Important Lessons on Long-Term Stability of Amino Acids in Stored Dried Blood Spots

Important Lessons on Long-Term Stability of Amino Acids in Stored Dried Blood Spots

Residual heel prick Dried Blood Spots (DBS) are valuable samples for retrospective investigation of inborn metabolic diseases (IMD) and biomarker analyses. Because many metabolites suffer time-dependent decay, we investigated the five-year stability of amino acids (AA) in residual heel prick DBS. In...

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Bibliographic Details
Main Authors: Allysa M. Dijkstra, Pim de Blaauw, Willemijn J. van Rijt, Hanneke Renting, Ronald G. H. J. Maatman, Francjan J. van Spronsen, Rose E. Maase, Peter C. J. I. Schielen, Terry G. J. Derks, M. Rebecca Heiner-Fokkema
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Neonatal Screening
Subjects:
amino acids
dried blood spots
inborn metabolic diseases
metabolite stability
neonatal blood spot screening
tandem mass spectrometry
Online Access:https://www.mdpi.com/2409-515X/9/3/34

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https://www.mdpi.com/2409-515X/9/3/34

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