Near-infrared light-heatable platinum nanozyme for synergistic bacterial inhibition
The development of non-antibiotic strategies for bacterial disinfection is of great clinical importance. Among recently developed different antimicrobial strategies, nanomaterial-mediated approaches, especially the photothermal way and reactive oxygen species (ROS)-generating method, show many signi...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1355004/full |
| _version_ | 1797354417070014464 |
|---|---|
| author | Xue Li Xue Li Weisheng Zhu Yuan Zhou Yuan Zhou Nan Wang Xiangfan Gao Suling Sun Mengting Cao Zhijun Zhang Zhijun Zhang Guixian Hu |
| author_facet | Xue Li Xue Li Weisheng Zhu Yuan Zhou Yuan Zhou Nan Wang Xiangfan Gao Suling Sun Mengting Cao Zhijun Zhang Zhijun Zhang Guixian Hu |
| author_sort | Xue Li |
| collection | DOAJ |
| description | The development of non-antibiotic strategies for bacterial disinfection is of great clinical importance. Among recently developed different antimicrobial strategies, nanomaterial-mediated approaches, especially the photothermal way and reactive oxygen species (ROS)-generating method, show many significant advantages. Although promising, the clinical application of nanomaterials is still limited, owing to the potential biosafety issues. Further improvement of the antimicrobial activity to reduce the usage, and thus reduce the potential risk, is an important way to increase the clinical applicability of antibacterial nanomaterials. In this paper, an antimicrobial nanostructure with both an excellent photothermal effect and peroxidase-like activity was constructed to achieve efficient synergistic antimicrobial activity. The obtained nano-antimicrobial agent (ZIF-8@PDA@Pt) can not only efficiently catalyze the production of ROS from H2O2 to cause damage to bacteria but also convert the photon energy of near-infrared light into thermal energy to kill bacteria, and the two synergistic effects induced in a highly efficient antimicrobial activity. This study not only offers a new nanomaterial with efficient antibacterial activity but also proposes a new idea for constructing synergistic antibacterial properties. |
| first_indexed | 2024-03-08T13:50:08Z |
| format | Article |
| id | doaj.art-40f4991f2aeb4b68b52c3c77be9b1032 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-08T13:50:08Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-40f4991f2aeb4b68b52c3c77be9b10322024-01-16T04:29:05ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-01-011210.3389/fbioe.2024.13550041355004Near-infrared light-heatable platinum nanozyme for synergistic bacterial inhibitionXue Li0Xue Li1Weisheng Zhu2Yuan Zhou3Yuan Zhou4Nan Wang5Xiangfan Gao6Suling Sun7Mengting Cao8Zhijun Zhang9Zhijun Zhang10Guixian Hu11Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou, ChinaKey Laboratory of Information Traceability for Agricultural Products, Ministry of Agriculture and Rural Affairs of China, Hangzhou, Zhejiang, ChinaKey Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou, ChinaDepartment of Pharmacy, Taihe Hospital, Hubei University of Medicine, Shiyan, ChinaCollege of Pharmacy, Hubei University of Traditional Chinese Medicine, Wuhan, ChinaKey Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou, ChinaKey Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou, ChinaInstitute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou, ChinaKey Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou, ChinaKey Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou, ChinaShengzhou Innovation Research Institute of Zhejiang Sci-Tech University, Shengzhou, ChinaInstitute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou, ChinaThe development of non-antibiotic strategies for bacterial disinfection is of great clinical importance. Among recently developed different antimicrobial strategies, nanomaterial-mediated approaches, especially the photothermal way and reactive oxygen species (ROS)-generating method, show many significant advantages. Although promising, the clinical application of nanomaterials is still limited, owing to the potential biosafety issues. Further improvement of the antimicrobial activity to reduce the usage, and thus reduce the potential risk, is an important way to increase the clinical applicability of antibacterial nanomaterials. In this paper, an antimicrobial nanostructure with both an excellent photothermal effect and peroxidase-like activity was constructed to achieve efficient synergistic antimicrobial activity. The obtained nano-antimicrobial agent (ZIF-8@PDA@Pt) can not only efficiently catalyze the production of ROS from H2O2 to cause damage to bacteria but also convert the photon energy of near-infrared light into thermal energy to kill bacteria, and the two synergistic effects induced in a highly efficient antimicrobial activity. This study not only offers a new nanomaterial with efficient antibacterial activity but also proposes a new idea for constructing synergistic antibacterial properties.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1355004/fullnanozymemetal–organic frameworkphotothermal effectreactive oxygen speciesbacterial inhibition |
| spellingShingle | Xue Li Xue Li Weisheng Zhu Yuan Zhou Yuan Zhou Nan Wang Xiangfan Gao Suling Sun Mengting Cao Zhijun Zhang Zhijun Zhang Guixian Hu Near-infrared light-heatable platinum nanozyme for synergistic bacterial inhibition Frontiers in Bioengineering and Biotechnology nanozyme metal–organic framework photothermal effect reactive oxygen species bacterial inhibition |
| title | Near-infrared light-heatable platinum nanozyme for synergistic bacterial inhibition |
| title_full | Near-infrared light-heatable platinum nanozyme for synergistic bacterial inhibition |
| title_fullStr | Near-infrared light-heatable platinum nanozyme for synergistic bacterial inhibition |
| title_full_unstemmed | Near-infrared light-heatable platinum nanozyme for synergistic bacterial inhibition |
| title_short | Near-infrared light-heatable platinum nanozyme for synergistic bacterial inhibition |
| title_sort | near infrared light heatable platinum nanozyme for synergistic bacterial inhibition |
| topic | nanozyme metal–organic framework photothermal effect reactive oxygen species bacterial inhibition |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1355004/full |
| work_keys_str_mv | AT xueli nearinfraredlightheatableplatinumnanozymeforsynergisticbacterialinhibition AT xueli nearinfraredlightheatableplatinumnanozymeforsynergisticbacterialinhibition AT weishengzhu nearinfraredlightheatableplatinumnanozymeforsynergisticbacterialinhibition AT yuanzhou nearinfraredlightheatableplatinumnanozymeforsynergisticbacterialinhibition AT yuanzhou nearinfraredlightheatableplatinumnanozymeforsynergisticbacterialinhibition AT nanwang nearinfraredlightheatableplatinumnanozymeforsynergisticbacterialinhibition AT xiangfangao nearinfraredlightheatableplatinumnanozymeforsynergisticbacterialinhibition AT sulingsun nearinfraredlightheatableplatinumnanozymeforsynergisticbacterialinhibition AT mengtingcao nearinfraredlightheatableplatinumnanozymeforsynergisticbacterialinhibition AT zhijunzhang nearinfraredlightheatableplatinumnanozymeforsynergisticbacterialinhibition AT zhijunzhang nearinfraredlightheatableplatinumnanozymeforsynergisticbacterialinhibition AT guixianhu nearinfraredlightheatableplatinumnanozymeforsynergisticbacterialinhibition |