Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling

Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling

Toddler/Apela/Elabela is a conserved secreted peptide that regulates mesendoderm development during zebrafish gastrulation. Two non-exclusive models have been proposed to explain Toddler function. The ‘specification model’ postulates that Toddler signaling enhances Nodal signaling to properly specif...

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Bibliographic Details
Main Authors: Megan L Norris, Andrea Pauli, James A Gagnon, Nathan D Lord, Katherine W Rogers, Christian Mosimann, Leonard I Zon, Alexander F Schier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-11-01
Series:eLife
Subjects:
Toddler
Apela
Elabela
Cxcr4a
Nodal
Gastrulation
Online Access:https://elifesciences.org/articles/22626

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