gon Kim Hye-young Kee Hye jung Park Jae Keun Chung Tae sun Kim Min Ji Kim |
| author_sort | Kwang gon Kim |
| collection | DOAJ |
| description | This study evaluated the long-term impact of rotavirus vaccination on prevalence, seasonality, and genotype distribution in Gwangju, Korea for 13 seasons. Rotavirus was identified using ELISA and then sequenced for G and P genotypes by Reverse Transcription Polymerase Chain Reactions for diarrhoeagenic patient specimens from local hospitals between January 2008 and August2020. Of 26,902 fecal samples, 2919 samples (10.9%) were ELISA positive. The prevalence declined from 16.3% in pre-vaccine era to 5.4% in post-vaccine era. In the pre-vaccine period, G1P[8] was the most common genotype, followed by G2P[4], G3P[8], and G9P[8], etc. In the transitional period, the proportion of G2P[4] became the dominant genotype and G1P[8] was still commonly identified. In contrast, the novel genotype G8P[8] was predominant in the post-vaccine period. Meanwhile, G2P[4] and G8P[8] were major genotypes in both Rotarix and RotaTeq groups. The substantial decline of G1P[8] prevalence, reemergence of G1P[8], G3P[8], and G2P[4] rotavirus strains, and surge of the rare G8P[8] after vaccine introduction were interesting points to note. The continuous surveillance on the genotypes of RV will be needed to understand rotavirus epidemiology and their evolutionary patterns, as caution is required when interpreting temporal changes in RV genotype dynamic. |
| first_indexed | 2024-03-10T12:09:29Z |
| format | Article |
| id | doaj.art-40f1da0a71d34c4ab74be98f4dd11c18 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T12:09:29Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-40f1da0a71d34c4ab74be98f4dd11c182023-11-21T16:16:58ZengMDPI AGVaccines2076-393X2021-04-019440610.3390/vaccines9040406The Long-Term Impact of Rotavirus Vaccines in Korea, 2008–2020; Emergence of G8P[8] StrainKwang gon Kim0Hye-young Kee1Hye jung Park2Jae Keun Chung3Tae sun Kim4Min Ji Kim5Health and Environment Research Institute of Gwangju, Gwangju 61954, KoreaHealth and Environment Research Institute of Gwangju, Gwangju 61954, KoreaHealth and Environment Research Institute of Gwangju, Gwangju 61954, KoreaHealth and Environment Research Institute of Gwangju, Gwangju 61954, KoreaHealth and Environment Research Institute of Gwangju, Gwangju 61954, KoreaHealth and Environment Research Institute of Gwangju, Gwangju 61954, KoreaThis study evaluated the long-term impact of rotavirus vaccination on prevalence, seasonality, and genotype distribution in Gwangju, Korea for 13 seasons. Rotavirus was identified using ELISA and then sequenced for G and P genotypes by Reverse Transcription Polymerase Chain Reactions for diarrhoeagenic patient specimens from local hospitals between January 2008 and August2020. Of 26,902 fecal samples, 2919 samples (10.9%) were ELISA positive. The prevalence declined from 16.3% in pre-vaccine era to 5.4% in post-vaccine era. In the pre-vaccine period, G1P[8] was the most common genotype, followed by G2P[4], G3P[8], and G9P[8], etc. In the transitional period, the proportion of G2P[4] became the dominant genotype and G1P[8] was still commonly identified. In contrast, the novel genotype G8P[8] was predominant in the post-vaccine period. Meanwhile, G2P[4] and G8P[8] were major genotypes in both Rotarix and RotaTeq groups. The substantial decline of G1P[8] prevalence, reemergence of G1P[8], G3P[8], and G2P[4] rotavirus strains, and surge of the rare G8P[8] after vaccine introduction were interesting points to note. The continuous surveillance on the genotypes of RV will be needed to understand rotavirus epidemiology and their evolutionary patterns, as caution is required when interpreting temporal changes in RV genotype dynamic.https://www.mdpi.com/2076-393X/9/4/406rotavirusgenotypeRotarixRotaTeqG8P[8] |
| spellingShingle | Kwang gon Kim Hye-young Kee Hye jung Park Jae Keun Chung Tae sun Kim Min Ji Kim The Long-Term Impact of Rotavirus Vaccines in Korea, 2008–2020; Emergence of G8P[8] Strain Vaccines rotavirus genotype Rotarix RotaTeq G8P[8] |
| title | The Long-Term Impact of Rotavirus Vaccines in Korea, 2008–2020; Emergence of G8P[8] Strain |
| title_full | The Long-Term Impact of Rotavirus Vaccines in Korea, 2008–2020; Emergence of G8P[8] Strain |
| title_fullStr | The Long-Term Impact of Rotavirus Vaccines in Korea, 2008–2020; Emergence of G8P[8] Strain |
| title_full_unstemmed | The Long-Term Impact of Rotavirus Vaccines in Korea, 2008–2020; Emergence of G8P[8] Strain |
| title_short | The Long-Term Impact of Rotavirus Vaccines in Korea, 2008–2020; Emergence of G8P[8] Strain |
| title_sort | long term impact of rotavirus vaccines in korea 2008 2020 emergence of g8p 8 strain |
| topic | rotavirus genotype Rotarix RotaTeq G8P[8] |
| url | https://www.mdpi.com/2076-393X/9/4/406 |
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